Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2016 Volume 5 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2016 Volume 5 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma

  • Authors:
    • Masao Takenobu
    • Mitsuhiko Osaki
    • Kazunori Fujiwara
    • Takahiro Fukuhara
    • Hiroya Kitano
    • Hiroyuki Kugoh
    • Futoshi Okada
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8503, Japan, Division of Pathological Biochemistry, Department of Biomedical Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8503, Japan, Chromosome Engineering Research Center, Tottori University, Yonago, Tottori 683‑8503, Japan
  • Pages: 89-94
    |
    Published online on: April 28, 2016
       https://doi.org/10.3892/mco.2016.880
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The pituitary homeobox 1 (PITX1) protein is essential for developmental processes in humans. Previously, PITX1 was identified as a possible tumor suppressor gene in various types of human carcinoma. However, the association between PITX1 and human head and neck squamous cell carcinoma (HNSCC) remains to be elucidated. Immunohistochemical analysis was performed to examine the expression levels of PITX1 in 47 cases of HNSCC, and in 4 control cases. The expression of p53 was also examined in these cases. The labeling indices (LIs) were calculated, and the correlations between clinical factors (chemosensitivity, prognosis and the degree of differentiation) and the LIs were assessed. The PITX1 LI in HNSCC was 27.4±14.5%, which was significantly lower compared with the LIs of the control samples: 76.9±6.97% (P<0.05). Additionally, the PITX1 LIs were 39.9±6.2, 26.9±16.9 and 24.2±11.8% in the complete response (CR), partial response (PR), stable disease or progressive disease (SD/PD) groups, respectively. The PITX1 LI in the CR group revealed the highest result between the all groups, and it was significantly greater compared with that in the SD/PD group (P<0.01). The p53 LIs were 24.5±19.9, 25.7±16.9 and 19.8±13.8 in the CR, PR and SD/PD groups, respectively (P>0.05). Neither the PITX1 nor the p53 LIs were a statistically significant indicator of the prognosis. PITX1 is a candidate tumor suppressor gene and a possible predictive biomarker of chemosensitivity of human HNSCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1. 

Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar : PubMed/NCBI

2. 

Al-Sarraf M: Treatment of locally advanced head and neck cancer: Historical and critical review. Cancer Control. 9:387–399. 2002.PubMed/NCBI

3. 

Seiwert TY and Cohen EEW: State-of-the-art management of locally advanced head and neck cancer. Br J Cancer. 92:1341–1348. 2005. View Article : Google Scholar : PubMed/NCBI

4. 

Urba S, Wolf G, Eisbruch A, Worden F, Lee J, Bradford C, Teknos T, Chepeha D, Prince M, Hogikyan N and Taylor J: Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: A new treatment paradigm. J Clin Oncol. 24:593–598. 2006. View Article : Google Scholar : PubMed/NCBI

5. 

Lamonerie T, Tremblay JJ, Lanctôt C, Therrien M, Gauthier Y and Drouin J: Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes Dev. 10:1284–1295. 1996. View Article : Google Scholar : PubMed/NCBI

6. 

DeLaurier A, Schweitzer R and Logan M: Pitx1 determines the morphology of muscle, tendon and bones of the hindlimb. Dev Biol. 299:22–34. 2006. View Article : Google Scholar : PubMed/NCBI

7. 

Kolfschoten IGM, van Leeuwen B, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Voorhoeve PM and Agami R: A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell. 121:849–858. 2005. View Article : Google Scholar : PubMed/NCBI

8. 

Qi DL, Ohhira T, Fujisaki C, Inoue T, Ohta T, Osaki M, Ohshiro E, Seko T, Aoki S, Oshimura M and Kugoh H: Identification of PITX1 as a TERT suppressor gene located on human chromosome 5. Mol Cell Biol. 31:1624–1636. 2011. View Article : Google Scholar : PubMed/NCBI

9. 

Libório TN, Acquafreda T, Matizonkas-Antonio LF, Silva-Valenzuela MG, Ferraz AR and Nunes FD: In situ hybridization detection of homeobox genes reveals distinct expression patterns in oral squamous cell carcinomas. Histopathology. 58:225–233. 2011. View Article : Google Scholar : PubMed/NCBI

10. 

