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Molecular and Clinical Oncology
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June-2016 Volume 4 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

A multicenter clinical study to determine the feasible initial dose of lenalidomide for maintenance therapy in patients with multiple myeloma following autologous peripheral blood stem‑cell transplantation

  • Authors:
    • Masahide Yamamoto
    • Kazuteru Ohashi
    • Kazuhiko Kakihana
    • Yuichi Nakamura
    • Takuya Komeno
    • Hiroshi Kojima
    • Satoshi Morita
    • Hisashi Sakamaki
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tokyo Medical and Dental University, Tokyo 113‑0034, Japan, Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo 113‑8677, Japan, Department of Hematology, Saitama Medical University Hospital, Iruma, Saitama 350‑0495, Japan, Department of Hematology, Mito Medical Center, National Hospital Organization, Mito, Ibaraki 311‑3193, Japan, Department of Clinical Oncology, Ibaraki Prefectural Central Hospital, Ibaraki Clinical Education and Training Center, University of Tsukuba Hospital, Tsukuba, Ibaraki 305‑8576, Japan, Biomedical Statistics and Bioinformatics Graduate School of Medicine, Kyoto University, Kyoto 606‑8502, Japan
  • Pages: 965-970
    |
    Published online on: March 28, 2016
       https://doi.org/10.3892/mco.2016.833
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Abstract

Maintenance therapy with lenalidomide (LEN) for patients with multiple myeloma (MM) following autologous peripheral blood stem cell transplantation (auto‑PBSCT) may be a promising option for preventing relapse or disease progression. However, the recommended dose of LEN has yet to be firmly established. We herein report the results of a multicenter clinical study for determining the feasible initial dose (FID) of LEN. In this trial, a total of 11 patients who achieved a very good partial response or complete response following auto‑PBSCT were enrolled from five transplant centers in Japan. Three dose levels of LEN (level 0, 5 mg; level 1, 10 mg; and level 2, :15 mg) were tested in this study. FID was defined as the maximum estimated dose at which 70% of the patients could receive maintenance therapy for 12 weeks without any serious adverse events or disease progression. Using a continual reassessment method, 6 patients were assigned to level 0 and the remaining 5 patients were assigned to level 1. All 6 patients (100%) at level 0, but only 2 patients (40%) at level 1, completed 12 weeks of administration with their assigned dose of LEN. The results of our study demonstrated that, although 5 mg of LEN was acceptable in terms of safety, 7.5 mg of LEN may also be an acceptable FID.
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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto M, Ohashi K, Kakihana K, Nakamura Y, Komeno T, Kojima H, Morita S and Sakamaki H: A multicenter clinical study to determine the feasible initial dose of lenalidomide for maintenance therapy in patients with multiple myeloma following autologous peripheral blood stem‑cell transplantation. Mol Clin Oncol 4: 965-970, 2016.
APA
Yamamoto, M., Ohashi, K., Kakihana, K., Nakamura, Y., Komeno, T., Kojima, H. ... Sakamaki, H. (2016). A multicenter clinical study to determine the feasible initial dose of lenalidomide for maintenance therapy in patients with multiple myeloma following autologous peripheral blood stem‑cell transplantation. Molecular and Clinical Oncology, 4, 965-970. https://doi.org/10.3892/mco.2016.833
MLA
Yamamoto, M., Ohashi, K., Kakihana, K., Nakamura, Y., Komeno, T., Kojima, H., Morita, S., Sakamaki, H."A multicenter clinical study to determine the feasible initial dose of lenalidomide for maintenance therapy in patients with multiple myeloma following autologous peripheral blood stem‑cell transplantation". Molecular and Clinical Oncology 4.6 (2016): 965-970.
Chicago
Yamamoto, M., Ohashi, K., Kakihana, K., Nakamura, Y., Komeno, T., Kojima, H., Morita, S., Sakamaki, H."A multicenter clinical study to determine the feasible initial dose of lenalidomide for maintenance therapy in patients with multiple myeloma following autologous peripheral blood stem‑cell transplantation". Molecular and Clinical Oncology 4, no. 6 (2016): 965-970. https://doi.org/10.3892/mco.2016.833
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto M, Ohashi K, Kakihana K, Nakamura Y, Komeno T, Kojima H, Morita S and Sakamaki H: A multicenter clinical study to determine the feasible initial dose of lenalidomide for maintenance therapy in patients with multiple myeloma following autologous peripheral blood stem‑cell transplantation. Mol Clin Oncol 4: 965-970, 2016.
APA
Yamamoto, M., Ohashi, K., Kakihana, K., Nakamura, Y., Komeno, T., Kojima, H. ... Sakamaki, H. (2016). A multicenter clinical study to determine the feasible initial dose of lenalidomide for maintenance therapy in patients with multiple myeloma following autologous peripheral blood stem‑cell transplantation. Molecular and Clinical Oncology, 4, 965-970. https://doi.org/10.3892/mco.2016.833
MLA
Yamamoto, M., Ohashi, K., Kakihana, K., Nakamura, Y., Komeno, T., Kojima, H., Morita, S., Sakamaki, H."A multicenter clinical study to determine the feasible initial dose of lenalidomide for maintenance therapy in patients with multiple myeloma following autologous peripheral blood stem‑cell transplantation". Molecular and Clinical Oncology 4.6 (2016): 965-970.
Chicago
Yamamoto, M., Ohashi, K., Kakihana, K., Nakamura, Y., Komeno, T., Kojima, H., Morita, S., Sakamaki, H."A multicenter clinical study to determine the feasible initial dose of lenalidomide for maintenance therapy in patients with multiple myeloma following autologous peripheral blood stem‑cell transplantation". Molecular and Clinical Oncology 4, no. 6 (2016): 965-970. https://doi.org/10.3892/mco.2016.833
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