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Review Open Access

The role of peroxiredoxins in cancer (Review)

  • Authors:
    • Arianna Nicolussi
    • Sonia D'inzeo
    • Carlo Capalbo
    • Giuseppe Giannini
    • Anna Coppa
  • View Affiliations / Copyright

    Affiliations: Department of Experimental Medicine, Sapienza University of Rome, I‑00161 Rome, Italy, Department of Molecular Medicine, Sapienza University of Rome, I‑00161 Rome, Italy
    Copyright: © Nicolussi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 139-153
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    Published online on: January 10, 2017
       https://doi.org/10.3892/mco.2017.1129
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Abstract

Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22‑27 kDa) non‑seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides and peroxynitrite. They are highly involved in the control of various physiological functions, including cell growth, differentiation, apoptosis, embryonic development, lipid metabolism, the immune response, as well as cellular homeostasis. Although the protective role of PRDXs in cardiovascular and neurological diseases is well established, their role in cancer remains controversial. Increasing evidence suggests the involvement of PRDXs in carcinogenesis and in the development of drug resistance. Numerous types of cancer cells, in fact, are characterized by an increase in reactive oxygen species (ROS) production, and often exhibit an altered redox environment compared with normal cells. The present review focuses on the complex association between oxidant balance and cancer, and it provides a brief account of the involvement of PRDXs in tumorigenesis and in the development of chemoresistance.
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1 

Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M and Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 39:44–84. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Duracková Z: Some current insights into oxidative stress. Physiol Res. 59:459–469. 2010.PubMed/NCBI

3 

Xing M: Oxidative stress: A new risk factor for thyroid cancer. Endocr Relat Cancer. 19:C7–C11. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Dröge W: Free radicals in the physiological control of cell function. Physiol Rev. 82:47–95. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Giorgio M, Trinei M, Migliaccio E and Pelicci PG: Hydrogen peroxide: A metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol. 8:722–728. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Rhee SG, Bae YS, Lee SR and Kwon J: Hydrogen peroxide: A key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE. 2000:pe12000.PubMed/NCBI

7 

Cha MK, Kim HK and Kim IH: Thioredoxin-linked ‘thiol peroxidase’ from periplasmic space of Escherichia coli. J Biol Chem. 270:28635–28641. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Zhou Y, Wan XY, Wang HL, Yan ZY, Hou YD and Jin DY: Bacterial scavengase p20 is structurally and functionally related to peroxiredoxins. Biochem Biophys Res Commun. 233:848–852. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Nogoceke E, Gommel DU, Kiess M, Kalisz HM and Flohé L: A Unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculata. Biol Chem. 378:827–836. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Bryk R, Griffin P and Nathan C: Peroxynitrite reductase activity of bacterial peroxiredoxins. Nature. 407:211–215. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Hillas PJ, del Alba FS, Oyarzabal J, Wilks A and De Montellano PR Ortiz: The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis. J Biol Chem. 275:18801–18809. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Karplus PA: A primer on peroxiredoxin biochemistry. Free Radic Biol Med. 80:183–190. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Winterbourn CC: Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol. 4:278–286. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Kim K, Kim IH, Lee KY, Rhee SG and Stadtman ER: The isolation and purification of a specific ‘protector’ protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system. J Biol Chem. 263:4704–4711. 1988.PubMed/NCBI

15 

Chae HZ, Robison K, Poole LB, Church G, Storz G and Rhee SG: Cloning and sequencing of thiol-specific antioxidant from mammalian brain: Alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Proc Natl Acad Sci USA. 91:7017–7021. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, et al: Peroxiredoxins are conserved markers of circadian rhythms. Nature. 485:459–464. 2012.PubMed/NCBI

17 

Nelson KJ, Knutson ST, Soito L, Klomsiri C, Poole LB and Fetrow JS: Analysis of the peroxiredoxin family: Using active-site structure and sequence information for global classification and residue analysis. Proteins. 79:947–964. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Perkins A, Gretes MC, Nelson KJ, Poole LB and Karplus PA: Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes. Biochemistry. 51:7638–7650. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Hall A, Nelson K, Poole LB and Karplus PA: Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins. Antioxid Redox Signal. 15:795–815. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Dammeyer P and Arnér ES: Human protein atlas of redox systems-what can be learnt? Biochim Biophys Acta. 1810:111–138. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Rhee SG, Chae HZ and Kim K: Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med. 38:1543–1552. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Seo MS, Kang SW, Kim K, Baines IC, Lee TH and Rhee SG: Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. J Biol Chem. 275:20346–20354. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Kang SW, Baines IC and Rhee SG: Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. J Biol Chem. 273:6303–6311. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Fujii J, Ikeda Y, Kurahashi T and Homma T: Physiological and pathological views of peroxiredoxin 4. Free Radic Biol Med. 83:373–379. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Rhee SG, Kang SW, Chang TS, Jeong W and Kim K: Peroxiredoxin, a novel family of peroxidases. IUBMB Life. 52:35–41. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Hofmann B, Hecht HJ and Flohé L: Peroxiredoxins. Biol Chem. 383:347–364. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Declercq JP, Evrard C, Clippe A, Stricht DV, Bernard A and Knoops B: Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution. J Mol Biol. 311:751–759. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Monteiro G, Horta BB, Pimenta DC, Augusto O and Netto LE: Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C. Proc Natl Acad Sci USA. 104:4886–4891. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Karplus PA and Hall A: Structural survey of the peroxiredoxins. Subcell Biochem. 44:41–60. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Wood ZA, Poole LB, Hantgan RR and Karplus PA: Dimers to Doughnuts: Redox-sensitive oligomerization of 2-cysteine peroxiredoxins. Biochemistry. 41:5493–5504. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Barranco-Medina S, Lázaro JJ and Dietz KJ: The oligomeric conformation of peroxiredoxins links redox state to function. FEBS Lett. 583:1809–1816. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Fujii J and Ikeda Y: Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox Rep. 7:123–130. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Pisoschi AM and Pop A: The role of antioxidants in the chemistry of oxidative stress: A review. Eur J Med Chem. 97:55–74. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Fulda S, Gorman AM, Hori O and Samali A: Cellular stress responses: Cell survival and cell death. Int J Cell Biol. 2010:2140742010. View Article : Google Scholar : PubMed/NCBI

