Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma

Kaya,Bulent; Çiçek,Onur; Erdi,Fatih; Findik,Siddika; Karatas,Yasar; Esen,Hasan; Keskin,Fatih; Kalkan,Erdal

doi:10.3892/mco.2016.974

October-2016 Volume 5 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October-2016 Volume 5 Issue 4

Full Size Image

Article

Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma

Authors:
- Bulent Kaya
- Onur Çiçek
- Fatih Erdi
- Siddika Findik
- Yasar Karatas
- Hasan Esen
- Fatih Keskin
- Erdal Kalkan
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya 42080, Turkey, Department of Neurosurgery, Ministry of Health, Konya Numune Hospital, Selçuklu, Konya 42060, Turkey, Department of Pathology, Meram Faculty of Medicine, Necmettin Erbakan University, Meram, Konya 42080, Turkey
Pages: 343-346
|
Published online on: August 2, 2016

https://doi.org/10.3892/mco.2016.974
Expand metrics +

Abstract

The present study was designed to evaluate the expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and thioredoxin reductase 1 (TrxR1) in glioblastoma multiforme (GBM) with and without intratumoral hemorrhage. Surgically resected human GBM samples from 20 patients who underwent surgery at our institute were extracted from the histopathological specimens and divided into two groups. A total of 10 samples from each type of GBM (World Health Organization grade IV, intratumoral hemorrhage‑positive or ‑negative) were included in each group. VEGF, bFGF and TrxR1 expression was analyzed using immunohistochemistry and the results were compared between groups. VEGF and bFGF immunoreactivity was significantly higher in GBMs containing intratumoral hemorrhage. Furthermore, VEGF, bFGF and TrxR1 immunointensity was significantly higher in GBMs containing intratumoral hemorrhage. Thus, the present study demonstrated a higher VEGF, bFGF and TrxR1 expression in GBMs contain intratumoral hemorrhage, indicatiogn a role of VEGF, bFGF and TrxR1 expression in the promotion of tumoral angiogenesis and tumoral growth by complex mechanisms that require further elucidation.

View Figures

View References

1	Zhang M, Ye G, Li J and Wang Y: Recent advance in molecular angiogenesis in glioblastoma: The challenge and hope for anti-angiogenic therapy. Brain Tumor Pathol. 32:229–236. 2015. View Article : Google Scholar : PubMed/NCBI
2	Arnér ES and Holmgren A: The thioredoxin system in cancer. Semin Cancer Biol. 16:420–426. 2006. View Article : Google Scholar : PubMed/NCBI
3	JinKim Y, Hyun Kim C, Hwan Cheong J and Min Kim J: Relationship between expression of vascular endothelial growth factor and intratumoral hemorrhage in human pituitary adenomas. Tumori. 97:639–646. 2011.PubMed/NCBI
4	Gatson NN, Chiocca EA and Kaur B: Anti-angiogenic gene therapy in the treatment of malignant gliomas. Neurosci Lett. 527:62–70. 2012. View Article : Google Scholar : PubMed/NCBI
5	Stiver SI: Angiogenesis and its role in the behavior of astrocytic brain tumors. Front Biosci. 9:3105–3123. 2004. View Article : Google Scholar : PubMed/NCBI
6	Hara A and Okayasu I: Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: Correlation with angiogenesis and prognostic significance. Acta Neuropathol. 108:43–48. 2004. View Article : Google Scholar : PubMed/NCBI
7	Jang FF, Wei W and De WM: Vascular endothelial growth factor and basic fibroblast growth factor expression positively correlates with angiogenesis and peritumoural brain oedema in astrocytoma. J Ayub Med Coll Abbottabad. 20:105–109. 2008.PubMed/NCBI
8	Dunn LL, Buckle AM, Cooke JP and Ng MK: The emerging role of the thioredoxin system in angiogenesis. Arterioscler Thromb Vasc Biol. 30:2089–2098. 2010. View Article : Google Scholar : PubMed/NCBI
9	Yagublu V, Arthur JR, Babayeva SN, Nicol F, Post S and Keese M: Expression of selenium-containing proteins in human colon carcinoma tissue. Anticancer Res. 31:2693–2698. 2011.PubMed/NCBI
10	Holash J, Maisonpierre PC, Compton D, Boland P, Alexander CR, Zagzag D, Yancopoulos GD and Wiegand SJ: Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science. 284:1994–1998. 1999. View Article : Google Scholar : PubMed/NCBI
11	Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI
12	Haapasalo H, Kyläniemi M, Paunul N, Kinnula VL and Soini Y: Expression of antioxidant enzymes in astrocytic brain tumors. Brain Pathol. 13:155–164. 2003. View Article : Google Scholar : PubMed/NCBI
13	ElSayed M and Taha MM: Immunohistochemical expression of cycloxygenase-2 in astrocytoma: Correlation with angiogenesis, tumor progression and survival. Turk Neurosurg. 21:27–35. 2011.PubMed/NCBI
14	Torp SH and Alsaker M: Ki-67 immunoreactivity, basic fibroblastic growth factor (bFGF) expression, and microvessel density as supplementary prognostic tools in low-grade astrocytomas. An immunohistochemical study with special reference to the reliability of different Ki-67 anti. Pathol Res Pract. 198:261–265. 2002. View Article : Google Scholar : PubMed/NCBI
15	Cheng SY, Nagane M, Huang HS and Cavenee WK: Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189. Proc Natl Acad Sci USA. 94:12081–12087. 1997. View Article : Google Scholar : PubMed/NCBI
16	Plate KH and Risau W: Angiogenesis in malignant gliomas. Glia. 15:339–347. 1995. View Article : Google Scholar : PubMed/NCBI
17	Morrison RS, Yamaguchi F, Saya H, Bruner JM, Yahanda AM, Donehower LA and Berger M: Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas. J Neurooncol. 18:207–216. 1994. View Article : Google Scholar : PubMed/NCBI
18	Bian XW, Du LL, Shi JQ, Cheng YS and Liu FX: Correlation of bFGF, FGFR-1 and VEGF expression with vascularity and malignancy of human astrocytomas. Anal Quant Cytol Histol. 22:267–274. 2000.PubMed/NCBI
19	Harrigan MR: Angiogenic factors in the central nervous system. Neurosurgery. 53:639–660; discussion 660-661. 2003. View Article : Google Scholar : PubMed/NCBI
20	Jung S, Moon KS, Jung TY, Kim IY, Lee YH, Rhu HH, Sun HS, Jeong YI, Kim KK and Kang SS: Possible pathophysiological role of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in metastatic brain tumor-associated intracerebral hemorrhage. J Neurooncol. 76:257–263. 2006. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma

This article is mentioned in:

Abstract

Figure 1

Related Articles