Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
October-2016 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2016 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non‑Hodgkin lymphoma

  • Authors:
    • Yan Ma
    • Meijuan Yan
    • Hua Huang
    • Li Zhang
    • Qian Wang
    • Yaqi Zhao
    • Jianmei Zhao
  • View Affiliations / Copyright

    Affiliations: Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 357-364
    |
    Published online on: August 10, 2016
       https://doi.org/10.3892/mco.2016.986
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Non-Hodgkin lymphoma (NHL) is a primary tumor arising in lymph nodes and lymphoid tissue. The incidence of NHL is increasing at an annual rate of 3%. The human Jun activation domain‑binding protein 1/COP9 signalosome subunit 5 (Jab1/CSN5) is a negative regulator of the cell cycle inhibitor p27Kip1 and abnormal expression of Jab1 is correlated with reduced p27 expression and associated with advanced tumor stage and poor prognosis in several human cancers. F‑box protein S‑phase kinase‑interacting protein‑2 (Skp2), the substrate recognition subunit of the Skp1‑Cul1‑F‑box protein ubiquitin protein ligase complex, is required for the ubiquitination and consequent degradation of p27. The Skp2 protein is overexpressed in several human cancers and is associated with the degree of differentiation and the prognosis. The aim of the present study was to investigate the expression status of p27Kip1, Jab1 and Skp2 by immunohistochemistry, and assess their prognostic significance in patients with NHL. Immunohistochemical analysis revealed an inverse association between Jab1 and p27 in NHL tissue samples. Kaplan‑Meier analysis demonstrated that Jab1 overexpression, Skp2 overexpression and low p27 expression were significantly associated with poor prognosis. Among clinicopathological parameters, overexpression of Jab1 was significantly associated with tumor size and International Prognostic Index (IPI), whereas Skp2 expression was significantly associated with metastasis and IPI. These findings suggest that the overexpression of Jab1 or Skp2 plays an important role in the pathogenesis of NHL. Thus, the expression of p27Kip1, Jab1 and Skp2 provided a clinical reference for the treatment of NHL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Wu M and Zhu J: Changes in nutrition metabolism of lymphoma after treatment and the nutritional supports. Acta Academiae Medicinae Sinicae. 36:446–449. 2014.(In Chinese). PubMed/NCBI

2 

Fu ZY, Zhu J, Song YQ, Liu WP, Ji XQ and Zhan SY: Prognostic analysis of 525 Chinese patients with diffuse large B-cell lymphoma. J Peking Univ (Health Sci). 46:405–411. 2014.(In Chinese).

3 

Zhao H, Bauzon F, Bi E, Yu JJ, Fu H, Lu Z, Cui J, Jeon H, Zang X, Ye BH and Zhu L: Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age. J Biol Chem. 290:5797–5809. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Ha SY, Lee CH, Chang HK, Chang S, Kwon KY, Lee EH, Roh MS and Seo B: Differential expression of forkhead box M1 and its downstream cyclin-dependent kinase inhibitors p27(kip1) and p21(waf1/cip1) in the diagnosis of pulmonary neuroendocrine tumours. Histopathology. 60:731–739. View Article : Google Scholar : PubMed/NCBI