35 

Kamiguti AS, Serrander L, Lin K, Harris RJ, Cawley JC, Allsup DJ, Slupsky JR, Krause KH and Zuzel M: Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol. 175:8424–8430. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Tsao SM, Yin MC and Liu WH: Oxidant stress and B vitamins status in patients with non-small cell lung cancer. Nutr Cancer. 59:8–13. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Khandrika L, Kumar B, Koul S, Maroni P and Koul HK: Oxidative stress in prostate cancer. Cancer Lett. 282:125–136. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Patel BP, Rawal UM, Dave TK, Rawal RM, Shukla SN, Shah PM and Patel PS: Lipid peroxidation, total antioxidant status, and total thiol levels predict overall survival in patients with oral squamous cell carcinoma. Integr Cancer Ther. 6:365–372. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Szatrowski TP and Nathan CF: Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51:794–798. 1991.PubMed/NCBI

40 

Nishikawa M: Reactive oxygen species in tumor metastasis. Cancer Lett. 266:53–59. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Clerkin JS, Naughton R, Quiney C and Cotter TG: Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett. 266:30–36. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Krstić J, Trivanović D, Mojsilović S and Santibanez JF: Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and cancer progression. Oxid Med Cell Longev. 2015:6545942015. View Article : Google Scholar : PubMed/NCBI

43 

Ushio-Fukai M and Nakamura Y: Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett. 266:37–52. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Fiaschi T and Chiarugi P: Oxidative stress, tumor microenvironment, and metabolic reprogramming: A diabolic liaison. Int J Cell Biol. 2012:7628252012. View Article : Google Scholar : PubMed/NCBI

45 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Weinberg F and Chandel NS: Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci. 66:3663–3673. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Cairns RA, Harris IS and Mak TW: Regulation of cancer cell metabolism. Nat Rev Cancer. 11:85–95. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Park MH, Jo M, Kim YR, Lee CK and Hong JT: Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases. Pharmacol Ther. 163:1–23. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Taguchi K, Motohashi H and Yamamoto M: Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells. 16:123–140. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Kwee JK: A paradoxical chemoresistance and tumor suppressive role of antioxidant in solid cancer cells: A strange case of Dr. Jekyll and Mr. Hyde. Biomed Res Int. 2014:2098452014. View Article : Google Scholar : PubMed/NCBI

51 

Neumann CA, Cao J and Manevich Y: Peroxiredoxin 1 and its role in cell signaling. Cell Cycle. 8:4072–4078. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Kim YJ, Ahn JY, Liang P, Ip C, Zhang Y and Park YM: Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: Implication to tumor biology. Cancer Res. 67:546–554. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Thélie A, Papillier P, Pennetier S, Perreau C, Traverso JM, Uzbekova S, Mermillod P, Joly C, Humblot P and Dalbiès-Tran R: Differential regulation of abundance and deadenylation of maternal transcripts during bovine oocyte maturation in vitro and in vivo. BMC Dev Biol. 7:1252007. View Article : Google Scholar : PubMed/NCBI

54 

Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, Bronson RT, Fujiwara Y, Orkin SH and Van Etten RA: Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature. 424:561–565. 2003. View Article : Google Scholar : PubMed/NCBI

55 

Egler RA, Fernandes E, Rothermund K, Sereika S, de Souza-Pinto N, Jaruga P, Dizdaroglu M and Prochownik EV: Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1. Oncogene. 24:8038–8050. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C and Neumann CA: Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. EMBO J. 28:1505–1517. 2009. View Article : Google Scholar : PubMed/NCBI

57 

O'Leary PC, Terrile M, Bajor M, Gaj P, Hennessy BT, Mills GB, Zagozdzon A, O'Connor DP, Brennan DJ, Connor K, et al: Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer. Breast Cancer Res. 16:R792014. View Article : Google Scholar : PubMed/NCBI

