Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
June-2016 Volume 4 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2016 Volume 4 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

CCND1 G870A polymorphism and colorectal cancer risk: An updated meta‑analysis

  • Authors:
    • Xiao‑Ming Xu
    • Xiao‑Bing Ni
    • Gong‑Li Yang
    • Zhi‑Guo Luo
    • Yu‑Ming Niu
    • Ming Shen
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology and Center for Evidence‑Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Jiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 1078-1084
    |
    Published online on: April 4, 2016
       https://doi.org/10.3892/mco.2016.844
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Molecular epidemiological studies have revealed a closer association between cyclin D1 (CCND1) polymorphism and the risk of colorectal cancer; however, the results were inconsistent. The aim of the present meta‑analysis was to investigate the association between CCND1 G870A polymorphism and colorectal cancer risk. Online electronic databases (PubMed and Embase) were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between CCND1 G870A polymorphism and the risk of colorectal cancer. In addition, heterogeneity, publication bias and sensitivity analysis were performed to guarantee the statistical power. In total, 23 published case‑control studies with 6,320 patients and 8,252 controls were selected. Significantly increased risks were observed in four genetic models (A vs. G: OR=1.09, 95% CI=1.00‑1.18, I2=54.3%; GA vs. GG: OR=1.13, 95% CI=1.04‑1.24, I2=18.2%; AA vs. GG, OR=1.17: 95% CI=1.00‑1.38, I2=52.5%; GA+AA vs. GG: OR=1.14, 95% CI=1.05‑1.24, I2=33.8%). Similarly, significant associations were also identified in the stratified analysis in the cancer subtype of sporadic colorectal cancer (GA vs. GG: OR=1.21, 95% CI=1.04‑1.42, I2=24.1%; GA+AA vs. GG: OR=1.18, 95% CI=1.02‑1.37, I2=35.0%), Caucasian population (GA vs. GG, OR=1.14, 95% CI=1.02‑1.28, I2=19.8%; GA+AA vs. GG, OR=1.14, 95% CI=1.02‑1.27, I2=37.5%) and other subgroups of control design and genotyping type. The present updated meta‑analysis suggested that CCND1 G870A may present an increased risk for developing colorectal cancer, particularly in sporadic colorectal cancer and a Caucasian population.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Brevik A, Joshi AD, Corral R, Onland-Moret NC, Siegmund KD, Le Marchand L, Baron JA, Martinez ME, Haile RW, Ahnen DJ, et al: Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. Cancer Epidemiol Biomarkers Prev. 19:3167–3173. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Lynch PM: The hMSH2 and hMLH1 genes in hereditary nonpolyposis colorectal cancer. Surg Oncol Clin N Am. 18:611–624. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Shin MH, Holmes MD, Hankinson SE, Wu K, Colditz GA and Willett WC: Intake of dairy products, calcium and vitamin d and risk of breast cancer. J Natl Cancer Inst. 94:1301–1311. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Sherr CJ: Cancer cell cycles. Science. 274:1672–1677. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Kaminagakura E, da Werneck Cunha I, Soares FA, Nishimoto IN and Kowalski LP: CCND1 amplification and protein overexpression in oral squamous cell carcinoma of young patients. Head Neck. 33:1413–1419. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Troncone G, Volante M, Iaccarino A, Zeppa P, Cozzolino I, Malapelle U, Palmieri EA, Conzo G, Papotti M and Palombini L: Cyclin D1 and D3 overexpression predicts malignant behavior in thyroid fine-needle aspirates suspicious for Hurthle cell neoplasms. Cancer. 117:522–529. 2009.PubMed/NCBI

8 

Abramson VG, Troxel AB, Feldman M, Mies C, Wang Y, Sherman L, McNally S, Diehl A and Demichele A: Cyclin D1b in human breast carcinoma and coexpression with cyclin D1a is associated with poor outcome. Anticancer Res. 30:1279–1285. 2010.PubMed/NCBI

9 

Zhang L, Chen LM, Wang MN, Chen XJ, Li N, Huang YD and Chen M: The G894t, T-786c and 4b/a polymorphisms in Enos gene and cancer risk: A meta-analysis. J Evid Based Med. 7:263–269. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WD and Heighway J: Alternate splicing produces a novel cyclin D1 transcript. Oncogene. 11:1005–1011. 1995.PubMed/NCBI

11 

Kong S, Amos CI, Luthra R, Lynch PM, Levin B and Frazier ML: Effects of cyclin D1 polymorphism on age of onset of hereditary nonpolyposis colorectal cancer. Cancer Res. 60:249–252. 2000.PubMed/NCBI

12 

Moher D, Liberati A, Tetzlaff J and Altman DG: Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ. 339:b25352009. View Article : Google Scholar : PubMed/NCBI

