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Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis

  • Authors:
    • Tomofumi Naruse
    • Souichi Yanamoto
    • Yuki Matsushita
    • Yuki Sakamoto
    • Kota Morishita
    • Seigo Ohba
    • Takeshi Shiraishi
    • Shin‑Ichi Yamada
    • Izumi Asahina
    • Masahiro Umeda
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oral Oncology, Graduate School of Biomedical Sciences, Nagasaki University Hospital, Nagasaki, Nagasaki 852‑8588, Japan, Department of Regenerative Oral Surgery, Graduate School of Biomedical Sciences, Nagasaki University Hospital, Nagasaki, Nagasaki 852‑8588, Japan, Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Nagano 390‑8621, Japan
    Copyright: © Naruse et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 246-252
    |
    Published online on: June 13, 2016
       https://doi.org/10.3892/mco.2016.928
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Abstract

The aim of this retrospective study was to assess the efficacy and safety of cetuximab therapy for patients with locally advanced (LA) and recurrent̸metastatic (R̸M) oral squamous cell carcinoma (OSCC), with a specific focus on distant metastases (DMs). Data from 21 patients with unresectable LA and R̸M OSCC treated with cetuximab therapy in our department between December, 2012 and July, 2015 were reviewed. The endpoint was the time‑to‑progression and the assessments made were tumor response rate, progression‑free survival (PFS), overall survival (OS) and safety. The overall response rate was 57.1%, with a complete response (CR) rate of 33.3%. The overall median PFS and OS were 5.5 and 8.0 months, respectively. For patients with DMs, the overall response rate was 60.0%, with a CR rate of 40.0%. The median PFS and OS were 3.8 and 5.8 months, respectively. In addition, improved 1‑year OS was observed following approval of cetuximab, although the differences between the group of patients treated after that time and historical controls were not statistically significantly (P=0.246). Grade 3‑4 adverse events included infusion reaction (4 cases), neutropenia, hypophosphatemia, upper gastrointestinal hemorrhage, liver toxicity and mucositis (1 case each). There was one cetuximab‑related death due to interstitial pneumonia. An acne‑like rash was observed in all cases, but no grade 3 or 4 rash was reported. Hypomagnesemia was observed in 10 cases. Our results suggest that cetuximab may display significant therapeutic efficacy in patients with unresectable LA and R̸M OSCC, including those with DMs.
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Copy and paste a formatted citation
Spandidos Publications style
Naruse T, Yanamoto S, Matsushita Y, Sakamoto Y, Morishita K, Ohba S, Shiraishi T, Yamada SI, Asahina I, Umeda M, Umeda M, et al: Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis. Mol Clin Oncol 5: 246-252, 2016.
APA
Naruse, T., Yanamoto, S., Matsushita, Y., Sakamoto, Y., Morishita, K., Ohba, S. ... Umeda, M. (2016). Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis. Molecular and Clinical Oncology, 5, 246-252. https://doi.org/10.3892/mco.2016.928
MLA
Naruse, T., Yanamoto, S., Matsushita, Y., Sakamoto, Y., Morishita, K., Ohba, S., Shiraishi, T., Yamada, S., Asahina, I., Umeda, M."Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis". Molecular and Clinical Oncology 5.2 (2016): 246-252.
Chicago
Naruse, T., Yanamoto, S., Matsushita, Y., Sakamoto, Y., Morishita, K., Ohba, S., Shiraishi, T., Yamada, S., Asahina, I., Umeda, M."Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis". Molecular and Clinical Oncology 5, no. 2 (2016): 246-252. https://doi.org/10.3892/mco.2016.928
Copy and paste a formatted citation
x
Spandidos Publications style
Naruse T, Yanamoto S, Matsushita Y, Sakamoto Y, Morishita K, Ohba S, Shiraishi T, Yamada SI, Asahina I, Umeda M, Umeda M, et al: Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis. Mol Clin Oncol 5: 246-252, 2016.
APA
Naruse, T., Yanamoto, S., Matsushita, Y., Sakamoto, Y., Morishita, K., Ohba, S. ... Umeda, M. (2016). Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis. Molecular and Clinical Oncology, 5, 246-252. https://doi.org/10.3892/mco.2016.928
MLA
Naruse, T., Yanamoto, S., Matsushita, Y., Sakamoto, Y., Morishita, K., Ohba, S., Shiraishi, T., Yamada, S., Asahina, I., Umeda, M."Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis". Molecular and Clinical Oncology 5.2 (2016): 246-252.
Chicago
Naruse, T., Yanamoto, S., Matsushita, Y., Sakamoto, Y., Morishita, K., Ohba, S., Shiraishi, T., Yamada, S., Asahina, I., Umeda, M."Cetuximab for the treatment of locally advanced and recurrent/metastatic oral cancer: An investigation of distant metastasis". Molecular and Clinical Oncology 5, no. 2 (2016): 246-252. https://doi.org/10.3892/mco.2016.928
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