58 

Park YH, Kim SU, Lee BK, Kim HS, Song IS, Shin HJ, Han YH, Chang KT, Kim JM, Lee DS, et al: Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway. Antioxid Redox Signal. 19:482–496. 2013. View Article : Google Scholar : PubMed/NCBI

59 

Godfrey R, Arora D, Bauer R, Stopp S, Müller JP, Heinrich T, Böhmer SA, Dagnell M, Schnetzke U, Scholl S, et al: Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/PTPRJ. Blood. 119:4499–4511. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Kim JH, Bogner PN, Baek SH, Ramnath N, Liang P, Kim HR, Andrews C and Park YM: Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target. Clin Cancer Res. 14:2326–2333. 2008. View Article : Google Scholar : PubMed/NCBI

61 

Quan C, Cha EJ, Lee HL, Han KH, Lee KM and Kim WJ: Enhanced expression of peroxiredoxin I and VI correlates with development, recurrence and progression of human bladder cancer. J Urol. 175:1512–1516. 2006. View Article : Google Scholar : PubMed/NCBI

62 

Chung KH, Lee DH, Kim Y, Kim TH, Huh JH, Chung SG, Lee S, Lee C, Ko JJ and An HJ: Proteomic identification of overexpressed PRDX 1 and its clinical implications in ovarian carcinoma. J Proteome Res. 9:451–457. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Ren P, Ye H, Dai L, Liu M, Liu X, Chai Y, Shao Q, Li Y, Lei N, Peng B, et al: Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma. Oncol Rep. 30:2297–2303. 2013.PubMed/NCBI

64 

Zhou J, Shen W, He X, Qian J, Liu S and Yu G: Overexpression of Prdx1 in hilar cholangiocarcinoma: A predictor for recurrence and prognosis. Int J Clin Exp Pathol. 8:9863–9874. 2015.PubMed/NCBI

65 

Sun YL, Cai JQ, Liu F, Bi XY, Zhou LP and Zhao XH: Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer. World J Gastroenterol. 21:10840–10852. 2015. View Article : Google Scholar : PubMed/NCBI

66 

Cai CY, Zhai LL, Wu Y and Tang ZG: Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer. Eur J Surg Oncol. 41:228–235. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Kinnula VL, Lehtonen S, Sormunen R, Kaarteenaho-Wiik R, Kang SW, Rhee SG and Soini Y: Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma. J Pathol. 196:316–323. 2002. View Article : Google Scholar : PubMed/NCBI

68 

Svendsen A, Verhoeff JJ, Immervoll H, Brøgger JC, Kmiecik J, Poli A, Netland IA, Prestegarden L, Planagumà J, Torsvik A, et al: Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathol. 122:495–510. 2011. View Article : Google Scholar : PubMed/NCBI

69 

Riddell JR, Maier P, Sass SN, Moser MT, Foster BA and Gollnick SO: Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1α. PLoS One. 7:e503942012. View Article : Google Scholar : PubMed/NCBI

70 

Jiang H, Wu L, Mishra M, Chawsheen HA and Wei Q: Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy. Am J Cancer Res. 4:445–460. 2014.PubMed/NCBI

71 

Ha B, Kim EK, Kim JH, Lee HN, Lee KO, Lee SY and Jang HH: Human peroxiredoxin 1 modulates TGF-β1-induced epithelial-mesenchymal transition through its peroxidase activity. Biochem Biophys Res Commun. 421:33–37. 2012. View Article : Google Scholar : PubMed/NCBI

72 

Du ZX, Yan Y, Zhang HY, Liu BQ, Gao YY, Niu XF, Guan Y, Meng X and Wang HQ: Suppression of MG132-mediated cell death by peroxiredoxin 1 through influence on ASK1 activation in human thyroid cancer cells. Endocr Relat Cancer. 17:553–560. 2010. View Article : Google Scholar : PubMed/NCBI

73 

Song IS, Kim SU, Oh NS, Kim J, Yu DY, Huang SM, Kim JM, Lee DS and Kim NS: Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells. Carcinogenesis. 30:1106–1114. 2009. View Article : Google Scholar : PubMed/NCBI

74 

Yanagawa T, Ishikawa T, Ishii T, Tabuchi K, Iwasa S, Bannai S, Omura K, Suzuki H and Yoshida H: Peroxiredoxin I expression in human thyroid tumors. Cancer Lett. 145:127–132. 1999. View Article : Google Scholar : PubMed/NCBI

75 

Nicolussi A, D'Inzeo S, Mincione G, Buffone A, Di Marcantonio MC, Cotellese R, Cichella A, Capalbo C, Di Gioia C, Nardi F, et al: PRDX1 and PRDX6 are repressed in papillary thyroid carcinomas via BRAF V600E-dependent and -independent mechanisms. Int J Oncol. 44:548–556. 2014.PubMed/NCBI

76 

Wood ZA, Poole LB and Karplus PA: Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science. 300:650–653. 2003. View Article : Google Scholar : PubMed/NCBI

77 

O'Neill JS and Reddy AB: Circadian clocks in human red blood cells. Nature. 469:498–503. 2011. View Article : Google Scholar : PubMed/NCBI