13 

Little J, Bradley L, Bray MS, Clyne M, Dorman J, Ellsworth DL, Hanson J, Khoury M, Lau J, O'Brien TR, et al: Reporting, appraising and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol. 156:300–310. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Zhang Y, Jia Q, Xue P, Liu Y, Xiong T, Yang J, Song C, He Q and Du L: The-786T>C polymorphism in the NOS3 gene is associated with increased cancer risk. Tumour Biol. 35:3535–3540. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Lau J, Ioannidis JP and Schmid CH: Quantitative synthesis in systematic reviews. Ann Intern Med. 127:820–826. 1997. View Article : Google Scholar : PubMed/NCBI

16 

DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI

17 

Mantel N and Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 22:719–748. 1959.PubMed/NCBI

18 

Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Bagos PG and Nikolopoulos GK: Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology. J Clin Epidemiol. 62:1037–1044. 2009. View Article : Google Scholar : PubMed/NCBI

20 

McKay JA, Douglas JJ, Ross VG, Curran S, Murray GI, Cassidy J and McLeod HL: Cyclin D1 protein expression and gene polymorphism in colorectal cancer. Aberdeen colorectal initiative. Int J Cancer. 88:77–81. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Kong S, Wei Q, Amos CI, Lynch PM, Levin B, Zong J and Frazier ML: Cyclin D1 polymorphism and increased risk of colorectal cancer at young age. J Natl Cancer Inst. 93:1106–1108. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Bala S and Peltomäki P: Cyclin D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer. Cancer Res. 61:6042–6045. 2001.PubMed/NCBI

23 

Porter TR, Richards FM, Houlston RS, Evans DG, Jankowski JA, Macdonald F, Norbury G, Payne SJ, Fisher SA, Tomlinson I and Maher ER: Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. Oncogene. 21:1928–1933. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Le Marchand L, Seifried A, Lum-Jones A, Donlon T and Wilkens LR: Association of the cyclin D1 A870G polymorphism with advanced colorectal cancer. JAMA. 290:2843–2848. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Grieu F, Malaney S, Ward R, Joseph D and Iacopetta B: Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers. Anticancer Res. 23:4257–4259. 2003.PubMed/NCBI

26 

Hong Y, Eu KW, Seow-Choen F, Fook-Chong S and Cheah PY: GG genotype of cyclin D1 G870A polymorphism is associated with increased risk and advanced colorectal cancer in patients in Singapore. Eur J Cancer. 41:1037–1044. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Jiang J, Wang J, Suzuki S, Gajalakshmi V, Kuriki K, Zhao Y, Nakamura S, Akasaka S, Ishikawa H and Tokudome S: Elevated risk of colorectal cancer associated with the AA genotype of the cyclin D1 A870G polymorphism in an Indian population. J Cancer Res Clin Oncol. 132:193–199. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Schernhammer ES, Tranah GJ, Giovannucci E, Chan AT, Ma J, Colditz GA, Hunter DJ, Willett WC and Fuchs CS: Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma. Br J Cancer. 94:928–934. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Huang WS, Tang R, Lin PY, Changchien CR, Chen JS, Chiang JM, Yeh CY, Wang JY and Hsieh LL: Impact of the cyclin D1 A870G polymorphism on susceptibility to sporadic colorectal cancer in Taiwan. Dis Colon Rectum. 49:602–608. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Probst-Hensch NM, Sun CL, Van Den Berg D, Ceschi M, Koh WP and Yu MC: The effect of the cyclin D1 (CCND1) A870G polymorphism on colorectal cancer risk is modified by glutathione-S-transferase polymorphisms and isothiocyanate intake in the Singapore Chinese health study. Carcinogenesis. 27:2475–2482. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Krüger S, Engel C, Bier A, Mangold E, Pagenstecher C, Doeberitz Mv, Holinski-Feder E, Moeslein G, Keller G, Kunstmann E, et al: Absence of association between cyclin D1 (CCND1) G870A polymorphism and age of onset in hereditary nonpolyposis colorectal cancer. Cancer Lett. 236:191–197. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Grünhage F, Jungck M, Lamberti C, Berg C, Becker U, Schulte-Witte H, Plassmann D, Rahner N, Aretz S, Friedrichs N, et al: Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes. Int J Colorectal Dis. 23:147–154. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Tan XL, Nieters A, Kropp S, Hoffmeister M, Brenner H and Chang-Claude J: The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis. Int J Cancer. 122:2573–2580. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Forones NM, de Lima JM, de Souza LG and da Silva ID: Cyclin D1 A870G polymorphism in Brazilian colorectal cancer patients. J Gastrointest Cancer. 39:118–123. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Liu B, Zhang Y, Jin M, Ni Q, Liang X, Ma X, Yao K, Li Q and Chen K: Association of selected polymorphisms of CCND1, p21 and caspase8 with colorectal cancer risk. Mol Carcinog. 49:75–84. 2010.PubMed/NCBI

36 

Kanaan Z, Eichenberger MR, Young M, Colliver D, Crawford N, Cobbs GA, Hein DW and Galandiuk S: An alternative cyclin-D1 splice site is not linked to inflammatory bowel disease-associated neoplasia. Int J Biol Markers. 25:27–31. 2010.PubMed/NCBI

