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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Article

Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial

  • Authors:
    • Wen‑Xing Kang
    • Wentao Li
    • Shi‑Gao Huang
    • Yazhang Dang
    • Hongxiang Gao
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, 323 Hospital of Chinese People's Liberation Army, Shaanxi, Xi'an 710054, P.R. China, Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an 710061, P.R. China
  • Pages: 279-282
    |
    Published online on: June 30, 2016
       https://doi.org/10.3892/mco.2016.943
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Abstract

Head and neck malignant tumors have numerous locations of the disease. After patients receive radiotherapy, their nutritional status is very poor, thus the curative effect is unsatisfactory. The aims of the present study were to investigate and analyze the nutritional status of patients with head and neck cancer undergoing radiotherapy (RT) in order to provide positive nutrition intervention for assisting the radiotherapy effect. A total of 40 patients with head and neck cancer were selected using a method of subjective global assessment (SGA) to assess nutritional status, including calorie intake and energy expenditure. In a randomized, controlled study, 20 patients received intensive dietary counseling and nutritional therapy (G1) and 20 received regular dietary as controls (G0) preradiotherapy and postradiotherapy. The primary endpoint was calorie intake and energy expenditure. The secondary endpoint was SGA rating with nutritional therapy. At the end of RT, energy intake showed a net increase in G1 (1,691±301 kcal) compared with that in G0 (1,066±312 kcal) (P<0.05); energy expenditure increased in G1 (1,673±279 kcal) compared with G0 (1,490±298 kcal) (P<0.05). The prevalence of severe malnutrition following radiotherapy was significantly different between the two study groups (10 patients in G0 and 4 patients in G1; P<0.05). The number of the normal malnutrition patients postRT in G0 decreased from 4 to 2 and conversely, in G1 it increased from 3 to 6 (P<0.05). In conclusion, patients with head and neck cancer were most malnutritioned, which impacted on clinical outcome. Timely nutritional intervention can effectively prevent weight loss and muscle wasting. Additionally, it may improve quality of life by decreasing the frequency of severe malnutrition.
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1 

Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, et al: Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci USA. 111:15544–15549. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Oates J, Clark JR, Read J, Reeves N, Gao K and O'Brien CJ: Integration of prospective quality of life and nutritional assessment as routine components of multidisciplinary care of patients with head and neck cancer. ANZ J Surg. 78:34–41. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Munshi A, Pandey MB, Durga T, Pandey KC, Bahadur S and Mohanti BK: Weight loss during radiotherapy for head and neck malignancies: What factors impact it? Nutr Cancer. 47:136–140. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Ottery FD: Rethinking nutritional support of the cancer patient: The new field of nutritional oncology. Semin Oncol. 21:770–778. 1994.PubMed/NCBI

5 

Qureshi N, Kellie S, Darnley I, et al: Professional practice. Manual of Dietetic Practice (5th). (Oxford). Wiley Blackwel. 5–19. 2014.

6 

Langius JA, Zandbergen MC, Eerenstein SE, van Tulder MW, Leemans CR, Kramer MH and Weijs PJ: Effect of nutritional interventions on nutritional status, quality of life and mortality in patients with head and neck cancer receiving (chemo)radiotherapy: A systematic review. Clin Nutr. 32:671–678. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Salama JK, Haddad RI, Kies MS, Busse PM, Dong L, Brizel DM, Eisbruch A, Tishler RB, Trotti AM and Garden AS: Clinical practice guidance for radiotherapy planning after induction chemotherapy in locoregionally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 75:725–733. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Suzuki H, Asakawa A, Amitani H, Nakamura N and Inui A: Cancer cachexia-pathophysiology and management. J Gastroenterol. 48:574–594. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Lis CG, Gupta D, Lammersfeld CA, Markman M and Vashi PG: Role of nutritional status in predicting quality of life outcomes in cancer-a systematic review of the epidemiological literature. Nutr J. 11:272012. View Article : Google Scholar : PubMed/NCBI

10 

Wheelwright S, Darlington AS, Hopkinson JB, Fitzsimmons D, White A and Johnson CD: A systematic review of health-related quality of life instruments in patients with cancer cachexia. Support Care Cancer. 21:2625–2636. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Ries A, Trottenberg P, Elsner F, Stiel S, Haugen D, Kaasa S and Radbruch L: A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: An EPCRC cachexia guidelines project. Palliat Med. 26:294–304. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Lundholm K, Daneryd P, Bosaeus I, Körner U and Lindholm E: Palliative nutritional intervention in addition to cyclooxygenase and erythropoietin treatment for patients with malignant disease: Effects on survival, metabolism, and function. Cancer. 100:1967–1977. 2004. View Article : Google Scholar : PubMed/NCBI

