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Molecular and Clinical Oncology
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Review

Novel therapeutic options for second-line therapy in metastatic renal cell carcinoma (Review)

  • Authors:
    • Christoph‑A. J. von Klot
    • Axel S. Merseburger
    • Markus A. Kuczyk
  • View Affiliations / Copyright

    Affiliations: Department of Urology and Urological Oncology, Hannover University Medical School, D‑30625 Hannover, Germany, Department of Urology, Campus Lübeck University Hospital Schleswig‑Holstein, D‑23538 Lübeck, Germany
  • Pages: 903-908
    |
    Published online on: April 8, 2016
       https://doi.org/10.3892/mco.2016.856
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Abstract

Metastatic renal cell carcinoma (mRCC) has gained a variety of therapeutic options since the introduction of targeted therapy, starting in 2007. The basic molecular mechanisms included predominantly the targeting of vascular endothelial growth factor or the inhibition of the mammalian target of rapamycin. Recently, results from two randomized controlled trials, the CheckMate‑25 and the METEOR trial, regarding therapy for RCC in the second‑line setting have been published. In the present review, the current status of second‑line therapy in mRCC is discussed, together with results from the two newly introduced substances, nivolumab and cabozantinib.
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1 

European Network of Cancer Registries (ENCR): Eurocim. Version 4.0. European incidence database v2.3, 730 entity dictionary. Lyon: ENCR. 2001.

2 

Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, Forman D and Bray F: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer. 49:1374–1403. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Katz DL, Zheng T, Holford TR and Flannery J: Time trends in the incidence of renal carcinoma: Analysis of connecticut tumor registry data, 1935–1989. Int J Cancer. 58:57–63. 1994. View Article : Google Scholar : PubMed/NCBI

4 

Fisher R, Gore M and Larkin J: Current and future systemic treatments for renal cell carcinoma. Semin Cancer Biol. 23:38–45. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Kroeger N, Choueiri TK, Lee J-L, Bjarnason GA, Knox JJ, MacKenzie MJ, Wood L, Srinivas S, Vaishamayan UN, Rha SY, et al: Survival outcome and treatment response of patients with late relapse from renal cell carcinoma in the era of targeted therapy. Eur Urol. 65:1086–1092. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Keegan KA, Schupp CW, Chamie K, Hellenthal NJ, Evans CP and Koppie TM: Histopathology of surgically treated renal cell carcinoma: Survival differences by subtype and stage. J Urol. 188:391–397. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Franklin JR, Figlin R, Rauch J, Gitlitz B and Belldegrun A: Cytoreductive surgery in the management of metastatic renal cell carcinoma: The UCLA experience. Semin Urol Oncol. 14:230–236. 1996.PubMed/NCBI

8 

Sarna G, Figlin R and de Kernion J: Interferon in renal cell carcinoma. The UCLA experience. Cancer. 59(Suppl 3): 610–612. 1987. View Article : Google Scholar : PubMed/NCBI

9 

Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, et al: Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 27:3584–3590. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, et al: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 356:115–124. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J, Nathan P, Staehler M, de Souza P, Merchan JR, et al: Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med. 369:722–731. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Motzer RJ, Escudier B, Tomczak P, Hutson TE, Michaelson MD, Negrier S, Oudard S, Gore ME, Tarazi J, Hariharan S, et al: Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol. 14:552–562. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, et al: TARGET Study Group: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 356:125–134. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, Barrios CH, Salman P, Gladkov OA, Kavina A, et al: Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol. 28:1061–1068. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Grünwald V, Thompson JA, Figlin RA, Hollaender N, et al: RECORD-1 Study Group: Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet. 372:449–456. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Ljungberg B (chair), Bensalah K, Bex A (vice-chair), Canfield S, Dabestani S, Hofmann F, Hora M, Kuczyk MA, Lam T, Marconi L, et al: Guidelines on Renal Cell Carcinoma. European Association of Urology. 2015.

