Allogeneic stem cell transplantation in a blast‑phase chronic myeloid leukemia patient with carbapenem‑resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report

Kantarcioglu,Bulent; Bekoz,Huseyin Saffet; Olgun,Fatih Erkam; Cakal,Beytullah; Arkan,Burak; Turkoglu,Halil; Mert,Ali; Sargin,Deniz

doi:10.3892/mco.2016.995

October-2016 Volume 5 Issue 4

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October-2016 Volume 5 Issue 4

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Case Report Open Access

Allogeneic stem cell transplantation in a blast‑phase chronic myeloid leukemia patient with carbapenem‑resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report

Authors:
- Bulent Kantarcioglu
- Huseyin Saffet Bekoz
- Fatih Erkam Olgun
- Beytullah Cakal
- Burak Arkan
- Halil Turkoglu
- Ali Mert
- Deniz Sargin
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Affiliations: Division of Hematology, Department of Internal Medicine, Istanbul Medipol University, 34214 Istanbul, Turkey, Department of Cardiology, Istanbul Medipol University, 34214 Istanbul, Turkey, Department of Cardiovascular Surgery, Istanbul Medipol University, 34214 Istanbul, Turkey, Department of Infectious Diseases and Clinical Microbiology, Istanbul Medipol University, 34214 Istanbul, Turkey

Copyright: © Kantarcioglu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 347-350
|
Published online on: August 17, 2016

https://doi.org/10.3892/mco.2016.995
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Abstract

In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome is generally poor. Allogeneic stem cell transplantation (allo‑SCT) is the only potentially curative treatment option for advanced‑phase CML. Infections caused by carbapenem‑resistant Klebsiella pneumoniae (CRKP) isolates are associated with high morbidity and mortality rates, particularly in patients with haematological malignancies. Infection and colonization by these multiresistant bacteria may represent a challenge in SCT recipients for the management of post‑transplantation complications, as well as for the eligibility to receive a transplant in patients who acquire the pathogen prior to the procedure. We herein report the case of a blast‑phase CML patient with a highly resistant, CRKP‑associated tricuspid valve endocarditis, who was treated with a combination of systemic antimicrobial therapy and surgical valve repair, and subsequently underwent a successful allo‑SCT.

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