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Article

Underweight status predicts a poor prognosis in elderly patients with colorectal cancer

  • Authors:
    • Manabu Kaneko
    • Shin Sasaki
    • Kosuke Ozaki
    • Kazuhiro Ishimaru
    • Emi Terai
    • Hiroshi Nakayama
    • Toshiyuki Watanabe
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Omori Red Cross Hospital, Tokyo 143‑8527, Japan
  • Pages: 289-294
    |
    Published online on: July 21, 2016
       https://doi.org/10.3892/mco.2016.964
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Abstract

The aim of the present study was to evaluate the effect of underweight status on the survival of elderly patients undergoing surgery for colorectal cancer (CRC). A total of 113 patients aged ≥75 years who underwent curative surgery for CRC were included. In addition to standard perioperative variables, body mass index (BMI) was assessed. The patients were categorized as underweight (BMI<18.5 kg/m2) or non‑underweight (BMI≥18.5 kg/m2). The 3‑year overall survival (OS) and cancer‑specific survival (CSS) were analyzed. Of the 113 patients, 24 (21%) were underweight. The two groups were well‑balanced regarding all factors evaluated. In the multivariate analysis, underweight status was an independent indicator of lower 3‑year OS [hazard ratio (HR)=2.65; 95% confidence interval (CI): 1.08‑6.50; P=0.033] and CSS (HR=3.51, 95% CI: 1.16‑10.60; P=0.025) rates. Compared with the non‑underweight group, the underweight group had significantly worse 3‑year OS (66.7 vs. 86.5%, respectively; P=0.017) and CSS (74.1 vs. 90.9%, respectively; P=0.025) rates. Therefore, underweight status was a significant risk factor for poor survival in elderly CRC patients. The development of effective nutritional interventions may improve the prognosis of such patients.
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Copy and paste a formatted citation
Spandidos Publications style
Kaneko M, Sasaki S, Ozaki K, Ishimaru K, Terai E, Nakayama H and Watanabe T: Underweight status predicts a poor prognosis in elderly patients with colorectal cancer. Mol Clin Oncol 5: 289-294, 2016.
APA
Kaneko, M., Sasaki, S., Ozaki, K., Ishimaru, K., Terai, E., Nakayama, H., & Watanabe, T. (2016). Underweight status predicts a poor prognosis in elderly patients with colorectal cancer. Molecular and Clinical Oncology, 5, 289-294. https://doi.org/10.3892/mco.2016.964
MLA
Kaneko, M., Sasaki, S., Ozaki, K., Ishimaru, K., Terai, E., Nakayama, H., Watanabe, T."Underweight status predicts a poor prognosis in elderly patients with colorectal cancer". Molecular and Clinical Oncology 5.3 (2016): 289-294.
Chicago
Kaneko, M., Sasaki, S., Ozaki, K., Ishimaru, K., Terai, E., Nakayama, H., Watanabe, T."Underweight status predicts a poor prognosis in elderly patients with colorectal cancer". Molecular and Clinical Oncology 5, no. 3 (2016): 289-294. https://doi.org/10.3892/mco.2016.964
Copy and paste a formatted citation
x
Spandidos Publications style
Kaneko M, Sasaki S, Ozaki K, Ishimaru K, Terai E, Nakayama H and Watanabe T: Underweight status predicts a poor prognosis in elderly patients with colorectal cancer. Mol Clin Oncol 5: 289-294, 2016.
APA
Kaneko, M., Sasaki, S., Ozaki, K., Ishimaru, K., Terai, E., Nakayama, H., & Watanabe, T. (2016). Underweight status predicts a poor prognosis in elderly patients with colorectal cancer. Molecular and Clinical Oncology, 5, 289-294. https://doi.org/10.3892/mco.2016.964
MLA
Kaneko, M., Sasaki, S., Ozaki, K., Ishimaru, K., Terai, E., Nakayama, H., Watanabe, T."Underweight status predicts a poor prognosis in elderly patients with colorectal cancer". Molecular and Clinical Oncology 5.3 (2016): 289-294.
Chicago
Kaneko, M., Sasaki, S., Ozaki, K., Ishimaru, K., Terai, E., Nakayama, H., Watanabe, T."Underweight status predicts a poor prognosis in elderly patients with colorectal cancer". Molecular and Clinical Oncology 5, no. 3 (2016): 289-294. https://doi.org/10.3892/mco.2016.964
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