5 

Sherr CJ and Roberts JM: CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–1512. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Dahinden C, Ingold B, Wild P, Boysen G, Luu VD, Montani M, Kristiansen G, Sulser T, Bühlmann P, Moch H and Schraml P: Mining tissue microarray data to uncover combinations of biomarker expression patterns that improve intermediate staging and grading of clear cell renal cell cancer. Clin Cancer Res. 16:88–98. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Claret FX, Hibi M, Dhut S, Toda T and Karin M: A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature. 383:453–457. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Chamovitz DA and Segal D: JAB1/CSN5 and the COP9 signalosome. A complex situation. EMBO Rep. 2:96–101. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Schwechheimer C and Deng XW: COP9 signalosome revisited: A novel mediator of protein degradation. Trends Cell Biol. 11:420–426. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Sankar U and Means AR: Gfer is a critical regulator of HSC proliferation. Cell Cycle. 10:2263–2268. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Porrello E, Rivellini C, Dina G, Triolo D, Del Carro U, Ungaro D, Panattoni M, Feltri ML, Wrabetz L, Pardi R, et al: Jab1 regulates Schwann cell proliferation and axonal sorting through p27. J Exp Med. 211:29–43. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, Yoshida M, Yoneda-Kato N and Kato JY: The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J Biol Chem. 277:2302–2310. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Li J, Wang Y, Yang C, Wang P, Oelschlager DK, Zheng Y, Tian DA, Grizzle WE, Buchsbaum DJ and Wan M: Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1. Mol Pharmacol. 76:81–90. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Sui L, Dong Y, Watanabe Y, Yamaguchi F, Sugimoto K and Tokuda M: Clinical significance of Skp2 expression, alone and combined with Jab1 and p27 in epithelial ovarian tumors. Oncol Rep. 15:765–771. 2006.PubMed/NCBI

15 

Kitagawa K, Kotake Y and Kitagawa M: Ubiquitin-mediated control of oncogene and tumor suppressor gene products. Cancer Sci. 100:1374–1381. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Serres MP, Zlotek-Zlotkiewicz E, Concha C, Gurian-West M, Daburon V, Roberts JM and Besson A: Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro. Oncogene. 30:2846–2858. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Kim JH, Go HY, Jin DH, Kim HP, Hong MH, Chung WY, Park JH, Jang JB, Jung H, Shin YC, et al: Inhibition of the PI3K-Akt/PKB survival pathway enhanced an ethanol extract of Rhus verniciflua Stokes-induced apoptosis via a mitochondrial pathway in AGS gastric cancer cell lines. Cancer Lett. 265:197–205. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Hung WC, Tseng WL, Shiea J and Chang HC: Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells. Cancer Lett. 288:156–161. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Tosco P, La Terra Maggiore GM, Forni P, Berrone S, Chiusa L and Garzino-Demo P: Correlation between Skp2 expression and nodal metastasis in stage I and II oral squamous cell carcinomas. Oral Dis. 17:102–108. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Signoretti S, Di Marcotullio L, Richardson A, Ramaswamy S, Isaac B, Rue M, Monti F, Loda M and Pagano M: Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J Clin Invest. 110:633–641. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Hershko D, Bornstein G, Ben-Izhak O, Carrano A, Pagano M, Krausz MM and Hershko A: Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. Cancer. 91:1745–1751. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Gstaiger M, Jordan R, Lim M, Catzavelos C, Mestan J, Slingerland J and Krek W: Skp2 is oncogenic and overexpressed in human cancers. Proc Natl Acad Sci USA. 98:5043–5048. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Di Vizio D, Demichelis F, Simonetti S, Pettinato G, Terracciano L, Tornillo L, Freeman MR and Insabato L: Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumours. BMC Cancer. 8:1342008. View Article : Google Scholar

24 

Rassidakis GZ, Claret FX, Lai R, et al: Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic an aplastic cell lymphoma. Clin Cancer Res. 9:1121–1128. 2003.PubMed/NCBI

25 

Xie F, Liu H, Zhu YH, Qin YR, Dai Y, Zeng T, Chen L, Nie C, Tang H, Li Y, et al: Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma. BMC Cancer. 11:862011. View Article : Google Scholar : PubMed/NCBI

26 

Ahn J, Hong SA, Lee SE, Kim J, Oh YS, Park SJ and Chung YJ: Cytoplasmic localization of Jab1 and p27Kip1 might be associated with invasiveness of papillary thyroid carcinoma. Endocr J. 56:707–713. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Seki R, Ohshima K, Fujisaki T, Uike N, Kawano F, Gondo H, Makino S, Eto T, Moriuchi Y, Taguchi F, et al: Prognostic significance of S-phase kinase-associated protein 2 and p27Kip1 in patients with diffuse large B-cell lymphoma: Effects of rituximab. Ann Oncol. 21:833–841. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P and Massagué J: Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 78:59–66. 1994. View Article : Google Scholar : PubMed/NCBI

