Polaprezinc protects normal intestinal epithelium against exposure to ionizing radiation in mice

Odawara,Soichi; Doi,Hiroshi; Shikata,Toshiyuki; Kitajima,Kazuhiro; Suzuki,Hitomi; Niwa,Yasue; Kosaka,Kengo; Tarutani,Kazuo; Tsujimura,Tohru; Kamikonya,Norihiko; Hirota,Shozo

doi:10.3892/mco.2016.983

October-2016 Volume 5 Issue 4

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October-2016 Volume 5 Issue 4

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Article Open Access

Polaprezinc protects normal intestinal epithelium against exposure to ionizing radiation in mice

Authors:
- Soichi Odawara
- Hiroshi Doi
- Toshiyuki Shikata
- Kazuhiro Kitajima
- Hitomi Suzuki
- Yasue Niwa
- Kengo Kosaka
- Kazuo Tarutani
- Tohru Tsujimura
- Norihiko Kamikonya
- Shozo Hirota
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Affiliations: Department of Radiology, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan, Department of Pharmacy, Hyogo College of Medicine Sasayama Medical Center, Sasayama, Hyogo 669‑2321, Japan, Department of Therapeutic Radiology, Uji‑Tokushukai Medical Center, Uji, Kyoto 611‑0041, Japan, Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan

Copyright: © Odawara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 377-381
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Published online on: August 8, 2016

https://doi.org/10.3892/mco.2016.983
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Abstract

Polaprezinc (PZ), an antiulcer drug, has been reported to have antioxidant effects. The purpose of the present study was to assess the radioprotective effects of PZ in the normal intestine of C57BL/6J mice. PZ was orally administered at 100 mg/kg body weight in the drinking water. Firstly, the present study compared the survival of normal intestinal crypt epithelial cells with mice that received PZ prior to or following irradiation. Next, the present study examined the sequential changes of the incidence of apoptosis in the normal intestine of mice that received irradiation. The mice that received PZ prior to irradiation demonstrated a stronger protective effect on the normal intestine compared with those that received PZ after irradiation. The present study therefore administrated PZ 2 h before irradiation in the subsequent experiments. The mice receiving PZ developed fewer apoptotic cells in the duodenum, jejunum and ileum. Radiation‑induced cell death occurred with a peak at position 10 or lower from the base of the crypt axis, and was subsequently reduced by PZ treatment. Pretreatment with PZ protected the normal intestinal tissues from radiation‑induced apoptosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Polaprezinc protects normal intestinal epithelium against exposure to ionizing radiation in mice

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