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Article

Pilomatrix carcinoma: More malignant biological behavior than was considered in the past

  • Authors:
    • Marios Papadakis
    • Eelco de Bree
    • Nikolaos Floros
    • Elpida Giannikaki
    • Athina Xekalou
    • Andreas Manios
  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, Helios Clinic Wuppertal, University Hospital Witten-Herdecke, D-42283 Wuppertal, Germany, Department of Surgical Oncology, University Hospital of Crete, 71110 Heraklion, Greece, Department of Surgery, University Hospital Witten-Herdecke, D-42283 Wuppertal, Germany, Department of Pathology, General Hospital ‘Venizeleio and Pananio’, 71409 Heraklion, Greece
  • Pages: 415-418
    |
    Published online on: February 2, 2017
       https://doi.org/10.3892/mco.2017.1148
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Abstract

Pilomatrix carcinoma is a very rare malignancy, with ~130 cases reported in the literature. In the past, pilomatrix carcinoma was considered to be a low-grade malignant tumor. Currently, however, its significant recurrence and metastatic potential has been well documented. Lymph node and systemic metastases are frequently observed. Wide surgical excision of the primary lesion is the principal modality of treatment, whereas adjuvant radiotherapy may be beneficial in local tumor control. Lymph node metastases may be treated surgically or with radiotherapy. Systemic disease is not responsive to chemotherapy, and is hence associated with a poor prognosis. Since the majority of nodal and systemic metastases present after the initial diagnosis and treatment, follow-up examinations of these patients may be warranted, despite the currently inadequate treatment options. In the present study, a case of pilomatrix carcinoma of the parotid region with early local recurrence only 2 months after complete excision with negative surgical margins is reported. The local recurrence was treated by excision and radiotherapy. The associated literature is also discussed.
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1 

Malherbe A and Chenantais J: Sur l'epithelioma calcifie des glandes sebacees. Progr Med. 8:826–828. 1880.

2 

Dubreuilh W and Cazenave E: De l'epithelioma calcifie: Etude histologique. Ann Dermatol Syphilol. 3:257–268. 1922.

3 

Forbis R Jr and Helwig EB: Pilomatrixoma (calcifying epithelioma). Arch Dermatol. 83:606–618. 1961. View Article : Google Scholar : PubMed/NCBI

4 

Lopansri S and Mihm MC Jr: Pilomatrix carcinoma or calcifying epitheliocarcinoma of Malherbe: A case report and review of literature. Cancer. 45:2368–2373. 1980. View Article : Google Scholar : PubMed/NCBI

5 

Nishioka M, Tanemura A, Yamanaka T, Tani M, Miura H, Asakura M, Tamai N and Katayama I: Pilomatrix carcinoma arising from pilomatricoma after 10-year senescent period: Immunohistochemical analysis. J Dermatol. 37:735–739. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Sau P, Lupton GP and Graham JH: Pilomatrix carcinoma. Cancer. 71:2491–2498. 1993. View Article : Google Scholar : PubMed/NCBI

7 

Herrmann JL, Allan A, Trapp KM and Morgan MB: Pilomatrix carcinoma: 13 new cases and review of the literature with emphasis on predictors of metastasis. J Am Acad Dermatol. 71:38–43.e2. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Kaddu S, Soyer HP, Wolf IH and Kerl H: Proliferating pilomatricoma. A histopathologic simulator of matrical carcinoma. J Cutan Pathol. 24:228–234. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Tselis N, Heyd R, Vogt HG and Zamboglou N: Pilomatrix carcinoma with lymph node and pulmonary metastases. Strahlenther Onkol. 182:727–732. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Bassarova A, Nesland JM, Sedloev T, Danielsen H and Christova S: Pilomatrix carcinoma with lymph node metastases. J Cutan Pathol. 31:330–335. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Autelitano L, Biglioli F, Migliori G and Colletti G: Pilomatrix carcinoma with visceral metastases: Case report and review of the literature. J Plast Reconstr Aesthet Surg. 62:e574–e577. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Hardisson D, Linares MD, Cuevas-Santos J and Contreras F: Pilomatrix carcinoma: A clinicopathologic study of six cases and review of the literature. Am J Dermatopathol. 23:394–401. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Mikhaeel NG and Spittle MF: Malignant pilomatrixoma with multiple local recurrences and distant metastases: A case report and review of the literature. Clin Oncol (R Coll Radiol). 13:386–389. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Lan MY, Lan MC, Ho CY, Li WY and Lin CZ: Pilomatricoma of the head and neck: A retrospective review of 179 cases. Arch Otolaryngol Head Neck Surg. 129:1327–1330. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Manivel C, Wick MR and Mukai K: Pilomatrix carcinoma: An immunohistochemical comparison with benign pilomatrixoma and other benign cutaneous lesions of pilar origin. J Cutan Pathol. 13:22–29. 1986. View Article : Google Scholar : PubMed/NCBI

