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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

The significance of multi‑line chemotherapy for advanced gastric cancer: A retrospective analysis

  • Authors:
    • Meiqin Yuan
    • Zhong Shi
    • Zeng Wang
    • Wangxia Lv
    • Yunshan Yang
    • Fangxiao Lu
    • Yazhen Zhao
    • Haijun Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Radiology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 606-612
    |
    Published online on: February 10, 2017
       https://doi.org/10.3892/mco.2017.1163
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Abstract

Palliative chemotherapy is known to benefit patients with advanced gastric cancer by palliating symptoms and improving survival. The aim of the present study was to evaluate the efficacy and toxicity of chemotherapy regimens that are commonly used in patients with advanced or recurrent gastric cancer. Patients with advanced or recurrent gastric cancer who were treated by at least two chemotherapy regimens between May 2006 and July 2014 at Zhejiang Cancer Hospital (Hangzhou, China) were retrospectively investigated. Survival was evaluated using the Kaplan‑Meier method. A total of 248 patients were reviewed, and 158 were evaluated in the final analysis, with a median age of 57 years and a Karnofsky performance status score of ≥80. The median progression‑free survival (PFS) time was 168 days for first‑line chemotherapy, 96 days for second‑line chemotherapy, and the median overall survival (OS) time was 356 days. Further analysis revealed that patients with the disease controlled [complete response (CR) + partial response (PR) + stable disease (SD)], no matter whether they received first‑or second‑line chemotherapy, may have had an improved OS compared with patients with disease progression (PD). Patients who were treated with >2 lines of chemotherapy had an improved OS compared those who ceased treatment following failure of the second‑line chemotherapy. The cycle number of chemotherapy that patients received was associated with OS. The site of the primary and metastatic tumors was also associated with OS. Other factors, including gender, age, histological type, whether a radical operation was received, and chemotherapy regimens, had no evident association with survival. The toxicities were generally tolerated. Taken together, the results from the present study have demonstrated that an increased cycle number of effective chemotherapy may prolong the survival of patients with advanced gastric cancer. Differences among the chemotherapy regimens had no clear correlation with survival.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Tsai JY and Safran H: Status of treatment for advanced gastric carcinoma. Curr Oncol Rep. 5:210–218. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Power DG, Kelsen DP and Shah MA: Advanced gastric cancer slow but steady progress. Cancer Treat Rev. 36:384–392. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Wagner AD, Unverzagt S, Grothe W, Kleber G, Grothey A, Haerting J and Fleig WE: Chemotherapy for advanced gastric cancer. Cochrane Database Syst Rev. CD0040642010.PubMed/NCBI

5 

Sakuramoto S, Sasako M, Yamaguchi T, Kinoshita T, Fujii M, Nashimoto A, Furukawa H, Nakajima T, Ohashi Y, Imamura H, et al: ACTS-GC Group: Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med. 357:1810–1820. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, Miyashita K, Nishizaki T, Kobayashi O, Takiyama W, et al: S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): A phase III trial. Lancet Oncol. 9:215–221. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Boku N, Yamamoto S, Fukuda H, Shirao K, Doi T, Sawaki A, Koizumi W, Saito H, Yamaguchi K, Takiuchi H, et al: Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: A randomised phase 3 study. Lancet Oncol. 10:1063–1069. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Sato Y, Takayama T, Sagawa T, Takahashi Y, Ohnuma H, Okubo S, Shintani N, Tanaka S, Kida M, Sato Y, et al: Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer. Cancer Chemother Pharmacol. 66:721–728. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Yamaguchi H, Kitayama J, Ishigami H, Emoto S, Yamashita H and Watanabe T: A phase II trial of intravenous and intraperitoneal paclitaxel combined with S-1 for treatment of gastric cancer with macroscopic peritoneal metastasis. Cancer. 119:3354–3358. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Bang YJ, Kim YW, Yang HK, Chung HC, Park YK, Lee KH, Lee KW, Kim YH, Noh SI, Cho JY, et al: Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): A phase III open-label randomised controlled trial. Lancet. 379:315–321. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Oki E, Emi Y, Kusumoto T, Sakaguchi Y, Yamamoto M, Sadanaga N, Shimokawa M, Yamanaka T, Saeki H, Morita M, et al: Phase II study of docetaxel and S-1 (DS) as neoadjuvant chemotherapy for clinical stage III resectable gastric cancer. Ann Surg Oncol. 21:2340–2346. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomized controlled trial. Lancet. 376:687–697. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Thuss-Patience PC, Kretzschmar A, Bichev D, Deist T, Hinke A, Breithaupt K, Dogan Y, Gebauer B, Schumacher G and Reichardt P: Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer-a randomised phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Eur J Cancer. 47:2306–2314. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Kang JH, Lee SI, Lim do H, Park KW, Oh SY, Kwon HC, Hwang IG, Lee SC, Nam E, Shin DB, et al: Salvage chemotherapy for pretreated gastric cancer: A randomized phase III trial comparing chemotherapy plus best supportive care with best supportive care alone. J Clin Oncol. 30:1513–1518. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Kim HS, Kim HJ, Kim SY, Kim TY, Lee KW, Baek SK, Kim TY, Ryu MH, Nam BH and Zang DY: Second-line chemotherapy versus supportive cancer treatment in advanced gastric cancer: A meta-analysis. Ann Oncol. 24:2850–2854. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Shimizu T and Saijo N: Common toxicity criteria: Version 2.0, an improved reference for grading the adverse reaction of cancer treatment. Nihon Rinsho. 61:937–942. 2003.PubMed/NCBI

