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Article

MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm

  • Authors:
    • Tatsuo Shimura
    • Yasuhide Kofunato
    • Ryo Okada
    • Rei Yashima
    • Koji Okada
    • Kenichiro Araki
    • Yasuo Hosouchi
    • Hiroyuki Kuwano
    • Seiichi Takenoshita
  • View Affiliations / Copyright

    Affiliations: Department of Cancer Biology and Electronics, Fukushima Medical University, Fukushima 960‑1295, Japan, Department of Organ Regulatory Surgery, Fukushima Medical University, Fukushima 960‑1295, Japan, Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma 371‑8511, Japan, Department of Surgery and Laparoscopic Surgery, Gunma Prefecture Saiseikai‑Maebashi Hospital, Maebashi, Gunma 371‑0821, Japan
  • Pages: 317-322
    |
    Published online on: May 20, 2016
       https://doi.org/10.3892/mco.2016.908
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Abstract

Despite strict criteria for the observation of intraductal papillary mucinous neoplasm (IPMN), it remains difficult to distinguish invasive IPMN from non-invasive IPMN. The aim of the present study was to identify an indicator of invasive IPMN. The present study retrospectively evaluated 53 patients (28 with non‑invasive and 25 with invasive IPMN) who underwent resection of IPMN, and examined the usefulness of the MIB‑1 labeling index as an indicator of invasive IPMN. The MIB‑1 labeling indexes in patients with invasive IPMN were significantly higher compared with those with non‑invasive IPMN (P<0.001). A receiver operating characteristic curve revealed that the area under the curve was 0.822. These results suggested that a cut‑off level for the MIB‑1 labeling index should be set to 15.5% to distinguish invasive from non‑invasive IPMN. A multivariate analysis using a logistic regression model revealed the MIB‑1 labeling index (hazard ratio, 18.692; 95% confidential interval, 4.171‑83.760; P<0.001) and the existence of mural nodules (hazard ratio, 6.187, 95% confidential interval, 1.039‑36.861; P=0.045) were predictive factors for invasive IPMN. However, no statistically significant differences were observed between patients with a lower MIB-1 labeling index and patients with a higher MIB‑1 labeling index (P=0.798). The MIB-1 labeling index must be considered as a candidate for the classification of IPMN.
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Copy and paste a formatted citation
Spandidos Publications style
Shimura T, Kofunato Y, Okada R, Yashima R, Okada K, Araki K, Hosouchi Y, Kuwano H and Takenoshita S: MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm. Mol Clin Oncol 5: 317-322, 2016.
APA
Shimura, T., Kofunato, Y., Okada, R., Yashima, R., Okada, K., Araki, K. ... Takenoshita, S. (2016). MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm. Molecular and Clinical Oncology, 5, 317-322. https://doi.org/10.3892/mco.2016.908
MLA
Shimura, T., Kofunato, Y., Okada, R., Yashima, R., Okada, K., Araki, K., Hosouchi, Y., Kuwano, H., Takenoshita, S."MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm". Molecular and Clinical Oncology 5.2 (2016): 317-322.
Chicago
Shimura, T., Kofunato, Y., Okada, R., Yashima, R., Okada, K., Araki, K., Hosouchi, Y., Kuwano, H., Takenoshita, S."MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm". Molecular and Clinical Oncology 5, no. 2 (2016): 317-322. https://doi.org/10.3892/mco.2016.908
Copy and paste a formatted citation
x
Spandidos Publications style
Shimura T, Kofunato Y, Okada R, Yashima R, Okada K, Araki K, Hosouchi Y, Kuwano H and Takenoshita S: MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm. Mol Clin Oncol 5: 317-322, 2016.
APA
Shimura, T., Kofunato, Y., Okada, R., Yashima, R., Okada, K., Araki, K. ... Takenoshita, S. (2016). MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm. Molecular and Clinical Oncology, 5, 317-322. https://doi.org/10.3892/mco.2016.908
MLA
Shimura, T., Kofunato, Y., Okada, R., Yashima, R., Okada, K., Araki, K., Hosouchi, Y., Kuwano, H., Takenoshita, S."MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm". Molecular and Clinical Oncology 5.2 (2016): 317-322.
Chicago
Shimura, T., Kofunato, Y., Okada, R., Yashima, R., Okada, K., Araki, K., Hosouchi, Y., Kuwano, H., Takenoshita, S."MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm". Molecular and Clinical Oncology 5, no. 2 (2016): 317-322. https://doi.org/10.3892/mco.2016.908
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