78 

Cho CS, Yoon HJ, Kim JY, Woo HA and Rhee SG: Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells. Proc Natl Acad Sci USA. 111:12043–12048. 2014. View Article : Google Scholar : PubMed/NCBI

79 

Avitabile D, Ranieri D, Nicolussi A, D'Inzeo S, Capriotti AL, Genovese L, Proietti S, Cucina A, Coppa A, Samperi R, et al: Peroxiredoxin 2 nuclear levels are regulated by circadian clock synchronization in human keratinocytes. Int J Biochem Cell Biol. 53:24–34. 2014. View Article : Google Scholar : PubMed/NCBI

80 

Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN and Dick TP: Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nat Chem Biol. 11:64–70. 2015. View Article : Google Scholar : PubMed/NCBI

81 

Rhee SG and Woo HA: Multiple functions of peroxiredoxins: Peroxidases, sensors and regulators of the intracellular messenger H2O2, and protein chaperones. Antioxid Redox Signal. 15:781–794. 2011. View Article : Google Scholar : PubMed/NCBI

82 

Huo YY, Li G, Duan RF, Gou Q, Fu CL, Hu YC, Song BQ, Yang ZH, Wu DC and Zhou PK: PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts. Free Radic Biol Med. 44:1578–1591. 2008. View Article : Google Scholar : PubMed/NCBI

83 

Barbosa AC, Funato N, Chapman S, McKee MD, Richardson JA, Olson EN and Yanagisawa H: Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol. 310:154–168. 2007. View Article : Google Scholar : PubMed/NCBI

84 

Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K and Ushijima T: Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res. 66:6080–6086. 2006. View Article : Google Scholar : PubMed/NCBI

85 

Lee DJ, Kang DH, Choi M, Choi YJ, Lee JY, Park JH, Park YJ, Lee KW and Kang SW: Peroxiredoxin-2 represses melanoma metastasis by increasing E-Cadherin/β-Catenin complexes in adherens junctions. Cancer Res. 73:4744–4757. 2013. View Article : Google Scholar : PubMed/NCBI

86 

Feng J, Fu Z, Guo J, Lu W, Wen K, Chen W, Wang H, Wei J and Zhang S: Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. Mol Med Rep. 10:867–873. 2014.PubMed/NCBI

87 

Pylväs M, Puistola U, Kauppila S, Soini Y and Karihtala P: Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis. Eur J Cancer. 46:1661–1667. 2010. View Article : Google Scholar : PubMed/NCBI

88 

Hellman K, Alaiya AA, Becker S, Lomnytska M, Schedvins K, Steinberg W, Hellström AC, Andersson S, Hellman U and Auer G: Differential tissue-specific protein markers of vaginal carcinoma. Br J Cancer. 100:1303–1314. 2009. View Article : Google Scholar : PubMed/NCBI

89 

Kim K, Yu M, Han S, Oh I, Choi YJ, Kim S, Yoon K, Jung M and Choe W: Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis. Oncol Rep. 21:1391–1396. 2009.PubMed/NCBI

90 

Basu A, Banerjee H, Rojas H, Martinez SR, Roy S, Jia Z, Lilly MB, De León M and Casiano CA: Differential expression of peroxiredoxins in prostate cancer: Consistent upregulation of PRDX3 and PRDX4. Prostate. 71:755–765. 2011. View Article : Google Scholar : PubMed/NCBI

91 

Zhang B, Wang K, He G, Guan X, Liu B, Liu Y and Bai Y: Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer. J Cancer Res Clin Oncol. 138:621–626. 2012. View Article : Google Scholar : PubMed/NCBI

92 

Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, Malinowska A, Czerwoniec A, Barankiewicz J, Domagala A, et al: Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma. Oncotarget. 7:1717–1731. 2016.PubMed/NCBI

93 

Stresing V, Baltziskueta E, Rubio N, Blanco J, Arriba MC, Valls J, Janier M, Clézardin P, Sanz-Pamplona R, Nieva C, et al: Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs. Oncogene. 32:724–735. 2013. View Article : Google Scholar : PubMed/NCBI

94 

Lu W, Fu Z, Wang H, Feng J, Wei J and Guo J: Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress. Mol Cell Biochem. 387:261–270. 2014. View Article : Google Scholar : PubMed/NCBI

95 

Watabe S, Hiroi T, Yamamoto Y, Fujioka Y, Hasegawa H, Yago N and Takahashi SY: SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria. Eur J Biochem. 249:52–60. 1997. View Article : Google Scholar : PubMed/NCBI

96 

Miranda-Vizuete A, Damdimopoulos AE and Spyrou G: The mitochondrial thioredoxin system. Antioxid Redox Signal. 2:801–810. 2000. View Article : Google Scholar : PubMed/NCBI

97 

Olmos Y, Sánchez-Gómez FJ, Wild B, García-Quintans N, Cabezudo S, Lamas S and Monsalve M: SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex. Antioxid Redox Signal. 19:1507–1521. 2013. View Article : Google Scholar : PubMed/NCBI

