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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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October-2016 Volume 5 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Case Report

Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature

  • Authors:
    • Yanling Feng
    • Tiefeng Cao
    • Yin Wang
    • He Huang
    • Yujie Xie
    • Jihong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Sun Yat‑Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 411-416
    |
    Published online on: August 1, 2016
       https://doi.org/10.3892/mco.2016.972
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Abstract

The average age when cervical cancer is diagnosed is decreasing, resulting in a larger proportion of patients seeking fertility preservation. Therefore, a less radical approach that aims to preserve the potential for fertility during the treatment of cervical carcinoma is crucial. The present study reported a case of a patient with stage IB2 cervical cancer who exhibited pathological complete regression to neoadjuvant chemotherapy (NACT). This patient underwent deep cervical conization and laparoscopic lymphadenectomy to preserve her fertility. The patient gave birth at 29 weeks of gestation and exhibited no recurrent disease until May 2016 (72 months after surgery). This is the first, to the best of our knowledge, IB2 case treatment by NACT, followed by conization plus lymphadenectomy, producing favorable oncological and obstetrical outcome. The present study, together with data from a limited number of published articles, offers a new perspective in the preservation of fertility in young women with cervical cancer. Additional studies are required in a selected population.
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Copy and paste a formatted citation
Spandidos Publications style
Feng Y, Cao T, Wang Y, Huang H, Xie Y and Liu J: Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature. Mol Clin Oncol 5: 411-416, 2016.
APA
Feng, Y., Cao, T., Wang, Y., Huang, H., Xie, Y., & Liu, J. (2016). Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature. Molecular and Clinical Oncology, 5, 411-416. https://doi.org/10.3892/mco.2016.972
MLA
Feng, Y., Cao, T., Wang, Y., Huang, H., Xie, Y., Liu, J."Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature". Molecular and Clinical Oncology 5.4 (2016): 411-416.
Chicago
Feng, Y., Cao, T., Wang, Y., Huang, H., Xie, Y., Liu, J."Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature". Molecular and Clinical Oncology 5, no. 4 (2016): 411-416. https://doi.org/10.3892/mco.2016.972
Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y, Cao T, Wang Y, Huang H, Xie Y and Liu J: Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature. Mol Clin Oncol 5: 411-416, 2016.
APA
Feng, Y., Cao, T., Wang, Y., Huang, H., Xie, Y., & Liu, J. (2016). Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature. Molecular and Clinical Oncology, 5, 411-416. https://doi.org/10.3892/mco.2016.972
MLA
Feng, Y., Cao, T., Wang, Y., Huang, H., Xie, Y., Liu, J."Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature". Molecular and Clinical Oncology 5.4 (2016): 411-416.
Chicago
Feng, Y., Cao, T., Wang, Y., Huang, H., Xie, Y., Liu, J."Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature". Molecular and Clinical Oncology 5, no. 4 (2016): 411-416. https://doi.org/10.3892/mco.2016.972
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