Sialoblastoma of the cheek: A case report and review of the literature Corrigendum in /10.3892/mco.2016.1060

Sitthichaiyakul,Peerayut; Somran,Julintorn; Oilmungmool,Nongluk; Worasakwuttipong,Saran; Larbcharoensub,Noppadol

doi:10.3892/mco.2016.840

June-2016 Volume 4 Issue 6

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June-2016 Volume 4 Issue 6

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Case Report Open Access

Sialoblastoma of the cheek: A case report and review of the literature

Corrigendum in: /10.3892/mco.2016.1060

Authors:
- Peerayut Sitthichaiyakul
- Julintorn Somran
- Nongluk Oilmungmool
- Saran Worasakwuttipong
- Noppadol Larbcharoensub
View Affiliations / Copyright

Affiliations: Department of Pathology, Faculty of Medicine, Naresuan University, Phitsanulok 65000, Thailand, Department of Radiology, Faculty of Medicine, Naresuan University, Phitsanulok 65000, Thailand, Department of Surgery, Faculty of Medicine, Naresuan University, Phitsanulok 65000, Thailand, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

Copyright: © Sitthichaiyakul et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 925-928
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Published online on: March 30, 2016

https://doi.org/10.3892/mco.2016.840
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Abstract

Sialoblastoma is a rare salivary gland tumor that recapitulates the primitive salivary gland anlage. The authors herein report a case of sialoblastoma of a minor salivary gland, clinically presenting with progressive enlargement of a mass in the cheek of a 1‑year‑old female infant. Histopathologically, the mass consisted of tight clusters of basaloid cells and partially formed ductal and pseudo‑ductal spaces separated by thin fibrous bands. Immunohistchemical studies demonstrated the presence of cytokeratin AE1̸AE3, p63, CD99, α‑fetoprotein (AFP) and Hep Par‑1 expression in a considerable number of tumor cells. The clinical and pathological characteristics are presented and relevant literature is reviewed. Early complete surgical excision is recommended for the treatment of sialoblastoma. Radiation may be considered in cases with incomplete resection of the tumor. Chemotherapy may play a vital role in extensive, metastatic, or relapsed cases, or in cases with inadequate excision. The follow‑up treatment should be frequent and prolonged. To the best of our knowledge, this is the first reported case of sialoblastoma of the cheek with immunoreactivity for AFP and Hep Par‑1, which may be associated with the embryonic origin of the tumor. AFP may be a useful marker of tumor response in patient with sialoblastoma.

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1	Brandwein M, Said-Al-Naeif N, Manwani D, Som P, Goldfeder L, Rothschild M and Granowetter L: Sialoblastoma: Clinicopathological/immunohistochemical study. Am J Surg Pathol. 23:342–348. 1999. View Article : Google Scholar : PubMed/NCBI
2	Vidyadhar M, Amanda C, Thuan Q and Prabhakaran K: Sialoblastoma. J Pediatr Surg. 43:e11–e13. 2008. View Article : Google Scholar : PubMed/NCBI
3	Marucci DD, Lawson K, Harper J, Sebire NJ and Dunaway DJ: Sialoblastoma arising in ectopic salivary gland tissue. J Plast Reconst Aesthet Surg. 62:e241–e246. 2009. View Article : Google Scholar
4	Taylor GP: Congenital epithelial tumor of the parotid - sialoblastoma. Pediatr Pathol. 8:447–452. 1988. View Article : Google Scholar : PubMed/NCBI
5	Ellis GL: What's new in the AFIP fascicle on salivary gland tumors: A few highlights from the 4th Series Atlas. Head Neck Pathol. 3:225–230. 2009. View Article : Google Scholar : PubMed/NCBI
6	Eken M, Altin G, Aydin S, Hardal U and Sanli A: Sialoblastoma of the parotid gland. Int J Pediatr Otorhinolaryngol Extra. 5:63–65. 2010. View Article : Google Scholar
7	Mostafapour SP, Folz B, Barlow D and Manning S: Sialoblastoma of the submandibular gland: Report of a case and review of the literature. Int J Pediatr Otorhinolaryngol. 53:157–161. 2000. View Article : Google Scholar : PubMed/NCBI
8	Fuchsmann C, Viremouneix L, Collardeau-Frachon S, Ayari-Khalfallah S, Bouvier R, Guibaud L, et al: Management and treatment of a sialoblastoma of the submandibular gland in a neonate. Int J Pediatr Otorhinolaryngol Extra. 6:9–12. 2011. View Article : Google Scholar
9	Prigent M, Teissier N, Peuchmaur M, El Maleh-Berges M, Philippe-Chomette P, Cardin P and Orbach D: Sialoblastoma of salivary glands in children: Chemotherapy should be discussed as an alternative to mutilating surgery. Int J Pediatr Otorhinolaryngol. 74:942–945. 2010. View Article : Google Scholar : PubMed/NCBI
10	Williams SB, Ellis GL and Warnock GR: Sialoblastoma: A clinicopathologic and immunohistochemical study of 7 cases. Ann Diagn Pathol. 10:320–326. 2006. View Article : Google Scholar : PubMed/NCBI
11	Ersoz S, Turgutalp H, Cobanoglu U, Bektas D and Yaris N: Sialoblastoma in the parotid gland: A case report. Pediatr Int. 52:670–672. 2010. View Article : Google Scholar : PubMed/NCBI
12	Dardick I, Daley TD and McComb RJ: Sialoblastoma in adults: Distinction from adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 109:109–116. 2010. View Article : Google Scholar : PubMed/NCBI
13	Ozdemir I, Simsek E, Silan F and Demirci F: Congenital sialoblastoma (embryoma) associated with premature centromere division and high level of alpha-fetoprotein. Prenat Diagn. 25:687–689. 2005. View Article : Google Scholar : PubMed/NCBI
14	Mertens F, Wahlberg P and Domanski HA: Clonal chromosome aberrations in a sialoblastoma. Cancer Genet Cytogenet. 189:68–69. 2009. View Article : Google Scholar : PubMed/NCBI
15	Karaman E, Duman C, Cansız H, Yildiz I, Dervişoglu S and Ozdemir G: Sialoblastoma in cheek region: Report of a case. Int J Pediatr Otorhinolaryngol Extra. 5:47–49. 2010. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Sialoblastoma of the cheek: A case report and review of the literature

Corrigendum in: /10.3892/mco.2016.1060

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Abstract

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