98 

Song IS, Jeong YJ, Jeong SH, Heo HJ, Kim HK, Bae KB, Park YH, Kim SU, Kim JM, Kim N, et al: FOXM1-Induced PRX3 regulates stemness and survival of colon cancer cells via maintenance of mitochondrial function. Gastroenterology. 149:1006–1016.e9. 2015. View Article : Google Scholar : PubMed/NCBI

99 

Li KK, Pang JC, Lau KM, Zhou L, Mao Y, Wang Y, Poon WS and Ng HK: MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3). Brain Pathol. 23:413–425. 2013. View Article : Google Scholar : PubMed/NCBI

100 

He HC, Zhu JG, Chen XB, Chen SM, Han ZD, Dai QS, Ling XH, Fu X, Lin ZY, Deng YH, et al: MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer. FEBS Lett. 586:2451–2458. 2012. View Article : Google Scholar : PubMed/NCBI

101 

Xi H, Gao YH, Han DY, Li QY, Feng LJ, Zhang W, Ji G, Xiao JC, Zhang HZ and Wei Q: Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells. FEBS Lett. 588:3390–3394. 2014. View Article : Google Scholar : PubMed/NCBI

102 

Choi JH, Kim TN, Kim S, Baek SH, Kim JH, Lee SR and Kim JR: Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas. Anticancer Res. 22:3331–3335. 2002.PubMed/NCBI

103 

Karihtala P, Mäntyniemi A, Kang SW, Kinnula VL and Soini Y: Peroxiredoxins in breast carcinoma. Clin Cancer Res. 9:3418–3424. 2003.PubMed/NCBI

104 

Ummanni R, Barreto F, Venz S, Scharf C, Barett C, Mannsperger HA, Brase JC, Kuner R, Schlomm T, Sauter G, et al: Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro. J Proteome Res. 11:2452–2466. 2012. View Article : Google Scholar : PubMed/NCBI

105 

Kim YS, Lee HL, Lee KB, Park JH, Chung WY, Lee KS, Sheen SS, Park KJ and Hwang SC: Nuclear factor E2-related factor 2 dependent overexpression of sulfiredoxin and peroxiredoxin III in human lung cancer. Korean J Intern Med. 26:304–313. 2011. View Article : Google Scholar : PubMed/NCBI

106 

Hu JX, Gao Q and Li L: Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer. Biomed Rep. 1:228–230. 2013.PubMed/NCBI

107 

Schulte J: Peroxiredoxin 4: A multifunctional biomarker worthy of further exploration. BMC Med. 9:1372011. View Article : Google Scholar : PubMed/NCBI

108 

Okado-Matsumoto A, Matsumoto A, Fujii J and Taniguchi N: Peroxiredoxin IV is a secretable protein with heparin-binding properties under reduced conditions. J Biochem. 127:493–501. 2000. View Article : Google Scholar : PubMed/NCBI

109 

Roumes H, Pires-Alves A, Gonthier-Maurin L, Dargelos E and Cottin P: Investigation of peroxiredoxin IV as a calpain-regulated pathway in cancer. Anticancer Res. 30:5085–5089. 2010.PubMed/NCBI

110 

Ikeda Y, Nakano M, Ihara H, Ito R, Taniguchi N and Fujii J: Different consequences of reactions with hydrogen peroxide and t-butyl hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4. J Biochem. 149:443–453. 2011. View Article : Google Scholar : PubMed/NCBI

111 

Zhu L, Yang K, Wang X, Wang X and Wang CC: A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding. PLoS One. 9:e1055292014. View Article : Google Scholar : PubMed/NCBI

112 

Ishii T, Warabi E and Yanagawa T: Novel roles of peroxiredoxins in inflammation, cancer and innate immunity. J Clin Biochem Nutr. 50:91–105. 2012. View Article : Google Scholar : PubMed/NCBI

113 

Mishra M, Jiang H, Wu L, Chawsheen HA and Wei Q: The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development. Cancer Lett. 366:150–159. 2015. View Article : Google Scholar : PubMed/NCBI

114 

Chen JH, Ni RZ, Xiao MB, Guo JG and Zhou JW: Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue. Hepatobiliary Pancreat Dis Int. 8:193–200. 2009.PubMed/NCBI

115 

Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, Sikes RA and Nelson PS: Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Res. 69:1739–1747. 2009. View Article : Google Scholar : PubMed/NCBI

116 

Chang KP, Yu JS, Chien KY, Lee CW, Liang Y, Liao CT, Yen TC, Lee LY, Huang LL, Liu SC, et al: Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology. J Proteome Res. 10:4935–4947. 2011. View Article : Google Scholar : PubMed/NCBI

117 

Karihtala P, Kauppila S, Soini Y and Arja-Jukkola-Vuorinen: Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas. BMC Cancer. 11:2622011. View Article : Google Scholar : PubMed/NCBI

118 

Karihtala P, Soini Y, Vaskivuo L, Bloigu R and Puistola U: DNA adduct 8-hydroxydeoxyguanosine, a novel putative marker of prognostic significance in ovarian carcinoma. Int J Gynecol Cancer. 19:1047–1051. 2009. View Article : Google Scholar : PubMed/NCBI

