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Article

DNA methylation and leukemia susceptibility in China: Evidence from an updated meta‑analysis

  • Authors:
    • Danjie Jiang
    • Yirun Li
    • Qingxiao Hong
    • Yusheng Shen
    • Chunjing Xu
    • Yan Xu
    • Huangkai Zhu
    • Dongjun Dai
    • Guifang Ouyang
    • Shiwei Duan
  • View Affiliations / Copyright

    Affiliations: Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Department of Hematology, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. China
  • Pages: 193-207
    |
    Published online on: July 12, 2016
       https://doi.org/10.3892/mco.2016.959
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Abstract

Mounting evidence supports a role for DNA methylation in the pathogenesis of leukemia; however, there no overview of these results in the Chinese population. The present study performed a comprehensive meta‑analysis to establish candidate genes with an altered methylation status in Chinese leukemia patients. Eligible studies were identified through searching the National Center of Biotechnology Information PubMed and Wanfang databases. Studies were pooled and overall odds ratios with corresponding confidence intervals were calculated. A total of 4,325 leukemia patients and 2,010 controls from 94 studies on 53 genes were included in this meta‑analysis, and 47 genes were found to be aberrantly methylated in leukemia patients. A further subgroup meta‑analysis by leukemia subtype demonstrated that hypermethylation of 5 genes, namely cyclin‑dependent kinase (CDKN)2A, DNA-binding protein inhibitor‑4, CDKN2B, glioma pathogenesis-related protein 1 and p73, contributed to the risk of various subtypes of leukemia. In addition, a strong association between CDKN2A and leukemia was identified in Chinese (P<0.00001) but not in European patients. The aberrantly methylated genes identified in the present meta‑analysis may help elucidate the mechanisms underlying the development of leukemia in Chinese patients.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang D, Li Y, Hong Q, Shen Y, Xu C, Xu Y, Zhu H, Dai D, Ouyang G, Duan S, Duan S, et al: DNA methylation and leukemia susceptibility in China: Evidence from an updated meta‑analysis. Mol Clin Oncol 5: 193-207, 2016.
APA
Jiang, D., Li, Y., Hong, Q., Shen, Y., Xu, C., Xu, Y. ... Duan, S. (2016). DNA methylation and leukemia susceptibility in China: Evidence from an updated meta‑analysis. Molecular and Clinical Oncology, 5, 193-207. https://doi.org/10.3892/mco.2016.959
MLA
Jiang, D., Li, Y., Hong, Q., Shen, Y., Xu, C., Xu, Y., Zhu, H., Dai, D., Ouyang, G., Duan, S."DNA methylation and leukemia susceptibility in China: Evidence from an updated meta‑analysis". Molecular and Clinical Oncology 5.3 (2016): 193-207.
Chicago
Jiang, D., Li, Y., Hong, Q., Shen, Y., Xu, C., Xu, Y., Zhu, H., Dai, D., Ouyang, G., Duan, S."DNA methylation and leukemia susceptibility in China: Evidence from an updated meta‑analysis". Molecular and Clinical Oncology 5, no. 3 (2016): 193-207. https://doi.org/10.3892/mco.2016.959
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang D, Li Y, Hong Q, Shen Y, Xu C, Xu Y, Zhu H, Dai D, Ouyang G, Duan S, Duan S, et al: DNA methylation and leukemia susceptibility in China: Evidence from an updated meta‑analysis. Mol Clin Oncol 5: 193-207, 2016.
APA
Jiang, D., Li, Y., Hong, Q., Shen, Y., Xu, C., Xu, Y. ... Duan, S. (2016). DNA methylation and leukemia susceptibility in China: Evidence from an updated meta‑analysis. Molecular and Clinical Oncology, 5, 193-207. https://doi.org/10.3892/mco.2016.959
MLA
Jiang, D., Li, Y., Hong, Q., Shen, Y., Xu, C., Xu, Y., Zhu, H., Dai, D., Ouyang, G., Duan, S."DNA methylation and leukemia susceptibility in China: Evidence from an updated meta‑analysis". Molecular and Clinical Oncology 5.3 (2016): 193-207.
Chicago
Jiang, D., Li, Y., Hong, Q., Shen, Y., Xu, C., Xu, Y., Zhu, H., Dai, D., Ouyang, G., Duan, S."DNA methylation and leukemia susceptibility in China: Evidence from an updated meta‑analysis". Molecular and Clinical Oncology 5, no. 3 (2016): 193-207. https://doi.org/10.3892/mco.2016.959
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