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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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August-2016 Volume 5 Issue 2

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Case Report

Sorafenib and a novel immune therapy in lung metastasis from hepatocellular carcinoma following hepatectomy: A case report

  • Authors:
    • Yongxiang Yi
    • Jianbo Han
    • Yuan Fang
    • Dongxiao Liu
    • Zuoyou Wu
    • Lili Wang
    • Liang Zhao
    • Qiang Wei
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210003, P.R. China, Department of Pathology, The Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210003, P.R. China, Biological Treatment Center, The Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210003, P.R. China, Department of Ultrasonography, The Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210003, P.R. China
  • Pages: 337-341
    |
    Published online on: June 10, 2016
       https://doi.org/10.3892/mco.2016.925
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Abstract

Sorafenib is the standard therapeutic strategy for recurrent hepatocellular carcinoma (HCC) following hepatectomy. However, only few patients truly benefit from this therapy. Thus, new strategies combined with sorafenib are urgently required. We herein present the case of a patient with hepatic and extrahepatic HCC recurrence following hepatectomy, who was treated by combined sorafenib, focused ultrasound knife and DRibbles‑pulsed dendritic cell (DC) vaccine. Enzyme-Linked ImmunoSpot assay (ELISPOT) and intracellular staining (ICS) analysis were used to detect the secretion of interferon (IFN)‑γ by T cells at different timepoints of the vaccine in order to evaluate the patient's specific T‑cell response to SMMC‑7721‑derived DRibbles vaccine. The α‑fetoprotein level decreased from 103,295 to 5 ng̸ml and the patient displayed improved liver function, an Eastern Cooperative Oncology Group performance status score of 0, remission of liver metastases and disappearance of the lung metastases 8 months post‑combination therapy. The computed tomography scan revealed the disappearance of liver metastases 2 years post‑combination therapy. The ELISPOT data revealed a low antigen‑specific T‑cell response 4 weeks after the first vaccine cycle and the response decreased to nearly zero prior to the second cycle. However, high antigen‑specific T‑cell response was observed 2 weeks after the second vaccine cycle and did not decrease, even after 10 months, which was consistent with the result of the ICS analysis, which demonstrated that most of the secreted IFN‑γ was produced by CD4+ T cells, whereas a low CD8+ T‑cell response was observed (0.429 vs. 0.0665%, respectively). Our results demonstrated that antigen‑specific T‑cell response aimed to treat recurrent HCC may be induced through stimulation by the DC‑DRibbles vaccine. The success of the treatment supports the combination of sorafenib, focused ultrasound knife and DC‑DRibbles vaccine as a therapeutic strategy for patients with HCC recurrence following hepatectomy.
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Copy and paste a formatted citation
Spandidos Publications style
Yi Y, Han J, Fang Y, Liu D, Wu Z, Wang L, Zhao L and Wei Q: Sorafenib and a novel immune therapy in lung metastasis from hepatocellular carcinoma following hepatectomy: A case report. Mol Clin Oncol 5: 337-341, 2016.
APA
Yi, Y., Han, J., Fang, Y., Liu, D., Wu, Z., Wang, L. ... Wei, Q. (2016). Sorafenib and a novel immune therapy in lung metastasis from hepatocellular carcinoma following hepatectomy: A case report. Molecular and Clinical Oncology, 5, 337-341. https://doi.org/10.3892/mco.2016.925
MLA
Yi, Y., Han, J., Fang, Y., Liu, D., Wu, Z., Wang, L., Zhao, L., Wei, Q."Sorafenib and a novel immune therapy in lung metastasis from hepatocellular carcinoma following hepatectomy: A case report". Molecular and Clinical Oncology 5.2 (2016): 337-341.
Chicago
Yi, Y., Han, J., Fang, Y., Liu, D., Wu, Z., Wang, L., Zhao, L., Wei, Q."Sorafenib and a novel immune therapy in lung metastasis from hepatocellular carcinoma following hepatectomy: A case report". Molecular and Clinical Oncology 5, no. 2 (2016): 337-341. https://doi.org/10.3892/mco.2016.925
Copy and paste a formatted citation
x
Spandidos Publications style
Yi Y, Han J, Fang Y, Liu D, Wu Z, Wang L, Zhao L and Wei Q: Sorafenib and a novel immune therapy in lung metastasis from hepatocellular carcinoma following hepatectomy: A case report. Mol Clin Oncol 5: 337-341, 2016.
APA
Yi, Y., Han, J., Fang, Y., Liu, D., Wu, Z., Wang, L. ... Wei, Q. (2016). Sorafenib and a novel immune therapy in lung metastasis from hepatocellular carcinoma following hepatectomy: A case report. Molecular and Clinical Oncology, 5, 337-341. https://doi.org/10.3892/mco.2016.925
MLA
Yi, Y., Han, J., Fang, Y., Liu, D., Wu, Z., Wang, L., Zhao, L., Wei, Q."Sorafenib and a novel immune therapy in lung metastasis from hepatocellular carcinoma following hepatectomy: A case report". Molecular and Clinical Oncology 5.2 (2016): 337-341.
Chicago
Yi, Y., Han, J., Fang, Y., Liu, D., Wu, Z., Wang, L., Zhao, L., Wei, Q."Sorafenib and a novel immune therapy in lung metastasis from hepatocellular carcinoma following hepatectomy: A case report". Molecular and Clinical Oncology 5, no. 2 (2016): 337-341. https://doi.org/10.3892/mco.2016.925
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