119 

Yi N, Xiao MB, Ni WK, Jiang F, Lu CH and Ni RZ: High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor. Mol Clin Oncol. 2:767–772. 2014.PubMed/NCBI

120 

Wei Q, Jiang H, Xiao Z, Baker A, Young MR, Veenstra TD and Colburn NH: Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling. Proc Natl Acad Sci USA. 108:7004–7009. 2011. View Article : Google Scholar : PubMed/NCBI

121 

Palande KK, Beekman R, van der Meeren LE, Beverloo HB, Valk PJ and Touw IP: The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia. PLoS One. 6:e163402011. View Article : Google Scholar : PubMed/NCBI

122 

Knoops B, Goemaere J, Van der Eecken V and Declercq JP: Peroxiredoxin 5: Structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin. Antioxid Redox Signal. 15:817–829. 2011. View Article : Google Scholar : PubMed/NCBI

123 

Nguyên-Nhu NT, Berck J, Clippe A, Duconseille E, Cherif H, Boone C, Van der Eecken V, Bernard A, Banmeyer I and Knoops B: Human peroxiredoxin 5 gene organization, initial characterization of its promoter and identification of alternative forms of mRNA. Biochim Biophys Acta. 1769:472–483. 2007. View Article : Google Scholar : PubMed/NCBI

124 

Graves JA, Metukuri M, Scott D, Rothermund K and Prochownik EV: Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc. J Biol Chem. 284:6520–6529. 2009. View Article : Google Scholar : PubMed/NCBI

125 

Kropotov A, Usmanova N, Serikov V, Zhivotovsky B and Tomilin N: Mitochondrial targeting of human peroxiredoxin V protein and regulation of PRDX5 gene expression by nuclear transcription factors controlling biogenesis of mitochondria. FEBS J. 274:5804–5814. 2007. View Article : Google Scholar : PubMed/NCBI

126 

Shiota M, Izumi H, Miyamoto N, Onitsuka T, Kashiwagi E, Kidani A, Hirano G, Takahashi M, Ono M, Kuwano M, et al: Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1. Cancer Sci. 99:1950–1959. 2008.PubMed/NCBI

127 

Bur H, Haapasaari KM, Turpeenniemi-Hujanen T, Kuittinen O, Auvinen P, Marin K, Koivunen P, Sormunen R, Soini Y and Karihtala P: Oxidative stress markers and mitochondrial antioxidant enzyme expression are increased in aggressive Hodgkin lymphomas. Histopathology. 65:319–327. 2014. View Article : Google Scholar : PubMed/NCBI

128 

Gérard AC, Many MC, Daumerie Ch, Knoops B and Colin IM: Peroxiredoxin 5 expression in the human thyroid gland. Thyroid. 15:205–209. 2005. View Article : Google Scholar : PubMed/NCBI

129 

Fernandez-Ranvier GG, Weng J, Yeh RF, Shibru D, Khafnashar E, Chung KW, Hwang J, Duh QY, Clark OH and Kebebew E: Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13. World J Surg. 32:873–881. 2008. View Article : Google Scholar : PubMed/NCBI

130 

Fisher AB: Peroxiredoxin 6: A bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. Antioxid Redox Signal. 15:831–844. 2011. View Article : Google Scholar : PubMed/NCBI

131 

Choi HJ, Kang SW, Yang CH, Rhee SG and Ryu SE: Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Nat Struct Biol. 5:400–406. 1998. View Article : Google Scholar : PubMed/NCBI

132 

Chowdhury I, Fisher AB, Christofidou-Solomidou M, Gao L, Tao JQ, Sorokina EM, Lien YC, Bates SR and Feinstein SI: Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic. Antioxid Redox Signal. 20:391–402. 2014. View Article : Google Scholar : PubMed/NCBI

133 

Chowdhury I, Mo Y, Gao L, Kazi A, Fisher AB and Feinstein SI: Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element. Free Radic Biol Med. 46:146–153. 2009. View Article : Google Scholar : PubMed/NCBI

134 

Fatma N, Kubo E, Takamura Y, Ishihara K, Garcia C, Beebe DC and Singh DP: Loss of NF-kappaB control and repression of Prdx6 gene transcription by reactive oxygen species-driven SMAD3-mediated transforming growth factor beta signaling. J Biol Chem. 284:22758–22772. 2009. View Article : Google Scholar : PubMed/NCBI

135 

Chhunchha B, Fatma N, Bhargavan B, Kubo E, Kumar A and Singh DP: Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress. Cell Death Dis. 2:e2342011. View Article : Google Scholar : PubMed/NCBI

136 

Wu X, Ji P, Zhang L, Bu G, Gu H, Wang X, Xiong Y and Zuo B: The expression of porcine Prdx6 gene is up-regulated by C/EBPβ and CREB. PLoS One. 10:e01448512015. View Article : Google Scholar : PubMed/NCBI