13 

De Waele E, Mattens S, Honoré PM, Spapen H, De Grève J and Pen JJ: Nutrition therapy in cachectic cancer patients. The tight caloric control (TiCaCo) pilot trial. Appetite. 91:298–301. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Cady J: Nutritional support during radiotherapy for head and neck cancer: The role of prophylactic feeding tube placement. Clin J Oncol Nurs. 11:875–880. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Beaver ME, Matheny KE, Roberts DB and Myers JN: Predictors of weight loss during radiation therapy. Otolaryngol Head Neck Surg. 125:645–648. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Larsson M, Hedelin B and Athlin E: Lived experiences of eating problems for patients with head and neck cancer during radiotherapy. J Clin Nurs. 12:562–570. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Zogbaum AT, Fitz P and Duffy V: Tube feeding may improve adherence to radiation treatment schedule in head and neck cancer. Top Clin Nutr. 19:95–106. 2004. View Article : Google Scholar

18 

Sobin LH, Gospodarowicz MK and Wittekind C: International Union Against Cancer (UICC) TNM Classification of Malignant Tumors (7th). Wiley-Blackwell. Oxford: 2009.

19 

Ravasco P, Monteiro-Grillo I, Marques Vidal P and Camilo ME: impact of nutrition on outcome: A prospective randomized controlled trial in patients with head and neck cancer undergoing radiotherapy. Head Neck. 27:659–668. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Günay E, Kaymaz D, Selçuk NT, Ergün P, Sengül F and Demir N: Effect of nutritional status in individuals with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation. Respirology. 8:1217–1222. 2013. View Article : Google Scholar

21 

Zhang L, Lu Y and Fang Y: Nutritional status and related factors of patients with advanced gastrointestinal cancer. Br J Nutr. 111:1239–1244. 2014. View Article : Google Scholar : PubMed/NCBI

22 

van Bokhorst-de van der Schueren MA, Van Leeuwen PA, Sauerwein HP, Kuik DJ, Snow GB and Quak JJ: Assessment of malnutrition parameters in head and neck cancer patients and their relation to postoperative complications. Head Neck. 19:419–425. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Donaldson SS and Lenon RA: Alternation of nutritional status: Impact of chemotherapy and radiotherapy. Cancer. 43(Suppl 5): S2036–S2052. 1979. View Article : Google Scholar

24 

Tong H, Isenring E and Yates P: The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients. Support Care Cancer. 17:83–90. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Giacosa A, Frascio F, Sukkar SG and Roncella S: Food intake and body composition in cancer cachexia. Nutrition. 12(Suppi 1): S20–S23. 1996. View Article : Google Scholar : PubMed/NCBI

26 

Maciá E, Moran J, Santos J, Blanco M, Mahedero G and Salas J: Nutritional evaluation and dietetic care in cancer patients treated with radiotherapy: Prospective study. Nutrition. 7:205–209. 1990.

27 

Dawson ER, Morley SE, Robertson AG and Soutar DS: Increasing dietary supervision can reduce weight loss in oral cancer patients. Nutr Cancer. 41:70–74. 2001. View Article : Google Scholar : PubMed/NCBI

28 

McQuellon RP, Moose DB, Russell GB, Case LD, Greven K, Stevens M and Shaw EG: Supportive use of megestrol acetate (Megace) with head/neck and lung cancer patients receiving radiation therapy. Int J Radiat Oncol Biol Phys. 52:1180–1185. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kang WX, Li W, Huang SG, Dang Y and Gao H: Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial. Mol Clin Oncol 5: 279-282, 2016.
APA
Kang, W., Li, W., Huang, S., Dang, Y., & Gao, H. (2016). Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial. Molecular and Clinical Oncology, 5, 279-282. https://doi.org/10.3892/mco.2016.943
MLA
Kang, W., Li, W., Huang, S., Dang, Y., Gao, H."Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial". Molecular and Clinical Oncology 5.3 (2016): 279-282.
Chicago
Kang, W., Li, W., Huang, S., Dang, Y., Gao, H."Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial". Molecular and Clinical Oncology 5, no. 3 (2016): 279-282. https://doi.org/10.3892/mco.2016.943
Copy and paste a formatted citation
x
Spandidos Publications style
Kang WX, Li W, Huang SG, Dang Y and Gao H: Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial. Mol Clin Oncol 5: 279-282, 2016.
APA
Kang, W., Li, W., Huang, S., Dang, Y., & Gao, H. (2016). Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial. Molecular and Clinical Oncology, 5, 279-282. https://doi.org/10.3892/mco.2016.943
MLA
Kang, W., Li, W., Huang, S., Dang, Y., Gao, H."Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial". Molecular and Clinical Oncology 5.3 (2016): 279-282.
Chicago
Kang, W., Li, W., Huang, S., Dang, Y., Gao, H."Effects of nutritional intervention in head and neck cancer patients undergoing radiotherapy: A prospective randomized clinical trial". Molecular and Clinical Oncology 5, no. 3 (2016): 279-282. https://doi.org/10.3892/mco.2016.943
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