T-cell acute lymphoblastic leukemia with co-expression of CD56, CD34, CD117 and CD33: A case with poor prognosis

Eren,Rafet; Aslan,Ceyda; Yokuş,Osman; Doğu,Mehmet  Hilmi; Suyani,Elif

doi:10.3892/mco.2016.927

August-2016 Volume 5 Issue 2

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August-2016 Volume 5 Issue 2

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Article

T-cell acute lymphoblastic leukemia with co-expression of CD56, CD34, CD117 and CD33: A case with poor prognosis

Authors:
- Rafet Eren
- Ceyda Aslan
- Osman Yokuş
- Mehmet Hilmi Doğu
- Elif Suyani
View Affiliations / Copyright

Affiliations: Department of Hematology, Istanbul Training and Research Hospital, Fatih, 34098 Istanbul, Turkey
Pages: 331-332
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Published online on: June 13, 2016

https://doi.org/10.3892/mco.2016.927
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Abstract

T-cell acute lymphoblastic leukemia (ALL) is an aggressive hematological malignancy, accounting for ~25% of all adult cases of ALL. We herein report a case of T-cell ALL exhibiting aberrant CD34, CD56, CD33 and CD117 expression in addition to T‑cell markers, which did not respond to induction treatment. A 55‑year‑old woman was admitted to our hospital with a sore throat unresponsive to medication for 1 month. The laboratory examination revealed pancytopenia and the peripheral blood smear examination revealed blast cells. On flow cytometric analysis, the blast cells were found to be positive for cytoplasmic CD3, CD2, CD5, CD7, CD34, CD56, CD33 and CD117, and negative for myeloperoxidase, CD13, CD11b, CD15, CD19, CD79a, CD22 and CD10. The patient was diagnosed with T‑cell ALL according to the 2008 World Health Organisation classification. The patient did not respond to Hyper‑cyclophosphamide, vincristine, adriamycin and dexamethasone (CVAD) course A treatment and succumbed to the disease during Hyper‑CVAD course B treatment. To the best of our knowledge, this is the first report of aberrant co‑expression of the natural killer cell marker CD56, myeloid cell markers CD117 and CD33 and stem cell marker CD34 in a patient with T‑cell ALL. This appears to be associated with an unfavorable outcome, despite the use of intensive chemotherapy.

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1	Van Vlierberghe P and Ferrando A: The molecular basis of T-cell acute lymphoblastic leukemia. J Clin Invest. 122:3398–3406. 2012. View Article : Google Scholar : PubMed/NCBI
2	Gamal AH: Classification of Acute Leukemia. University of Aden/Hematology unit. Yemen: 2011.
3	Supriyadi E, Veerman AJ Sutaryo, Purwanto I, Vd Ven PM and Cloos J: Myeloid antigen expression in childhood acute lymphoblastic leukemia and its relevance for clinical outcome in indonesian ALL-2006 protocol. J Oncol. 2012:1351862012. View Article : Google Scholar : PubMed/NCBI
4	Suggs JL, Cruse JM and Lewis RE: Aberrant myeloid marker expression in precursor B-cell and T-cell leukemias. Exp Mol Pathol. 83:471–473. 2007. View Article : Google Scholar : PubMed/NCBI
5	Uckun FM, Sather HN, Gaynon PS, Arthur DC, Trigg ME, Tubergen DG, Nachman J, Steinherz PG, Sensel MG and Reaman GH: Clinical features and treatment outcome of children with myeloid antigen-positive acute lymphoblastic leukemia: A report from the Children's cancer group. Blood. 90:28–35. 1997.PubMed/NCBI
6	Montero I, Rios E, Parody R, Perez-Hurtado JM, Martin-Noya A and Rodriguez JM: CD56 in T-cell acute lymphoblastic leukaemia: A malignant transformation of an early myeloid-lymphoid progenitor? Haematologica. 88:ELT262003.PubMed/NCBI
7	Fischer L, Gökbuget N, Schwartz S, Burmeister T, Rieder H, Brüggemann M, Hoelzer D and Thiel E: CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy. Haematologica. 94:224–229. 2009. View Article : Google Scholar : PubMed/NCBI
8	Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellström-Lindberg E, Tefferi A and Bloomfield CD: The 2008 revision of the world health organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes. Blood. 114:937–951. 2009. View Article : Google Scholar : PubMed/NCBI
9	Pui CH, Hancock ML, Head DR, Rivera GK, Look AT, Sandlund JT and Behm FG: Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia. Blood. 82:889–894. 1993.PubMed/NCBI
10	Vitale A, Guarini A, Ariola C, Mancini M, Mecucci C, Cuneo A, Pane F, Saglio G, Cimino G, Tafuri A, et al: Adult T-cell acute lymphoblastic leukemia: Biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol. Blood. 107:473–479. 2006. View Article : Google Scholar : PubMed/NCBI
11	Bhushan B, Chauhan PS, Saluja S, Verma S, Mishra AK, Siddiqui S and Kapur S: Aberrant phenotypes in childhood and adult acute leukemia and its association with adverse prognostic factors and clinical outcome. Clin Exp Med. 10:33–40. 2010. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

T-cell acute lymphoblastic leukemia with co-expression of CD56, CD34, CD117 and CD33: A case with poor prognosis

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