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October-2016 Volume 5 Issue 4

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Article Open Access

Chemotherapy‑induced fatal hepatitis B virus reactivation in a small‑cell lung cancer patient

  • Authors:
    • Lei Qin
    • Fang Wang
    • Bing‑Wen Zou
    • Zhen‑Yu Ding
  • View Affiliations / Copyright

    Affiliations: Division of Head and Neck Cancer, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China, Division of Thoracic Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 382-384
    |
    Published online on: August 11, 2016
       https://doi.org/10.3892/mco.2016.989
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Abstract

Hepatitis B virus (HBV) reactivation during chemotherapy is a major concern and is widely reported, particularly in association with hematological malignancies and lymphomas. While lung cancer ranks first in incidence and mortality worldwide, HBV reactivation has been largely overlooked in this disease. As regards small‑cell lung cancer (SCLC), HBV reactivation has rarely been reported. We herein report the case of a hepatitis B surface antigen‑seropositive SCLC patient in whom HBV was reactivated during the course of chemotherapy, despite preemptive use of lamivudine. The patient developed fulminant viral hepatitis and succumbed to liver failure. The aim of this report was to highlight the major but overlooked issue of HBV reactivation in SCLC, and suggest that agents more potent than lamivudine may be more efficacious in high‑risk patients.
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Copy and paste a formatted citation
Spandidos Publications style
Qin L, Wang F, Zou BW and Ding ZY: Chemotherapy‑induced fatal hepatitis B virus reactivation in a small‑cell lung cancer patient. Mol Clin Oncol 5: 382-384, 2016.
APA
Qin, L., Wang, F., Zou, B., & Ding, Z. (2016). Chemotherapy‑induced fatal hepatitis B virus reactivation in a small‑cell lung cancer patient. Molecular and Clinical Oncology, 5, 382-384. https://doi.org/10.3892/mco.2016.989
MLA
Qin, L., Wang, F., Zou, B., Ding, Z."Chemotherapy‑induced fatal hepatitis B virus reactivation in a small‑cell lung cancer patient". Molecular and Clinical Oncology 5.4 (2016): 382-384.
Chicago
Qin, L., Wang, F., Zou, B., Ding, Z."Chemotherapy‑induced fatal hepatitis B virus reactivation in a small‑cell lung cancer patient". Molecular and Clinical Oncology 5, no. 4 (2016): 382-384. https://doi.org/10.3892/mco.2016.989
Copy and paste a formatted citation
x
Spandidos Publications style
Qin L, Wang F, Zou BW and Ding ZY: Chemotherapy‑induced fatal hepatitis B virus reactivation in a small‑cell lung cancer patient. Mol Clin Oncol 5: 382-384, 2016.
APA
Qin, L., Wang, F., Zou, B., & Ding, Z. (2016). Chemotherapy‑induced fatal hepatitis B virus reactivation in a small‑cell lung cancer patient. Molecular and Clinical Oncology, 5, 382-384. https://doi.org/10.3892/mco.2016.989
MLA
Qin, L., Wang, F., Zou, B., Ding, Z."Chemotherapy‑induced fatal hepatitis B virus reactivation in a small‑cell lung cancer patient". Molecular and Clinical Oncology 5.4 (2016): 382-384.
Chicago
Qin, L., Wang, F., Zou, B., Ding, Z."Chemotherapy‑induced fatal hepatitis B virus reactivation in a small‑cell lung cancer patient". Molecular and Clinical Oncology 5, no. 4 (2016): 382-384. https://doi.org/10.3892/mco.2016.989
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