Osaki M, Chinen H, Yoshida Y, Ohhira T, Sunamura N, Yamamoto O, Ito H, Oshimura M and Kugoh H: Decreased PITX1 gene expression in human cutaneous malignant melanoma and its clinicopathological significance. Eur J Dermatol. 23:344–349. 2013.PubMed/NCBI

11. 

Lord RV, Brabender J, Wickramasinghe K, DeMeester SR, Holscher A, Schneider PM, Danenberg PV and DeMeester TR: Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. Surgery. 138:924–931. 2005. View Article : Google Scholar : PubMed/NCBI

12. 

Chen YN, Chen H, Xu Y, Zhang X and Luo Y: Expression of pituitary homeobox 1 gene in human gastric carcinogenesis and its clinicopathological significance. World J Gastroenterol. 14:292–297. 2008. View Article : Google Scholar : PubMed/NCBI

13. 

Chen Y, Knösel T, Ye F, Pacyna-Gengelbach M, Deutschmann N and Petersen I: Decreased PITX1 homeobox gene expression in human lung cancer. Lung Cancer. 55:287–294. 2007. View Article : Google Scholar : PubMed/NCBI

14. 

Stender JD, Stossi F, Funk CC, Charn TH, Barnett DH and Katzenellenbogen BS: The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells. Mol Endocrinol. 25:1699–1709. 2011. View Article : Google Scholar : PubMed/NCBI

15. 

Calvisi DF, Ladu S, Conner EA, Seo D, Hsieh JT, Factor VM and Thorgeirsson SS: Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. J Hepatol. 54:311–319. 2011. View Article : Google Scholar : PubMed/NCBI

16. 

Knösel T, Chen Y, Hotovy S, Settmacher U, Altendorf-Hofmann A and Petersen I: Loss of desmocollin 1–3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma. Int J Colorectal Dis. 27:1391–1399. 2012. View Article : Google Scholar : PubMed/NCBI

17. 

Kwok SC, Liu XM, Mangel P and Daskal I: PTX1 (ERGIC2)-VP22 fusion protein upregulates interferon-beta in prostate cancer cell line PC-3. DNA Cell Biol. 25:523–529. 2006. View Article : Google Scholar : PubMed/NCBI

18. 

Somers KD, Merrick MA, Lopez ME, Incognito LS, Schechter GL and Casey G: Frequent p53 mutations in head and neck cancer. Cancer Res. 52:5997–6000. 1992.PubMed/NCBI

19. 

Poeta M, Manola J, Goldwasser MA, Forastiere A, Benoit N, Califano JA, Ridge JA, Goodwin J, Kenady D, Saunders J, et al: TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 357:2552–2561. 2007. View Article : Google Scholar : PubMed/NCBI

20. 

Warnakulasuriya S, Jia C, Johnson N and Houghton J: p53 and P-glycoprotein expression are significant prognostic markers in advanced head and neck cancer treated with chemo/radiotherapy. J Pathol. 191:33–38. 2000. View Article : Google Scholar : PubMed/NCBI

21. 

Mannarini L, Bertino G, Morbini P, Villa C and Benazzo M: Markers of chemoradiation resistance in patients with locally advanced head and neck squamous cell carcinoma, treated by intra-arterial carboplatin and concurrent radiation. Acta Otorhinolaryngol Ital. 27:173–180. 2007.PubMed/NCBI

22. 

Temam S, Flahault A, Périé S, Monceaux G, Coulet F, Callard P, Bernaudin JF, St Guily JL and Fouret P: P53 gene status as a predictor of tumor response to induction chemotherapy of patients with locoregionally advanced squamous cell carcinomas of the head and neck. J Clin Oncol. 18:385–394. 2000.PubMed/NCBI

23. 

Okumura K, Hasegawa Y, Harada H, Ishizaki K and Murakami S: A comparative study of p53 status and clinical response to chemotherapy in head and neck cancer. Nagoya Med J. 46:171–180. 2003.

24. 

Szentkúti G, Dános K, Brauswetter D, Kiszner G, Krenács T, Csákó L, Répássy G and Tamás L: Correlations between prognosis and regional biomarker profiles in head and neck squamous cell carcinomas. Pathol Oncol Res. 21:643–650. 2015. View Article : Google Scholar : PubMed/NCBI

25. 

Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweji J, Van Glabbeke M, van Oosterom AT, Christian MC and Gwyther SG: New guldelines to evaluate the response to treatment in solod tumors. J Natl Cancer Inst. 92:205–216. 2000. View Article : Google Scholar : PubMed/NCBI

26. 

Nakashima T, Maehara Y, Kohnoe S, Hayashi I and Katsuta Y: Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas. Head Neck. 12:406–410. 1990. View Article : Google Scholar : PubMed/NCBI

27. 

Hoffmann TK, Sonkoly E, Hauser U, van Lierop A, Whiteside TL, Klussmann JP, Hafner D, Schuler P, Friebe-Hoffmann U, Scheckenbach K, et al: Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma. Oral Oncol. 44:1100–1109. 2008. View Article : Google Scholar : PubMed/NCBI

28. 

Hoa M, Davis SL, Ames SJ and Spanjaard RA: Amplification of wild-type K -ras promotes growth of head and neck squamous. Cancer Res. 62:7154–7156. 2002.PubMed/NCBI

29. 

Blagoev KB: Cell proliferation in the presence of telomerase. PLoS One. 4:e46222009. View Article : Google Scholar : PubMed/NCBI

30. 

Ohira T, Naohiro S, Nakayama Y, Osaki M, Okada F, Oshimura M and Kugoh H: miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells. Sci Rep. 5:82012015. View Article : Google Scholar : PubMed/NCBI

31. 

Ueda Y, Hiyama E, Kamimatsuse A, Kamei N, Ogura K and Sueda T: Wnt signaling and telomerase activation of hepatoblastoma: Correlation with chemosensitivity and surgical resectability. J Pediatr Surg. 46:2221–2227. 2011. View Article : Google Scholar : PubMed/NCBI

32. 

Wang L, Li PF, Geng M, Cao YC and Yin YC: Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer. Diagn Pathol. 8:332013. View Article : Google Scholar : PubMed/NCBI

33. 

Guo X, Wang W, Zhou F, Lu Z, Fang R, Jia F, Bu X, Li R, Zhang B, Wu M and Wei L: siRNA-mediated inhibition of hTERT enhances chemosensitivity of hepatocellular carcinoma. Cancer Biol Ther. 7:1555–1560. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Takenobu M, Osaki M, Fujiwara K, Fukuhara T, Kitano H, Kugoh H and Okada F: PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma. Mol Clin Oncol 5: 89-94, 2016.
APA
Takenobu, M., Osaki, M., Fujiwara, K., Fukuhara, T., Kitano, H., Kugoh, H., & Okada, F. (2016). PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma. Molecular and Clinical Oncology, 5, 89-94. https://doi.org/10.3892/mco.2016.880
MLA
Takenobu, M., Osaki, M., Fujiwara, K., Fukuhara, T., Kitano, H., Kugoh, H., Okada, F."PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma". Molecular and Clinical Oncology 5.1 (2016): 89-94.
Chicago
Takenobu, M., Osaki, M., Fujiwara, K., Fukuhara, T., Kitano, H., Kugoh, H., Okada, F."PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma". Molecular and Clinical Oncology 5, no. 1 (2016): 89-94. https://doi.org/10.3892/mco.2016.880
Copy and paste a formatted citation
x
Spandidos Publications style
Takenobu M, Osaki M, Fujiwara K, Fukuhara T, Kitano H, Kugoh H and Okada F: PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma. Mol Clin Oncol 5: 89-94, 2016.
APA
Takenobu, M., Osaki, M., Fujiwara, K., Fukuhara, T., Kitano, H., Kugoh, H., & Okada, F. (2016). PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma. Molecular and Clinical Oncology, 5, 89-94. https://doi.org/10.3892/mco.2016.880
MLA
Takenobu, M., Osaki, M., Fujiwara, K., Fukuhara, T., Kitano, H., Kugoh, H., Okada, F."PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma". Molecular and Clinical Oncology 5.1 (2016): 89-94.
Chicago
Takenobu, M., Osaki, M., Fujiwara, K., Fukuhara, T., Kitano, H., Kugoh, H., Okada, F."PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma". Molecular and Clinical Oncology 5, no. 1 (2016): 89-94. https://doi.org/10.3892/mco.2016.880
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team