Nephrogenic adenoma in elderly patients: Three case reports

Sakatani,Toru; Adachi,Yasushi; Sakaida,Noriko; Atsuta,Takeshi; Magaribuchi,Toshihiro; Taki,Yoji; Nakano,Yorika; Li,Ming; Ikehara,Susumu

doi:10.3892/mco.2016.930

August-2016 Volume 5 Issue 2

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August-2016 Volume 5 Issue 2

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Case Report

Nephrogenic adenoma in elderly patients: Three case reports

Authors:
- Toru Sakatani
- Yasushi Adachi
- Noriko Sakaida
- Takeshi Atsuta
- Toshihiro Magaribuchi
- Yoji Taki
- Yorika Nakano
- Ming Li
- Susumu Ikehara
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Affiliations: Department of Urology, Toyooka Hospital, Toyooka, Hyogo 668-8501, Japan, Department of Surgical Pathology, Toyooka Hospital, Toyooka, Hyogo 668-8501, Japan, Department of Diagnostic Pathology, Kakogawa West City Hospital, Kakogawa, Hyogo 675-8611, Japan, Department of Urology, Kurashiki Central Hospital, Kurashiki, Okayama 710‑8602, Japan, Department of Surgical Pathology, Kansai Medical University, Hirakata Hospital, Hirakata, Osaka 573-1191, Japan, Department of Stem Cell Disorders, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan
Pages: 253-256
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Published online on: June 13, 2016

https://doi.org/10.3892/mco.2016.930
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Abstract

Nephrogenic adenoma (NA), referred to as nephrogenic metaplasia, is a rare benign lesion of the urinary tract. NA is histologically characterized by tubular and papillary formations lined by low cuboidal to columnar epithelial cells. NA is also immunohistochemically characterized by positivity for paired box (PAX) 2, PAX8 and cytokeratin 7, and negative for p63 and prostate‑specific antigen. In this study, we present 3 cases of NA arising in the urinary bladder of elderly male patients with predisposing factors: patient 1 had undergone transurethral lithotripsy due to a ureteral stone; patient 2 had undergone transurethral resection of a urothelial carcinoma in the urinary bladder; and patient 3 had been treated with Bacillus‑Calmettle‑Guérin due to a urothelial carcinoma in the urinary bladder. The characteristics of the NAs of our 3 cases were histologically and immunohistologically consistent with previously reported cases, although 1 patient exhibited a pseudoinvasive pattern. Since NA is a tumor‑like benign lesion, it should be clearly differentiated morphologically and immunohistologically from other tumors arising in the urinary tract and from invasion by prostate cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Nephrogenic adenoma in elderly patients: Three case reports

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