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Article

Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature

  • Authors:
    • Hannah Headon
    • Abdul Kasem
    • Reham Almukbel
    • Kefah Mokbel
  • View Affiliations / Copyright

    Affiliations: The London Breast Institute, The Princess Grace Hospital, W1U 5NY London, UK
  • Pages: 429-436
    |
    Published online on: August 1, 2016
       https://doi.org/10.3892/mco.2016.971
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Abstract

In breast cancer with >4 positive axillary lymph nodes, it is common practice to deliver radiotherapy to the affected site following mastectomy. However, less is known regarding the benefits this may confer on women with 1‑3 positive lymph nodes. In this meta‑analysis, we aimed to assess whether post‑mastectomy radiotherapy (PMRT) was beneficial for such patients. A literature review was conducted using the PubMed and Ovid databases. Selected studies were analysed and data regarding overall survival (OS) and locoregional recurrence (LRR) rates were extracted. Statistical analysis was then conducted in order to develop a combined risk ratio (RR) for both OS and LRR in the setting of PMRT in women with breast cancer with 1‑3 positive lymph nodes. PMRT in women with 1‑3 positive lymph nodes significantly reduced the risk of LRR, with a RR of 0.3 [95% confidence interval (CI): 0.23‑0.38] and also showed a minor benefit in terms of OS (RR=1.03, 95% CI: 1.00‑1.07). Therefore, in breast cancer patients with 1‑3 positive lymph nodes, PMRT significantly reduced the risk of LRR and was associated with a minor OS benefit. Until the results of ongoing randomised controlled trials are published, PMRT should be recommended in this group of patients following a careful multidisciplinary discussion.
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Copy and paste a formatted citation
Spandidos Publications style
Headon H, Kasem A, Almukbel R and Mokbel K: Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature. Mol Clin Oncol 5: 429-436, 2016.
APA
Headon, H., Kasem, A., Almukbel, R., & Mokbel, K. (2016). Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature. Molecular and Clinical Oncology, 5, 429-436. https://doi.org/10.3892/mco.2016.971
MLA
Headon, H., Kasem, A., Almukbel, R., Mokbel, K."Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature". Molecular and Clinical Oncology 5.4 (2016): 429-436.
Chicago
Headon, H., Kasem, A., Almukbel, R., Mokbel, K."Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature". Molecular and Clinical Oncology 5, no. 4 (2016): 429-436. https://doi.org/10.3892/mco.2016.971
Copy and paste a formatted citation
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Spandidos Publications style
Headon H, Kasem A, Almukbel R and Mokbel K: Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature. Mol Clin Oncol 5: 429-436, 2016.
APA
Headon, H., Kasem, A., Almukbel, R., & Mokbel, K. (2016). Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature. Molecular and Clinical Oncology, 5, 429-436. https://doi.org/10.3892/mco.2016.971
MLA
Headon, H., Kasem, A., Almukbel, R., Mokbel, K."Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature". Molecular and Clinical Oncology 5.4 (2016): 429-436.
Chicago
Headon, H., Kasem, A., Almukbel, R., Mokbel, K."Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature". Molecular and Clinical Oncology 5, no. 4 (2016): 429-436. https://doi.org/10.3892/mco.2016.971
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