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Article

Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade

  • Authors:
    • Hiroyuki Momozono
    • Hideaki Miyake
    • Hiromoto Tei
    • Ken‑Ichi Harada
    • Masato Fujisawa
  • View Affiliations / Copyright

    Affiliations: Division of Urology, Kobe University Graduate School of Medicine, Kobe 650‑0017, Japan
  • Pages: 839-844
    |
    Published online on: March 10, 2016
       https://doi.org/10.3892/mco.2016.817
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Abstract

The present study aimed to investigate the significance of anti-androgen withdrawal and/or subsequent alternative anti-androgen therapy in patients with advanced prostate cancer (PC) who relapsed after initial maximum androgen blockade (MAB). The present study evaluated the clinical outcomes of 272 consecutive advanced PC patients undergoing anti-androgen withdrawal and/or subsequent alternative anti‑androgen therapy with flutamide following the failure of initial MAB using bicalutamide. With the exception of 41 patients (15.1%) who did not undergo anti‑androgen withdrawal due to the characteristics of PC suggesting aggressive diseases, prostate‑specific antigen (PSA) declined from the baseline value in 83 patients (35.9%), including 18 (7.8%) with PSA decline >50%, but not in the remaining 148 (64.1%). No significant difference in the overall survival (OS) or cancer‑specific survival (CSS) among the three groups was observed based on the response to anti‑androgen withdrawal. Following the introduction of alternative anti‑androgen therapy with flutamide, PSA decline was observed in 185 patients (68.0%), including 103 (37.9%) who achieved a PSA reduction of >50%; however, the PSA level continued to elevate in the remaining 87 (32.0%). Furthermore, of the numerous factors examined, only the duration of the initial MAB therapy was shown to be significantly correlated with the PSA decline following alternative anti‑androgen therapy. Multivariate analysis of several factors identified revealed that only PSA decline following alternative anti‑androgen therapy was an independent predictor of CSS and OS. If initial MAB is effective, the introduction of alternative anti‑androgen therapy may be considered; however, anti‑androgen withdrawal should be omitted, irrespective of the characteristics of advanced PC.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Wu JN, Fish KM, Evans CP, White Devere RW and Dall'Era MA: No improvement noted in overall or cause-specific survival for men presenting with metastatic prostate cancer over a 20-year period. Cancer. 120:818–823. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Harris WP, Mostaghel EA, Nelson PS and Montgomery B: Androgen deprivation therapy: Progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol. 6:76–85. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN, Oudard S, Théodore C, James ND, Turesson I, et al: Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med. 351:1502–1512. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Petrylak DP, Tangen CM, Hussain MH, Lara PN Jr, Jones JA, Taplin ME, Burch PA, Berry D, Moinpour C, Kohli M, et al: Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med. 351:1513–1520. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Sharifi N, Dahut WL and Figg WD: Secondary hormonal therapy for prostate cancer: What lies on the horizon? BJU Int. 101:271–274. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Miyamoto H, Messing EM and Chang C: Androgen deprivation therapy for prostate cancer: Current status and future prospects. Prostate. 61:332–353. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Suzuki H, Okihara K, Miyake H, Fujisawa M, Miyoshi S, Matsumoto T, Fujii M, Takihana Y, Usui T, Matsuda T, et al: Alternative nonsteroidal antiandrogen therapy for advanced prostate cancer that relapsed after initial maximum androgen blockade. J Urol. 180:921–927. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Sartor AO, Tangen CM, Hussain MH, Eisenberger MA, Parab M, Fontana JA, Chapman RA, Mills GM, Raghavan D and Crawford ED: Southwest Oncology Group: Antiandrogen withdrawal in castrate-refractory prostate cancer: A Southwest Oncology Group trial (SWOG 9426). Cancer. 112:2393–2400. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Miyake H, Hara I and Eto H: Clinical outcome of maximum androgen blockade using flutamide as second-line hormonal therapy for hormone-refractory prostate cancer. BJU Int. 96:791–795. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Kojima S, Suzuki H, Akakura K, Shimbo M, Ichikawa T and Ito H: Alternative antiandrogens to treat prostate cancer relapse after initial hormone therapy. J Urol. 171:679–683. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Okihara K, Ukimura O, Kanemitsu N, Mizutani Y, Kawauchi A and Miki T: Kyoto Prefectural University of Medicine Prostate Cancer Research Group: Clinical efficacy of alternative antiandrogen therapy in Japanese men with relapsed prostate cancer after first-line hormonal therapy. Int J Urol. 14:128–132. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Okegawa T, Nutahara K and Higashihara E: Alternative antiandrogen therapy in patients with castration-resistant prostate cancer: A single-center experience. Int J Urol. 17:950–955. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Kassouf W, Tanguay S and Aprikian AG: Nilutamide as second line hormone therapy for prostate cancer after androgen ablation fails. J Urol. 169:1742–1744. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Beltran H, Beer TM, Carducci MA, de Bono J, Gleave M, Hussain M, Kelly WK, Saad F, Sternberg C, Tagawa ST and Tannock IF: New therapies for castration-resistant prostate cancer: Efficacy and safety. Eur Urol. 60:279–290. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Suzman DL and Antonarakis ES: Castration-resistant prostate cancer: Latest evidence and therapeutic implications. Ther Adv Med Oncol. 6:167–179. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Momozono H, Miyake H, Tei H, Harada KI and Fujisawa M: Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade. Mol Clin Oncol 4: 839-844, 2016.
APA
Momozono, H., Miyake, H., Tei, H., Harada, K., & Fujisawa, M. (2016). Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade. Molecular and Clinical Oncology, 4, 839-844. https://doi.org/10.3892/mco.2016.817
MLA
Momozono, H., Miyake, H., Tei, H., Harada, K., Fujisawa, M."Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade". Molecular and Clinical Oncology 4.5 (2016): 839-844.
Chicago
Momozono, H., Miyake, H., Tei, H., Harada, K., Fujisawa, M."Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade". Molecular and Clinical Oncology 4, no. 5 (2016): 839-844. https://doi.org/10.3892/mco.2016.817
Copy and paste a formatted citation
x
Spandidos Publications style
Momozono H, Miyake H, Tei H, Harada KI and Fujisawa M: Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade. Mol Clin Oncol 4: 839-844, 2016.
APA
Momozono, H., Miyake, H., Tei, H., Harada, K., & Fujisawa, M. (2016). Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade. Molecular and Clinical Oncology, 4, 839-844. https://doi.org/10.3892/mco.2016.817
MLA
Momozono, H., Miyake, H., Tei, H., Harada, K., Fujisawa, M."Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade". Molecular and Clinical Oncology 4.5 (2016): 839-844.
Chicago
Momozono, H., Miyake, H., Tei, H., Harada, K., Fujisawa, M."Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade". Molecular and Clinical Oncology 4, no. 5 (2016): 839-844. https://doi.org/10.3892/mco.2016.817
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