137 

Power JH, Asad S, Chataway TK, Chegini F, Manavis J, Temlett JA, Jensen PH, Blumbergs PC and Gai WP: Peroxiredoxin 6 in human brain: Molecular forms, cellular distribution, and association with Alzheimer's disease pathology. Acta Neuropathol. 115:611–622. 2008. View Article : Google Scholar : PubMed/NCBI

138 

Yun HM, Choi DY, Oh KW and Hong JT: PRDX6 exacerbates dopaminergic neurodegeneration in a MPTP mouse model of Parkinson's disease. Mol Neurobiol. 52:422–431. 2015. View Article : Google Scholar : PubMed/NCBI

139 

El Eter E, Al Masri A, Habib S, Al Zamil H, Al Hersi A, Al Hussein F and Al Omran M: Novel links among peroxiredoxins, endothelial dysfunction, and severity of atherosclerosis in type 2 diabetic patients with peripheral atherosclerotic disease. Cell Stress Chaperones. 19:173–181. 2014. View Article : Google Scholar

140 

Kubo E, Fatma N, Akagi Y, Beier DR, Singh SP and Singh DP: TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am J Physiol Cell Physiol. 294:C842–C855. 2008. View Article : Google Scholar : PubMed/NCBI

141 

Thongwatchara P, Promwikorn W, Srisomsap C, Chokchaichamnankit D, Boonyaphiphat P and Thongsuksai P: Differential protein expression in primary breast cancer and matched axillary node metastasis. Oncol Rep. 26:185–191. 2011.PubMed/NCBI

142 

Zhang J, Wang K, Zhang J, Liu SS, Dai L and Zhang JY: Using proteomic approach to identify tumor-associated proteins as biomarkers in human esophageal squamous cell carcinoma. J Proteome Res. 10:2863–2872. 2011. View Article : Google Scholar : PubMed/NCBI

143 

Schremmer B, Manevich Y, Feinstein SI and Fisher AB: Peroxiredoxins in the lung with emphasis on peroxiredoxin VI. Subcell Biochem. 44:317–344. 2007. View Article : Google Scholar : PubMed/NCBI

144 

Park JY, Kim SA, Chung JW, Bang S, Park SW, Paik YK and Song SY: Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer. J Cancer Res Clin Oncol. 137:1229–1238. 2011. View Article : Google Scholar : PubMed/NCBI

145 

Shukla S, Pranay A, D'Cruz AK, Chaturvedi P, Kane SV and Zingde SM: Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response. Cancer Biomark. 5:127–135. 2009.PubMed/NCBI

146 

Kuusisto ME, Haapasaari KM, Turpeenniemi-Hujanen T, Jantunen E, Soini Y, Peroja P, Bloigu R, Karihtala P and Kuittinen O: High intensity of cytoplasmic peroxiredoxin VI expression is associated with adverse outcome in diffuse large B-cell lymphoma independently of international prognostic index. J Clin Pathol. 68:552–556. 2015. View Article : Google Scholar : PubMed/NCBI

147 

Chang XZ, Li DQ, Hou YF, Wu J, Lu JS, Di GH, Jin W, Ou ZL, Shen ZZ and Shao ZM: Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer. Breast Cancer Res. 9:R762007. View Article : Google Scholar : PubMed/NCBI

148 

Raatikainen S, Aaaltomaa S, Kärjä V and Soini Y: Increased peroxiredoxin 6 expression predicts biochemical recurrence in prostate cancer patients after radical prostatectomy. Anticancer Res. 35:6465–6470. 2015.PubMed/NCBI

149 

Sofiadis A, Becker S, Hellman U, Hultin-Rosenberg L, Dinets A, Hulchiy M, Zedenius J, Wallin G, Foukakis T, Höög A, et al: Proteomic profiling of follicular and papillary thyroid tumors. Eur J Endocrinol. 166:657–667. 2012. View Article : Google Scholar : PubMed/NCBI

150 

Ho JN, Lee SB, Lee SS, Yoon SH, Kang GY, Hwang SG and Um HD: Phospholipase A2 activity of peroxiredoxin 6 promotes invasion and metastasis of lung cancer cells. Mol Cancer Ther. 9:825–832. 2010. View Article : Google Scholar : PubMed/NCBI

151 

Seibold P, Hall P, Schoof N, Nevanlinna H, Heikkinen T, Benner A, Liu J, Schmezer P, Popanda O, Flesch-Janys D and Chang-Claude J: Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients-potential differential effects by radiotherapy? Breast. 22:817–823. 2013. View Article : Google Scholar : PubMed/NCBI

152 

Glasauer A and Chandel NS: Targeting antioxidants for cancer therapy. Biochem Pharmacol. 92:90–101. 2014. View Article : Google Scholar : PubMed/NCBI

153 

Gorrini C, Harris IS and Mak TW: Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 12:931–947. 2013. View Article : Google Scholar : PubMed/NCBI

154 

Yang Y, Karakhanova S, Werner J and Bazhin AV: Reactive oxygen species in cancer biology and anticancer therapy. Curr Med Chem. 20:3677–3692. 2013. View Article : Google Scholar : PubMed/NCBI

155 

Wang T, Diaz AJ and Yen Y: The role of peroxiredoxin II in chemoresistance of breast cancer cells. Breast Cancer (Dove Med Press). 6:73–80. 2014.PubMed/NCBI

