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Article

Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first‑line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis

  • Authors:
    • Javier Garde Noguera
    • Eloisa Jantus‑Lewintre
    • Mireia Gil‑Raga
    • Elena Evgenyeva
    • Sonia Maciá Escalante
    • Antonio Llombart‑Cussac
    • Carlos Camps Herrero
  • View Affiliations / Copyright

    Affiliations: Medical Oncology Department, Hospital Arnau de Vilanova of Valencia, 46015 Valencia, Spain, Molecular Oncology Laboratory, University General Hospital of Valencia, Research Foundation, 46014 Valencia, Spain, Medical Oncology Department, Hospital de Sagunto, 46520 Valencia, Spain, Pathology Department, Hospital Marina‑Salud de Denia, 03700 Dénia, Spain, Medical Oncology Department, Hospital General de Elda, 03600 Elda, Spain, Medical Oncology and Molecular Laboratory Department, University General Hospital of Valencia, University of Valencia, 46014 Valencia, Spain
  • Pages: 403-408
    |
    Published online on: February 3, 2017
       https://doi.org/10.3892/mco.2017.1149
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Abstract

The role of Kirsten rat sarcoma viral oncogene homolog (KRAS) and neuroblastoma RAS viral oncogene homolog (NRAS) mutations as negative predictors for anti‑epidermal growth factor receptor (EGFR) therapies in metastatic colorectal cancer (CRC) has been firmly established. However, whether the RAS mutation status plays a role as a biomarker for anti‑vascular endothelial growth factor (VEGF) treatment remains controversial. Data from 93 CRC patients who received first‑line cytotoxic chemotherapy with fluoropyrimidines and oxaliplatin, with or without bevacizumab, were analyzed. We investigated the association between the RAS mutation status and clinical outcomes in terms of response rate, progression-free survival (PFS) and overall survival (OS). Mutations in RAS genes were observed in 47 (52.6%) patients (45 KRAS and 2 NRAS mutations). Patients with tumours harbouring RAS mutations were less suitable for primary tumour resection, were more likely to develop lung metastases, and received bevacizumab treatment for a shorter time period compared with those with wild‑type tumours. The response rate to chemotherapy did not differ according to the RAS mutation status, and there were no significant differences in PFS [RAS mutation: 12 months, 95% confidence interval (CI): 8.7‑15.2 vs. RAS wild‑type: 12 months, 95% CI: 9.67‑14.32; P=0.857] or OS (RAS mutation: 20 months, 95% CI: 14.3‑25.6 vs. RAS wild‑type: 24 months, 95% CI: 18.7‑29.2; P=0.631). Patients with RAS mutation vs. those with RAS wild‑type exhibited a favourable trend in PFS when treated with bevacizumab (13 months, 95% CI: 6.5‑19.4 vs. 10 months, 95% CI: 4.2‑15.7, respectively; P=0.07) and OS (27 months, 95% CI: 18.5‑35.4 vs. 15 months, 95% CI: 12.4‑17.5, respectively; P=0.22). In conclusion, RAS mutations are not a prognostic marker for PFS and OS in CRC patients receiving fluoropyrimidine‑oxaliplatine treatment, with or without bevacizumab. RAS mutations are not predictive of the lack of efficacy of bevacizumab, and these patients appear to benefit from anti-angiogenic treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Garde Noguera J, Jantus‑Lewintre E, Gil‑Raga M, Evgenyeva E, Maciá Escalante S , Llombart‑Cussac A and Camps Herrero C: Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first‑line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis. Mol Clin Oncol 6: 403-408, 2017.
APA
Garde Noguera, J., Jantus‑Lewintre, E., Gil‑Raga, M., Evgenyeva, E., Maciá Escalante, S. ., Llombart‑Cussac, A., & Camps Herrero, C. (2017). Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first‑line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis. Molecular and Clinical Oncology, 6, 403-408. https://doi.org/10.3892/mco.2017.1149
MLA
Garde Noguera, J., Jantus‑Lewintre, E., Gil‑Raga, M., Evgenyeva, E., Maciá Escalante, S. ., Llombart‑Cussac, A., Camps Herrero, C."Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first‑line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis". Molecular and Clinical Oncology 6.3 (2017): 403-408.
Chicago
Garde Noguera, J., Jantus‑Lewintre, E., Gil‑Raga, M., Evgenyeva, E., Maciá Escalante, S. ., Llombart‑Cussac, A., Camps Herrero, C."Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first‑line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis". Molecular and Clinical Oncology 6, no. 3 (2017): 403-408. https://doi.org/10.3892/mco.2017.1149
Copy and paste a formatted citation
x
Spandidos Publications style
Garde Noguera J, Jantus‑Lewintre E, Gil‑Raga M, Evgenyeva E, Maciá Escalante S , Llombart‑Cussac A and Camps Herrero C: Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first‑line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis. Mol Clin Oncol 6: 403-408, 2017.
APA
Garde Noguera, J., Jantus‑Lewintre, E., Gil‑Raga, M., Evgenyeva, E., Maciá Escalante, S. ., Llombart‑Cussac, A., & Camps Herrero, C. (2017). Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first‑line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis. Molecular and Clinical Oncology, 6, 403-408. https://doi.org/10.3892/mco.2017.1149
MLA
Garde Noguera, J., Jantus‑Lewintre, E., Gil‑Raga, M., Evgenyeva, E., Maciá Escalante, S. ., Llombart‑Cussac, A., Camps Herrero, C."Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first‑line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis". Molecular and Clinical Oncology 6.3 (2017): 403-408.
Chicago
Garde Noguera, J., Jantus‑Lewintre, E., Gil‑Raga, M., Evgenyeva, E., Maciá Escalante, S. ., Llombart‑Cussac, A., Camps Herrero, C."Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first‑line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis". Molecular and Clinical Oncology 6, no. 3 (2017): 403-408. https://doi.org/10.3892/mco.2017.1149
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