A spindle cell anaplastic pancreatic carcinoma with rhabdoid features following curative resection

Abe,Tomoyuki; Amano,Hironobu; Hanada,Keiji; Okazaki,Akihisa; Yonehara,Shuji; Kuranishi,Fumito; Nakahara,Masahiro; Kuroda,Yoshinori; Noriyuki,Toshio

doi:10.3892/mco.2016.914

August-2016 Volume 5 Issue 2

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August-2016 Volume 5 Issue 2

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Article

A spindle cell anaplastic pancreatic carcinoma with rhabdoid features following curative resection

Authors:
- Tomoyuki Abe
- Hironobu Amano
- Keiji Hanada
- Akihisa Okazaki
- Shuji Yonehara
- Fumito Kuranishi
- Masahiro Nakahara
- Yoshinori Kuroda
- Toshio Noriyuki
View Affiliations / Copyright

Affiliations: Department of Surgery, Onomichi General Hospital, Onomichi, Hiroshima 722-8508, Japan, Department of Gastroenterology, Onomichi General Hospital, Onomichi, Hiroshima 722-8508, Japan, Department of Pathology, Onomichi General Hospital, Onomichi, Hiroshima 722-8508, Japan, Department of Surgery, Innoshima‑Ishikai Hospital, Innoshima, Hiroshima 1722‑2323, Japan
Pages: 327-330
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Published online on: May 30, 2016

https://doi.org/10.3892/mco.2016.914
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Abstract

Anaplastic pancreatic carcinoma (ANPC) accounts for ~5% of all pancreatic ductal adenocarcinoma cases. Due to its rarity, its clinical features and surgical outcomes remain to be clearly understood. A 74‑year‑old woman was admitted to Onomichi General Hospital (Onomichi, Japan) in April 2015 without any significant past medical history. Contrast‑enhanced computed tomography (CT) revealed a 9.5x8.0 cm tumor in the body and tail of the pancreas. The patient developed acute abdominal pain 3 weeks later and the CT revealed massive abdominal bleeding caused by tumor rupture. The tumor increased in size and reached 12.0x10.0 cm in maximal diameter. The tumor doubling time was estimated to be 13 days. 18F‑fluorodeoxyglucose (FDG) positron emission tomography/CT confirmed the absence of distant metastasis since FDG accumulation was detected only in the tumor lesion. Emergency distal pancreatectomy and splenectomy were performed. Histologically, the tumor was classified as a spindle cell ANPC with rhabdoid features. The patient succumbed to mortality 8 months following the surgery while undergoing systemic adjuvant chemotherapy for multiple liver metastases. ANPC is difficult to detect in the early stages due to its progressive nature and atypical radiological findings. Long‑term survival can be achieved only by curative resection; therefore, surgical resection must be performed whenever possible, even if the chance of long‑term survival following surgery is considered dismal. As the present case suggested, spindle cell ANPC with rhabdoid features is highly aggressive and curative‑intent resection must not be delayed.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A spindle cell anaplastic pancreatic carcinoma with rhabdoid features following curative resection

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