Clinical significance of serum laminin and type‑IV collagen levels in cutaneous melanoma patients

Tas,Faruk; Bilgin,Elif; Karabulut,Senem; Duranyildiz,Derya

doi:10.3892/mco.2016.873

July-2016 Volume 5 Issue 1

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July-2016 Volume 5 Issue 1

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Article

Clinical significance of serum laminin and type‑IV collagen levels in cutaneous melanoma patients

Authors:
- Faruk Tas
- Elif Bilgin
- Senem Karabulut
- Derya Duranyildiz
View Affiliations / Copyright

Affiliations: Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul 34390, Turkey
Pages: 195-200
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Published online on: April 25, 2016

https://doi.org/10.3892/mco.2016.873
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Abstract

Laminin and type-IV collagen constitute a significant portion of the extracellular matrix. The objective of the present study was to evaluate whether the serum concentrations of laminin and type-IV collagen may serve as biomarkers for cutaneous melanoma. Sixty pathologically confirmed melanoma patients were enrolled in the study. Serum laminin and type‑IV collagen levels were assessed using an ELISA. Thirty healthy controls were also examined. No significant differences in the baseline serum levels of laminin were identified between melanoma patients and healthy controls (P=0.45). However, the baseline serum levels of type‑IV collagen were significantly elevated in melanoma patients compared with those in the control group (P<0.001). Clinical parameters, including patient age, gender, localization of lesion, histopathology, stage of disease, serum lactate dehydrogenase concentrations and responsiveness to chemotherapy were found not to be associated with the serum levels of laminin and type‑IV collagen (P>0.05). Furthermore, the serum levels of laminin and type‑IV collagen had no prognostic value regarding the outcome for melanoma patients (P=0.36 and P=0.26, respectively). While laminin levels showed no diagnostic value, the serum concentrations of type‑IV collagen were indicated to serve as a diagnostic marker in patients with cutaneous melanoma. In conclusion, type‑IV collagen levels may be used as a diagnostic marker for cutaneous melanoma, while being void of any prognostic value.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical significance of serum laminin and type‑IV collagen levels in cutaneous melanoma patients

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