29 

Carrano AC, Eytan E, Hershko A and Pagano M: SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol. 1:193–199. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Qi M, Liu D, Zhang S, Hu P and Sang T: Inhibition of S-phase kinase-associated protein 2-mediated p27 degradation suppresses tumorigenesis and the progression of hepatocellular carcinoma. Mol Med Rep. 11:3934–3940. 2015.PubMed/NCBI

31 

Hashimoto N, Yachida S, Okano K, Wakabayashi H, Imaida K, Kurokohchi K, Masaki T, Kinoshita H, Tominaga M, Ajiki T, et al: Immunohistochemically detected expression of p27(Kip1) and Skp2 predicts survival in patients with intrahepatic cholangiocarcinomas. Ann Surg Oncol. 16:395–403. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Kouvaraki MA, Korapati AL, Rassidakis GZ, Tian L, Zhang Q, Chiao P, Ho L, Evans DB and Claret FX: Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27Kip1 in pancreatic adenocarcinoma. Cancer Res. 66:8581–8589. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C and Dubiel W: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. Embo J. 20:1630–1639. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Naumann M, Bech-Otschir D, Huang X, Ferrell K and Dubiel W: COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J Biol Chem. 274:35297–35300. 1999. View Article : Google Scholar : PubMed/NCBI

35 

Pan Y, Zhang Q, Tian L, Wang X, Fan X, Zhang H, Claret FX and Yang H: Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma. Cancer Res. 72:1890–1900. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Lwin T, Hazlehurst LA, Dessureault S, Lai R, Bai W, Sotomayor E, Moscinski LC, Dalton WS and Tao J: Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. Blood. 110:1631–1638. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Dowen SE, Scott A, Mukherjee G and Stanley MA: Overexpression of Skp2 in carcinoma of the cervix does not correlate inversely with p27 expression. Int J Cancer. 105:326–330. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma Y, Yan M, Huang H, Zhang L, Wang Q, Zhao Y and Zhao J: Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non‑Hodgkin lymphoma. Mol Clin Oncol 5: 357-364, 2016.
APA
Ma, Y., Yan, M., Huang, H., Zhang, L., Wang, Q., Zhao, Y., & Zhao, J. (2016). Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non‑Hodgkin lymphoma. Molecular and Clinical Oncology, 5, 357-364. https://doi.org/10.3892/mco.2016.986
MLA
Ma, Y., Yan, M., Huang, H., Zhang, L., Wang, Q., Zhao, Y., Zhao, J."Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non‑Hodgkin lymphoma". Molecular and Clinical Oncology 5.4 (2016): 357-364.
Chicago
Ma, Y., Yan, M., Huang, H., Zhang, L., Wang, Q., Zhao, Y., Zhao, J."Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non‑Hodgkin lymphoma". Molecular and Clinical Oncology 5, no. 4 (2016): 357-364. https://doi.org/10.3892/mco.2016.986
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Y, Yan M, Huang H, Zhang L, Wang Q, Zhao Y and Zhao J: Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non‑Hodgkin lymphoma. Mol Clin Oncol 5: 357-364, 2016.
APA
Ma, Y., Yan, M., Huang, H., Zhang, L., Wang, Q., Zhao, Y., & Zhao, J. (2016). Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non‑Hodgkin lymphoma. Molecular and Clinical Oncology, 5, 357-364. https://doi.org/10.3892/mco.2016.986
MLA
Ma, Y., Yan, M., Huang, H., Zhang, L., Wang, Q., Zhao, Y., Zhao, J."Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non‑Hodgkin lymphoma". Molecular and Clinical Oncology 5.4 (2016): 357-364.
Chicago
Ma, Y., Yan, M., Huang, H., Zhang, L., Wang, Q., Zhao, Y., Zhao, J."Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non‑Hodgkin lymphoma". Molecular and Clinical Oncology 5, no. 4 (2016): 357-364. https://doi.org/10.3892/mco.2016.986
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team