37 

Yaylim-Eraltan I, Arikan S, Yildiz Y, Cacina C, Ergen HA, Tuna G, Görmüs U, Zeybek U and Isbir T: The influence of cyclin D1 A870G polymorphism on colorectal cancer risk and prognosis in a Turkish population. Anticancer Res. 30:2875–2880. 2010.PubMed/NCBI

38 

Jelonek K, Gdowicz-Klosok A, Pietrowska M, Borkowska M, Korfanty J, Rzeszowska-Wolny J and Widlak P: Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck and breast cancers in a Polish population. J Appl Genet. 51:343–352. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Talseth BA, Ashton KA, Meldrum C, Suchy J, Kurzawski G, Lubinski J and Scott RJ: Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. Int J Cancer. 122:1273–1277. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Sameer AS, Parray FQ, Dar MA, Nissar S, Banday MZ, Rasool S, Gulzar GM, Chowdri NA and Siddiqi MA: Cyclin D1 G870A polymorphism and risk of colorectal cancer: A case control study. Mol Med Rep. 7:811–815. 2013.PubMed/NCBI

41 

Govatati S, Singamsetty GK, Nallabelli N, Malempati S, Rao PS, Madamchetty VK, Govatati S, Kanapuram R, Narayana N, Bhanoori M, et al: Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) alterations to colorectal cancer susceptibility: A case-control study. Tumour Biol. 35:12059–12067. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Hall M and Peters G: Genetic alterations of cyclins, cyclin-dependent kinases and Cdk inhibitors in human cancer. Adv Cancer Res. 68:67–108. 1996. View Article : Google Scholar : PubMed/NCBI

43 

Solomon DA, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Conti CJ and Knudsen ES: Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation and cellular transformation. J Biol Chem. 278:30339–30347. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Onay UV, Aaltonen K, Briollais L, Knight JA, Pabalan N, Kilpivaara O, Andrulis IL, Blomqvist C, Nevanlinna H and Ozcelik H: Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk. BMC Cancer. 8:62008. View Article : Google Scholar : PubMed/NCBI

45 

Mandal RK and Mittal RD: Are cell cycle and apoptosis genes associated with prostate cancer risk in North Indian population? Urol Oncol. 30:555–561. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Casson AG, Zheng Z, Evans SC, Geldenhuys L, van Zanten SV, Veugelers PJ, Porter GA and Guernsey DL: Cyclin D1 polymorphism (G870A) and risk for esophageal adenocarcinoma. Cancer. 104:730–739. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu XM, Ni XB, Yang GL, Luo ZG, Niu YM and Shen M: CCND1 G870A polymorphism and colorectal cancer risk: An updated meta‑analysis. Mol Clin Oncol 4: 1078-1084, 2016.
APA
Xu, X., Ni, X., Yang, G., Luo, Z., Niu, Y., & Shen, M. (2016). CCND1 G870A polymorphism and colorectal cancer risk: An updated meta‑analysis. Molecular and Clinical Oncology, 4, 1078-1084. https://doi.org/10.3892/mco.2016.844
MLA
Xu, X., Ni, X., Yang, G., Luo, Z., Niu, Y., Shen, M."CCND1 G870A polymorphism and colorectal cancer risk: An updated meta‑analysis". Molecular and Clinical Oncology 4.6 (2016): 1078-1084.
Chicago
Xu, X., Ni, X., Yang, G., Luo, Z., Niu, Y., Shen, M."CCND1 G870A polymorphism and colorectal cancer risk: An updated meta‑analysis". Molecular and Clinical Oncology 4, no. 6 (2016): 1078-1084. https://doi.org/10.3892/mco.2016.844
Copy and paste a formatted citation
x
Spandidos Publications style
Xu XM, Ni XB, Yang GL, Luo ZG, Niu YM and Shen M: CCND1 G870A polymorphism and colorectal cancer risk: An updated meta‑analysis. Mol Clin Oncol 4: 1078-1084, 2016.
APA
Xu, X., Ni, X., Yang, G., Luo, Z., Niu, Y., & Shen, M. (2016). CCND1 G870A polymorphism and colorectal cancer risk: An updated meta‑analysis. Molecular and Clinical Oncology, 4, 1078-1084. https://doi.org/10.3892/mco.2016.844
MLA
Xu, X., Ni, X., Yang, G., Luo, Z., Niu, Y., Shen, M."CCND1 G870A polymorphism and colorectal cancer risk: An updated meta‑analysis". Molecular and Clinical Oncology 4.6 (2016): 1078-1084.
Chicago
Xu, X., Ni, X., Yang, G., Luo, Z., Niu, Y., Shen, M."CCND1 G870A polymorphism and colorectal cancer risk: An updated meta‑analysis". Molecular and Clinical Oncology 4, no. 6 (2016): 1078-1084. https://doi.org/10.3892/mco.2016.844
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team