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Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy

  • Authors:
    • Xiaofeng Zhou
    • Xiaofang Liao
    • Bicheng Zhang
    • Huijuan He
    • Yongjie Shui
    • Wenhong Xu
    • Chaogen Jiang
    • Li Shen
    • Qichun Wei
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Radiation Oncology, Quzhou Central Hospital, Quzhou, Zhejiang 324000, P.R. China, Department of Radiology, Quzhou Central Hospital, Quzhou, Zhejiang 324000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 289-294
    |
    Published online on: June 15, 2016
       https://doi.org/10.3892/mco.2016.936
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Abstract

There is currently no consensus regarding the optimal radiation volume for high‑grade glioma (HGG). The brain volume irradiated is associated with the extent of radiation neurotoxicity. When reducing the treatment volume, the risk of geographic tumor miss should be considered. In such cases, the recurrence patterns and, particularly, the rate of marginal tumor recurrence, are important indices for determining the optimal radiation volume. In the present study, a smaller‑target delineation protocol with limited margins was adopted. The postoperative enhancing tumor and resection cavity were defined as gross tumor volume (GTV); 1 and 2 cm were added to the GTV to create clinical target volume (CTV1 and CTV2), which received 60 and 54 Gy, respectively. At a median follow-up of 14 months, 54 HGG patients developed tumor recurrence. The median overall and progression-free survival were 14 and 10.5 months, respectively. A total of 34 patients developed central recurrence, 8 presented with in‑field recurrence, 2 developed marginal recurrence, 2 had distant recurrence and 11 patients developed cerebrospinal fluid dissemination, 2 of whom developed central recurrence, with 1 patient simultaneously developing marginal recurrence. Local recurrence (central and in‑field) was found to be the main recurrence pattern. As the rate of marginal recurrence was low (<5%), it appears that the smaller irradiated volume in the present study was appropriate. However, clinical trials investigating limited irradiation volume are required to validate our findings.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Liao X, Zhang B, He H, Shui Y, Xu W, Jiang C, Shen L and Wei Q: Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy. Mol Clin Oncol 5: 289-294, 2016.
APA
Zhou, X., Liao, X., Zhang, B., He, H., Shui, Y., Xu, W. ... Wei, Q. (2016). Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy. Molecular and Clinical Oncology, 5, 289-294. https://doi.org/10.3892/mco.2016.936
MLA
Zhou, X., Liao, X., Zhang, B., He, H., Shui, Y., Xu, W., Jiang, C., Shen, L., Wei, Q."Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy". Molecular and Clinical Oncology 5.2 (2016): 289-294.
Chicago
Zhou, X., Liao, X., Zhang, B., He, H., Shui, Y., Xu, W., Jiang, C., Shen, L., Wei, Q."Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy". Molecular and Clinical Oncology 5, no. 2 (2016): 289-294. https://doi.org/10.3892/mco.2016.936
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Liao X, Zhang B, He H, Shui Y, Xu W, Jiang C, Shen L and Wei Q: Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy. Mol Clin Oncol 5: 289-294, 2016.
APA
Zhou, X., Liao, X., Zhang, B., He, H., Shui, Y., Xu, W. ... Wei, Q. (2016). Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy. Molecular and Clinical Oncology, 5, 289-294. https://doi.org/10.3892/mco.2016.936
MLA
Zhou, X., Liao, X., Zhang, B., He, H., Shui, Y., Xu, W., Jiang, C., Shen, L., Wei, Q."Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy". Molecular and Clinical Oncology 5.2 (2016): 289-294.
Chicago
Zhou, X., Liao, X., Zhang, B., He, H., Shui, Y., Xu, W., Jiang, C., Shen, L., Wei, Q."Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy". Molecular and Clinical Oncology 5, no. 2 (2016): 289-294. https://doi.org/10.3892/mco.2016.936
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