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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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August-2016 Volume 5 Issue 2

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Review

Association of MSH6 mutation with glioma susceptibility, drug resistance and progression (Review)

  • Authors:
    • Chaoran Xie
    • Hansong Sheng
    • Nu Zhang
    • Shiting Li
    • Xiangyu Wei
    • Xuesheng Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. China, Department of Neurosurgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China
  • Pages: 236-240
    |
    Published online on: May 20, 2016
       https://doi.org/10.3892/mco.2016.907
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Abstract

MutS homolog 6 (MSH6) is one of the mismatch repair proteins and is encoded by the MSH6 gene, which is located on chromosome 2 and is 23,806 bp in length, including 10 exons and 83 untranslated regions. The MSH6 protein consists of 1,358 amino acid residues and forms a heterodimer with another mismatch repair protein, MSH2. The MSH2‑MSH6 heterodimeric complex is able to recognize base‑base substitution and single-base insertion/deletion mismatches. Germline mutations of MSH6 lead to high susceptibility to glioma, as well as a number of benign or malignant tumors in other organs. However, somatic MSH6 mutations are not associated with susceptibility to glioma. Somatic MSH6 mutations usually follow temozolomide treatment and result in resistance to temozolomide. Subsequently, MSH6 mutations cause a hypermutation in the glioma cell genome, which may accelerate tumor progression.
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Copy and paste a formatted citation
Spandidos Publications style
Xie C, Sheng H, Zhang N, Li S, Wei X and Zheng X: Association of MSH6 mutation with glioma susceptibility, drug resistance and progression (Review). Mol Clin Oncol 5: 236-240, 2016.
APA
Xie, C., Sheng, H., Zhang, N., Li, S., Wei, X., & Zheng, X. (2016). Association of MSH6 mutation with glioma susceptibility, drug resistance and progression (Review). Molecular and Clinical Oncology, 5, 236-240. https://doi.org/10.3892/mco.2016.907
MLA
Xie, C., Sheng, H., Zhang, N., Li, S., Wei, X., Zheng, X."Association of MSH6 mutation with glioma susceptibility, drug resistance and progression (Review)". Molecular and Clinical Oncology 5.2 (2016): 236-240.
Chicago
Xie, C., Sheng, H., Zhang, N., Li, S., Wei, X., Zheng, X."Association of MSH6 mutation with glioma susceptibility, drug resistance and progression (Review)". Molecular and Clinical Oncology 5, no. 2 (2016): 236-240. https://doi.org/10.3892/mco.2016.907
Copy and paste a formatted citation
x
Spandidos Publications style
Xie C, Sheng H, Zhang N, Li S, Wei X and Zheng X: Association of MSH6 mutation with glioma susceptibility, drug resistance and progression (Review). Mol Clin Oncol 5: 236-240, 2016.
APA
Xie, C., Sheng, H., Zhang, N., Li, S., Wei, X., & Zheng, X. (2016). Association of MSH6 mutation with glioma susceptibility, drug resistance and progression (Review). Molecular and Clinical Oncology, 5, 236-240. https://doi.org/10.3892/mco.2016.907
MLA
Xie, C., Sheng, H., Zhang, N., Li, S., Wei, X., Zheng, X."Association of MSH6 mutation with glioma susceptibility, drug resistance and progression (Review)". Molecular and Clinical Oncology 5.2 (2016): 236-240.
Chicago
Xie, C., Sheng, H., Zhang, N., Li, S., Wei, X., Zheng, X."Association of MSH6 mutation with glioma susceptibility, drug resistance and progression (Review)". Molecular and Clinical Oncology 5, no. 2 (2016): 236-240. https://doi.org/10.3892/mco.2016.907
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