16 

Waxtein L, Vega E, Alvarez L, Cortes-Franco R, Hojyo T and Dominguez-Soto L: Malignant pilomatricoma: A case report. Int J Dermatol. 37:538–540. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Liu JF, Li B, Fan ZX, Jiao T, Li C, Qin S, Lang JY and Chen JX: Pilomatrix carcinoma on the left side of the parotid region: A case report and review of the literature. Oncol Lett. 10:313–316. 2015.PubMed/NCBI

18 

Jani P, Chetty R and Ghazarian DM: An unusual composite pilomatrix carcinoma with intralesional melanocytes: Differential diagnosis, immunohistochemical evaluation, and review of the literature. Am J Dermatopathol. 30:174–177. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Scheinfeld N: Pilomatrical carcinoma: A case in a patient with HIV and hepatitis C. Dermatol Online J. 14:42008.

20 

Kondo T and Tanaka Y: Malignant pilomatricoma in the parietal area. Pathol Oncol Res. 12:251–253. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Bhasker S, Bajpai V, Bahl A and Kalyanakuppam S: Recurrent pilomatrix carcinoma of scalp treated by electron beam radiation therapy. Indian J Cancer. 47:217–219. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Fujiwara T, Yamamoto H and Hashiro M: Malignant pilomatricoma. Scand J Plast Reconstr Surg Hand Surg. 36:119–121. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Sable D and Snow SN: Pilomatrix carcinoma of the back treated by mohs micrographic surgery. Dermatol Surg. 30:1174–1176. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Tawfiq N, Lakhrib N, Mharech A, Benchakroun N, Benider A, Benkirane A, Zamiati S, Mansouri I, Roubal M, Fatmi ME Kadiri, et al: Malignant pilomatrixoma of head and neck. A case report. Cancer Radiother. 14:198–201. 2010.(In French). View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Papadakis M, de Bree E, Floros N, Giannikaki E, Xekalou A and Manios A: Pilomatrix carcinoma: More malignant biological behavior than was considered in the past. Mol Clin Oncol 6: 415-418, 2017.
APA
Papadakis, M., de Bree, E., Floros, N., Giannikaki, E., Xekalou, A., & Manios, A. (2017). Pilomatrix carcinoma: More malignant biological behavior than was considered in the past. Molecular and Clinical Oncology, 6, 415-418. https://doi.org/10.3892/mco.2017.1148
MLA
Papadakis, M., de Bree, E., Floros, N., Giannikaki, E., Xekalou, A., Manios, A."Pilomatrix carcinoma: More malignant biological behavior than was considered in the past". Molecular and Clinical Oncology 6.3 (2017): 415-418.
Chicago
Papadakis, M., de Bree, E., Floros, N., Giannikaki, E., Xekalou, A., Manios, A."Pilomatrix carcinoma: More malignant biological behavior than was considered in the past". Molecular and Clinical Oncology 6, no. 3 (2017): 415-418. https://doi.org/10.3892/mco.2017.1148
Copy and paste a formatted citation
x
Spandidos Publications style
Papadakis M, de Bree E, Floros N, Giannikaki E, Xekalou A and Manios A: Pilomatrix carcinoma: More malignant biological behavior than was considered in the past. Mol Clin Oncol 6: 415-418, 2017.
APA
Papadakis, M., de Bree, E., Floros, N., Giannikaki, E., Xekalou, A., & Manios, A. (2017). Pilomatrix carcinoma: More malignant biological behavior than was considered in the past. Molecular and Clinical Oncology, 6, 415-418. https://doi.org/10.3892/mco.2017.1148
MLA
Papadakis, M., de Bree, E., Floros, N., Giannikaki, E., Xekalou, A., Manios, A."Pilomatrix carcinoma: More malignant biological behavior than was considered in the past". Molecular and Clinical Oncology 6.3 (2017): 415-418.
Chicago
Papadakis, M., de Bree, E., Floros, N., Giannikaki, E., Xekalou, A., Manios, A."Pilomatrix carcinoma: More malignant biological behavior than was considered in the past". Molecular and Clinical Oncology 6, no. 3 (2017): 415-418. https://doi.org/10.3892/mco.2017.1148
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