Open Access

Allogeneic stem cell transplantation in a blast‑phase chronic myeloid leukemia patient with carbapenem‑resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report

  • Authors:
    • Bulent Kantarcioglu
    • Huseyin Saffet Bekoz
    • Fatih Erkam Olgun
    • Beytullah Cakal
    • Burak Arkan
    • Halil Turkoglu
    • Ali Mert
    • Deniz Sargin
  • View Affiliations

  • Published online on: August 17, 2016     https://doi.org/10.3892/mco.2016.995
  • Pages: 347-350
  • Copyright: © Kantarcioglu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome is generally poor. Allogeneic stem cell transplantation (allo‑SCT) is the only potentially curative treatment option for advanced‑phase CML. Infections caused by carbapenem‑resistant Klebsiella pneumoniae (CRKP) isolates are associated with high morbidity and mortality rates, particularly in patients with haematological malignancies. Infection and colonization by these multiresistant bacteria may represent a challenge in SCT recipients for the management of post‑transplantation complications, as well as for the eligibility to receive a transplant in patients who acquire the pathogen prior to the procedure. We herein report the case of a blast‑phase CML patient with a highly resistant, CRKP‑associated tricuspid valve endocarditis, who was treated with a combination of systemic antimicrobial therapy and surgical valve repair, and subsequently underwent a successful allo‑SCT.
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October-2016
Volume 5 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Kantarcioglu B, Bekoz HS, Olgun FE, Cakal B, Arkan B, Turkoglu H, Mert A and Sargin D: Allogeneic stem cell transplantation in a blast‑phase chronic myeloid leukemia patient with carbapenem‑resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report. Mol Clin Oncol 5: 347-350, 2016
APA
Kantarcioglu, B., Bekoz, H.S., Olgun, F.E., Cakal, B., Arkan, B., Turkoglu, H. ... Sargin, D. (2016). Allogeneic stem cell transplantation in a blast‑phase chronic myeloid leukemia patient with carbapenem‑resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report. Molecular and Clinical Oncology, 5, 347-350. https://doi.org/10.3892/mco.2016.995
MLA
Kantarcioglu, B., Bekoz, H. S., Olgun, F. E., Cakal, B., Arkan, B., Turkoglu, H., Mert, A., Sargin, D."Allogeneic stem cell transplantation in a blast‑phase chronic myeloid leukemia patient with carbapenem‑resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report". Molecular and Clinical Oncology 5.4 (2016): 347-350.
Chicago
Kantarcioglu, B., Bekoz, H. S., Olgun, F. E., Cakal, B., Arkan, B., Turkoglu, H., Mert, A., Sargin, D."Allogeneic stem cell transplantation in a blast‑phase chronic myeloid leukemia patient with carbapenem‑resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report". Molecular and Clinical Oncology 5, no. 4 (2016): 347-350. https://doi.org/10.3892/mco.2016.995