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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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August-2016 Volume 5 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study

  • Authors:
    • Umut Riza Gündüz
    • Meral Gunaldi
    • Nilgun Isiksacan
    • Seyda Gündüz
    • Yildiz Okuturlar
    • Hakan Kocoglu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Antalya Education and Research Hospital, Antalya 07100, Turkey, Department of Medical Oncology, Bakırköy Education and Research Hospital, Istanbul 07100, Turkey, Department of Biochemistry, Bakırköy Education and Research Hospital, Istanbul 07100, Turkey, Department of Medical Oncology, Antalya Education and Research Hospital, Antalya 07100, Turkey, Department of Internal Medicine, Bakırköy Education and Research Hospital, Istanbul 34147, Turkey
  • Pages: 355-360
    |
    Published online on: June 3, 2016
       https://doi.org/10.3892/mco.2016.919
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Abstract

Breast cancer is the most frequently diagnosed cancer type in women. Tumor markers have been widely used for assessing the treatment response and early diagnosis of recurrence. Human epididymis protein 4 (HE4) is expressed in ductal carcinoma of the breast tissue; however, its serum levels and their diagnostic and prognostic potential in breast cancer have not been investigated, which was therefore the aim of the present study. The serum levels of HE4 were determined in 36 breast cancer patients, 11 ovarian cancer patients and 16 healthy volunteers. The association between clinicopathological characteristics of breast cancer and serum HE4 levels was investigated. A significant difference in the median serum levels of HE4 was identified between breast cancer patients, ovarian cancer patients and healthy volunteers (P=0.013). The cutoff value for the prediction of breast cancer was determined at >13.24 pmol/l for HE4, with a sensitivity of 61.11%, specificity of 68.75%, positive predictive value of 81.48%, negative predictive value of 44.0% and accuracy of 63.46%. Furthermore, a positive correlation between the serum levels of HE4 and cancer antigen 15-3 was determined (r=0.399, P=0.026). To the best of our knowledge, the present study was the first to determine the diagnostic value of serum HE4 for breast cancer. A significant elevation of serum HE4 levels in patients with breast cancer compared with that in healthy controls was identified. HE4 may serve as a novel biomarker for the diagnosis of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Gündüz UR, Gunaldi M, Isiksacan N, Gündüz S, Okuturlar Y and Kocoglu H: A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study. Mol Clin Oncol 5: 355-360, 2016.
APA
Gündüz, U.R., Gunaldi, M., Isiksacan, N., Gündüz, S., Okuturlar, Y., & Kocoglu, H. (2016). A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study. Molecular and Clinical Oncology, 5, 355-360. https://doi.org/10.3892/mco.2016.919
MLA
Gündüz, U. R., Gunaldi, M., Isiksacan, N., Gündüz, S., Okuturlar, Y., Kocoglu, H."A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study". Molecular and Clinical Oncology 5.2 (2016): 355-360.
Chicago
Gündüz, U. R., Gunaldi, M., Isiksacan, N., Gündüz, S., Okuturlar, Y., Kocoglu, H."A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study". Molecular and Clinical Oncology 5, no. 2 (2016): 355-360. https://doi.org/10.3892/mco.2016.919
Copy and paste a formatted citation
x
Spandidos Publications style
Gündüz UR, Gunaldi M, Isiksacan N, Gündüz S, Okuturlar Y and Kocoglu H: A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study. Mol Clin Oncol 5: 355-360, 2016.
APA
Gündüz, U.R., Gunaldi, M., Isiksacan, N., Gündüz, S., Okuturlar, Y., & Kocoglu, H. (2016). A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study. Molecular and Clinical Oncology, 5, 355-360. https://doi.org/10.3892/mco.2016.919
MLA
Gündüz, U. R., Gunaldi, M., Isiksacan, N., Gündüz, S., Okuturlar, Y., Kocoglu, H."A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study". Molecular and Clinical Oncology 5.2 (2016): 355-360.
Chicago
Gündüz, U. R., Gunaldi, M., Isiksacan, N., Gündüz, S., Okuturlar, Y., Kocoglu, H."A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study". Molecular and Clinical Oncology 5, no. 2 (2016): 355-360. https://doi.org/10.3892/mco.2016.919
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