17 

Hutson TE, Escudier B, Esteban E, Bjarnason GA, Lim HY, Pittman KB, Senico P, Niethammer A, Lu DR, Hariharan S, et al: Randomized phase III trial of temsirolimus versus sorafenib as second-line therapy after sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol. 32:760–767. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Motzer RJ, Barrios CH, Kim TM, Falcon S, Cosgriff T, Harker WG, Srimuninnimit V, Pittman K, Sabbatini R, Rha SY, et al: Phase II randomized trial comparing sequential first-line everolimus and second-line sunitinib versus first-line sunitinib and second-line everolimus in patients with metastatic renal cell carcinoma. J Clin Oncol. 32:2765–2772. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Escudier B, Porta C, Schmidinger M, Algaba F, Patard JJ, Khoo V, Eisen T and Horwich A: ESMO Guidelines Working Group: Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 25(Suppl 3): iii49–iii56. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, et al: CheckMate 025 Investigators: Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med. 373:1803–1813. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Choueiri TK, Escudier B, Powles T, Mainwaring PN, Rini BI, Donskov F, Hammers H, Hutson TE, Lee J-L, Peltola K, et al: METEOR Investigators: Cabozantinib versus everolimus in advanced renal-cell carcinoma. N Engl J Med. 373:1814–1823. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Hamid O and Carvajal RD: Anti-programmed death-1 and anti-programmed death-ligand 1 antibodies in cancer therapy. Expert Opin Biol Ther. 13:847–861. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, Higuchi T, Yagi H, Takakura K, Minato N, et al: Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci USA. 104:3360–3365. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Motzer RJ, Bacik J, Schwartz LH, Reuter V, Russo P, Marion S and Mazumdar M: Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol. 22:454–463. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Cella D, Yount S, Brucker PS, Du H, Bukowski R, Vogelzang N and Bro WP: Development and validation of a scale to measure disease-related symptoms of kidney cancer. Value Health. 10:285–293. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Motzer RJ, Sharma P, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, et al: CheckMate 025 phase iII trial: Outcomes by key baseline factors and prior therapy for nivolumab (nIVO) versus everolimus (eVE) in advanced renal cell carcinoma (rCC). J Clin Oncol. 34(Suppl 2S): Abstr 498. 2016.

27 

Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, Webster WS, Krejci KG, Lobo JR, Sengupta S, Chen L, et al: Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci USA. 101:17174–17179. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Omori S, Kenmotsu H, Abe M, Watanabe R, Sugino T, Wakuda K, Ono A, Taira T, Naito T, Murakami H, et al: Changes in pD-l1 expression in non-small cell lung cancer by immunohistochemical analysis. J Clin Oncol. 33:Abstr e22118. 2015.

29 

Gibney GT, Aziz SA, Camp RL, Conrad P, Schwartz BE, Chen CR, Kelly WK and Kluger HM: c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma. Ann Oncol. 24:343–349. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, et al: Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proc Natl Acad Sci USA. 111:13373–13378. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Viola D, Cappagli V and Elisei R: Cabozantinib (XL184) for the treatment of locally advanced or metastatic progressive medullary thyroid cancer. Future Oncol. 9:1083–1092. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Armstrong AJ, Broderick S, Eisen T, Stadler WM, Jones RJ, Garcia JA, Vaishampayan UN, Picus J, Hawkins RE, Hainsworth JD, et al: Final clinical results of a randomized phase II international trial of everolimus vs. sunitinib in patients with metastatic non-clear cell renal cell carcinoma (ASPEN). J Clin Oncol. 33:Abstr 4507. 2015.

