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Article

Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma

  • Authors:
    • Ana Cebollero
    • Teresa Puértolas
    • Isabel Pajares
    • Lourdes Calera
    • Antonio Antón
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, University Hospital Miguel Servet, 50009 Zaragoza, Spain
  • Pages: 458-462
    |
    Published online on: August 4, 2016
       https://doi.org/10.3892/mco.2016.978
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Abstract

A retrospective observational study was conducted on patients diagnosed with serine/threonine-protein kinase B-Raf (BRAF)‑mutated metastatic melanoma, who underwent first‑line therapy with BRAF and mitogen‑activated protein kinase kinase (MEK) inhibitors (vemurafenib, dabrafenib or a combination of dabrafenib and trametinib) at the Miguel Servet University Hospital (Zaragoza, Spain) between November, 2011 and August, 2015. The aim of this study was to analyse the toxicity produced by BRAF and MEK inhibitors. The most common toxicities were similar to those published in clinical trials, particularly arthralgia, alopecia and photosensitivity in the vemurafenib group; asthenia, hyperkeratosis and dry skin in the dabrafenib group; and diarrhoea and dry skin in the dabrafenib plus trametinib group. Toxicities that had not been described in clinical trials were also identified. Thus, the present study confirmed that the results obtained in clinical trials are similar to those obtained in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Cebollero A, Puértolas T, Pajares I, Calera L and Antón A: Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma. Mol Clin Oncol 5: 458-462, 2016.
APA
Cebollero, A., Puértolas, T., Pajares, I., Calera, L., & Antón, A. (2016). Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma. Molecular and Clinical Oncology, 5, 458-462. https://doi.org/10.3892/mco.2016.978
MLA
Cebollero, A., Puértolas, T., Pajares, I., Calera, L., Antón, A."Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma". Molecular and Clinical Oncology 5.4 (2016): 458-462.
Chicago
Cebollero, A., Puértolas, T., Pajares, I., Calera, L., Antón, A."Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma". Molecular and Clinical Oncology 5, no. 4 (2016): 458-462. https://doi.org/10.3892/mco.2016.978
Copy and paste a formatted citation
x
Spandidos Publications style
Cebollero A, Puértolas T, Pajares I, Calera L and Antón A: Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma. Mol Clin Oncol 5: 458-462, 2016.
APA
Cebollero, A., Puértolas, T., Pajares, I., Calera, L., & Antón, A. (2016). Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma. Molecular and Clinical Oncology, 5, 458-462. https://doi.org/10.3892/mco.2016.978
MLA
Cebollero, A., Puértolas, T., Pajares, I., Calera, L., Antón, A."Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma". Molecular and Clinical Oncology 5.4 (2016): 458-462.
Chicago
Cebollero, A., Puértolas, T., Pajares, I., Calera, L., Antón, A."Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma". Molecular and Clinical Oncology 5, no. 4 (2016): 458-462. https://doi.org/10.3892/mco.2016.978
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