Development of multiple malignancies following long‑term glucocorticoid therapy in a patient with leukocytoclastic vasculitis: A case report

Fang,Lianghua; Hu,Yue; Wang,Wei; Hu,Shouyou; Zhang,Li; Wang,Ruiping

doi:10.3892/mco.2016.854

June-2016 Volume 4 Issue 6

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June-2016 Volume 4 Issue 6

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Case Report Open Access

Development of multiple malignancies following long‑term glucocorticoid therapy in a patient with leukocytoclastic vasculitis: A case report

Authors:
- Lianghua Fang
- Yue Hu
- Wei Wang
- Shouyou Hu
- Li Zhang
- Ruiping Wang
View Affiliations / Copyright

Affiliations: Department of Oncology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China, Department of Hematopathology, MD Anderson Cancer Center, Houston, TX 77030, USA

Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 929-932
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Published online on: April 7, 2016

https://doi.org/10.3892/mco.2016.854
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Abstract

Leukocytoclastic vasculitis (LCV) is a neutrophilic inflammation of the blood vessels. LCV may present as a paraneoplastic syndrome occurring before, synchronously with, or after the diagnosis of malignancy. In this study, we report a unique case of multiple malignancies developing simultaneously in a patient with a long history of LCV. The patient was originally diagnosed with LCV and received long‑term glucocorticoid treatment. After 11 years of therapy, the patient developed three primary malignancies, including small‑cell lung carcinoma, gastric adenocarcinoma and colonic adenocarcinoma. It is likely that LCV was not a paraneoplastic syndrome in this case, but rather an independent process, and the development of multiple cancers is likely associated with the long‑term glucocorticoid treatment, which caused imbalance of the immune system. Although the development of cancer during the course of glucocorticoid treatment is very rare, clinicians must be aware of this possible association and immunodysregulation may play a role in this context.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Development of multiple malignancies following long‑term glucocorticoid therapy in a patient with leukocytoclastic vasculitis: A case report

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