156 

Chung YM, Yoo YD, Park JK, Kim YT and Kim HJ: Increased expression of peroxiredoxin II confers resistance to cisplatin. Anticancer Res. 21:1129–1133. 2001.PubMed/NCBI

157 

Kalinina EV, Berezov TT, Shtil AA, Chernov NN, Glazunova VA, Novichkova MD and Nurmuradov NK: Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation. Bull Exp Biol Med. 153:878–881. 2012.(In English, Russian). View Article : Google Scholar : PubMed/NCBI

158 

Park SH, Chung YM, Lee YS, Kim HJ, Kim JS, Chae HZ and Yoo YD: Antisense of human peroxiredoxin II enhances radiation-induced cell death. Clin Cancer Res. 6:4915–4920. 2000.PubMed/NCBI

159 

Pak JH, Choi WH, Lee HM, Joo WD, Kim JH, Kim YT, Kim YM and Nam JH: Peroxiredoxin 6 overexpression attenuates cisplatin-induced apoptosis in human ovarian cancer cells. Cancer Invest. 29:21–28. 2011. View Article : Google Scholar : PubMed/NCBI

160 

Kwon T, Rho JK, Lee JC, Park YH, Shin HJ, Cho S, Kang YK, Kim BY, Yoon DY and Yu DY: An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib. Exp Mol Med. 47:e1652015. View Article : Google Scholar : PubMed/NCBI

161 

McDonald C, Muhlbauer J, Perlmutter G, Taparra K and Phelan SA: Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity. Int J Oncol. 45:219–226. 2014.PubMed/NCBI

162 

Song IS, Kim HK, Jeong SH, Lee SR, Kim N, Rhee BD, Ko KS and Han J: Mitochondrial peroxiredoxin III is a potential target for cancer therapy. Int J Mol Sci. 12:7163–7185. 2011. View Article : Google Scholar : PubMed/NCBI

163 

Li L and Yu AQ: The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells. J Cancer Res Clin Oncol. 141:2071–2077. 2015. View Article : Google Scholar : PubMed/NCBI

164 

Kropotov A, Gogvadze V, Shupliakov O, Tomilin N, Serikov VB, Tomilin NV and Zhivotovsky B: Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells. Exp Cell Res. 312:2806–2815. 2006. View Article : Google Scholar : PubMed/NCBI

165 

Butterfield LH, Merino A, Golub SH and Shau H: From cytoprotection to tumor suppression: The multifactorial role of peroxiredoxins. Antioxid Redox Signal. 1:385–402. 1999. View Article : Google Scholar : PubMed/NCBI

166 

Neumann CA and Fang Q: Are peroxiredoxins tumor suppressors? Curr Opin Pharmacol. 7:375–380. 2007. View Article : Google Scholar : PubMed/NCBI

167 

Woo HA, Jeong W, Chang TS, Park KJ, Park SJ, Yang JS and Rhee SG: Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins. J Biol Chem. 280:3125–3128. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nicolussi A, D'inzeo S, Capalbo C, Giannini G and Coppa A: The role of peroxiredoxins in cancer (Review). Mol Clin Oncol 6: 139-153, 2017.
APA
Nicolussi, A., D'inzeo, S., Capalbo, C., Giannini, G., & Coppa, A. (2017). The role of peroxiredoxins in cancer (Review). Molecular and Clinical Oncology, 6, 139-153. https://doi.org/10.3892/mco.2017.1129
MLA
Nicolussi, A., D'inzeo, S., Capalbo, C., Giannini, G., Coppa, A."The role of peroxiredoxins in cancer (Review)". Molecular and Clinical Oncology 6.2 (2017): 139-153.
Chicago
Nicolussi, A., D'inzeo, S., Capalbo, C., Giannini, G., Coppa, A."The role of peroxiredoxins in cancer (Review)". Molecular and Clinical Oncology 6, no. 2 (2017): 139-153. https://doi.org/10.3892/mco.2017.1129
Copy and paste a formatted citation
x
Spandidos Publications style
Nicolussi A, D'inzeo S, Capalbo C, Giannini G and Coppa A: The role of peroxiredoxins in cancer (Review). Mol Clin Oncol 6: 139-153, 2017.
APA
Nicolussi, A., D'inzeo, S., Capalbo, C., Giannini, G., & Coppa, A. (2017). The role of peroxiredoxins in cancer (Review). Molecular and Clinical Oncology, 6, 139-153. https://doi.org/10.3892/mco.2017.1129
MLA
Nicolussi, A., D'inzeo, S., Capalbo, C., Giannini, G., Coppa, A."The role of peroxiredoxins in cancer (Review)". Molecular and Clinical Oncology 6.2 (2017): 139-153.
Chicago
Nicolussi, A., D'inzeo, S., Capalbo, C., Giannini, G., Coppa, A."The role of peroxiredoxins in cancer (Review)". Molecular and Clinical Oncology 6, no. 2 (2017): 139-153. https://doi.org/10.3892/mco.2017.1129
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