33 

Heng DY, Mackenzie MJ, Vaishampayan UN, Bjarnason GA, Knox JJ, Tan MH, Wood L, Wang Y, Kollmannsberger C, North S, et al: Primary anti-vascular endothelial growth factor (VEGF)-refractory metastatic renal cell carcinoma: Clinical characteristics, risk factors, and subsequent therapy. Ann Oncol. 23:1549–1555. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Hales RK, Banchereau J, Ribas A, Tarhini AA, Weber JS, Fox BA and Drake CG: Assessing oncologic benefit in clinical trials of immunotherapy agents. Ann Oncol. 21:1944–1951. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Wolchok JD, Hoos A, O'Day S, Weber JS, Hamid O, Lebbé C, Maio M, Binder M, Bohnsack O, Nichol G, et al: Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria. Clin Cancer Res. 15:7412–7420. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, Eisenberger MA, Higano C, Bubley GJ, Dreicer R, et al: Prostate Cancer Clinical Trials Working Group: Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol. 26:1148–1159. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Corsello SM, Barnabei A, Marchetti P, De Vecchis L, Salvatori R and Torino F: Endocrine side effects induced by immune checkpoint inhibitors. J Clin Endocrinol Metab. 98:1361–1375. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Motzer RJ, Rini BI, McDermott DF, Redman BG, Kuzel TM, Harrison MR, Vaishampayan UN, Drabkin HA, George S, Logan TF, et al: Nivolumab for metastatic renal cell carcinoma: Results of a randomized phase iI trial. J Clin Oncol. 33:1430–1437. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Eichelberg C, Vervenne WL, De Santis M, et al: SWITCH: A randomised, sequential, open-label study to evaluate the efficacy and safety of sorafenib-sunitinib versus sunitinib-sorafenib in the treatment of metastatic renal cell cancer. Eur Urol. 68:837–847. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Grünwald V, Thompson JA, Figlin RA, Hollaender N, et al: RECORD-1 study group: Phase 3 trial of everolimus for metastatic renal cell carcinoma: Final results and analysis of prognostic factors. Cancer. 116:4256–4265. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
von Klot CAJ, Merseburger AS and Kuczyk MA: Novel therapeutic options for second-line therapy in metastatic renal cell carcinoma (Review). Mol Clin Oncol 4: 903-908, 2016.
APA
von Klot, C.J., Merseburger, A.S., & Kuczyk, M.A. (2016). Novel therapeutic options for second-line therapy in metastatic renal cell carcinoma (Review). Molecular and Clinical Oncology, 4, 903-908. https://doi.org/10.3892/mco.2016.856
MLA
von Klot, C. J., Merseburger, A. S., Kuczyk, M. A."Novel therapeutic options for second-line therapy in metastatic renal cell carcinoma (Review)". Molecular and Clinical Oncology 4.6 (2016): 903-908.
Chicago
von Klot, C. J., Merseburger, A. S., Kuczyk, M. A."Novel therapeutic options for second-line therapy in metastatic renal cell carcinoma (Review)". Molecular and Clinical Oncology 4, no. 6 (2016): 903-908. https://doi.org/10.3892/mco.2016.856
Copy and paste a formatted citation
x
Spandidos Publications style
von Klot CAJ, Merseburger AS and Kuczyk MA: Novel therapeutic options for second-line therapy in metastatic renal cell carcinoma (Review). Mol Clin Oncol 4: 903-908, 2016.
APA
von Klot, C.J., Merseburger, A.S., & Kuczyk, M.A. (2016). Novel therapeutic options for second-line therapy in metastatic renal cell carcinoma (Review). Molecular and Clinical Oncology, 4, 903-908. https://doi.org/10.3892/mco.2016.856
MLA
von Klot, C. J., Merseburger, A. S., Kuczyk, M. A."Novel therapeutic options for second-line therapy in metastatic renal cell carcinoma (Review)". Molecular and Clinical Oncology 4.6 (2016): 903-908.
Chicago
von Klot, C. J., Merseburger, A. S., Kuczyk, M. A."Novel therapeutic options for second-line therapy in metastatic renal cell carcinoma (Review)". Molecular and Clinical Oncology 4, no. 6 (2016): 903-908. https://doi.org/10.3892/mco.2016.856
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