17 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Glimelius B, Hoffman K, Haglund U, Nyrén O and Sjödén PO: Initial or delayed chemotherapy with best supportive care in advanced gastric cancer. Ann Oncol. 5:189–190. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Pyrhönen S, Kuitunen T, Nyandoto P and Kouri M: Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer. Br J Cancer. 71:587–591. 1995. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yuan M, Shi Z, Wang Z, Lv W, Yang Y, Lu F, Zhao Y and Zhong H: The significance of multi‑line chemotherapy for advanced gastric cancer: A retrospective analysis. Mol Clin Oncol 6: 606-612, 2017.
APA
Yuan, M., Shi, Z., Wang, Z., Lv, W., Yang, Y., Lu, F. ... Zhong, H. (2017). The significance of multi‑line chemotherapy for advanced gastric cancer: A retrospective analysis. Molecular and Clinical Oncology, 6, 606-612. https://doi.org/10.3892/mco.2017.1163
MLA
Yuan, M., Shi, Z., Wang, Z., Lv, W., Yang, Y., Lu, F., Zhao, Y., Zhong, H."The significance of multi‑line chemotherapy for advanced gastric cancer: A retrospective analysis". Molecular and Clinical Oncology 6.4 (2017): 606-612.
Chicago
Yuan, M., Shi, Z., Wang, Z., Lv, W., Yang, Y., Lu, F., Zhao, Y., Zhong, H."The significance of multi‑line chemotherapy for advanced gastric cancer: A retrospective analysis". Molecular and Clinical Oncology 6, no. 4 (2017): 606-612. https://doi.org/10.3892/mco.2017.1163
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan M, Shi Z, Wang Z, Lv W, Yang Y, Lu F, Zhao Y and Zhong H: The significance of multi‑line chemotherapy for advanced gastric cancer: A retrospective analysis. Mol Clin Oncol 6: 606-612, 2017.
APA
Yuan, M., Shi, Z., Wang, Z., Lv, W., Yang, Y., Lu, F. ... Zhong, H. (2017). The significance of multi‑line chemotherapy for advanced gastric cancer: A retrospective analysis. Molecular and Clinical Oncology, 6, 606-612. https://doi.org/10.3892/mco.2017.1163
MLA
Yuan, M., Shi, Z., Wang, Z., Lv, W., Yang, Y., Lu, F., Zhao, Y., Zhong, H."The significance of multi‑line chemotherapy for advanced gastric cancer: A retrospective analysis". Molecular and Clinical Oncology 6.4 (2017): 606-612.
Chicago
Yuan, M., Shi, Z., Wang, Z., Lv, W., Yang, Y., Lu, F., Zhao, Y., Zhong, H."The significance of multi‑line chemotherapy for advanced gastric cancer: A retrospective analysis". Molecular and Clinical Oncology 6, no. 4 (2017): 606-612. https://doi.org/10.3892/mco.2017.1163
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