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Article

Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma

  • Authors:
    • Qun-Xiong Pan
    • Zi-Jian Su
    • Jian-Hua Zhang
    • Chong-Ren Wang
    • Shao-Ying Ke
  • View Affiliations / Copyright

    Affiliations: Department of Oncological Surgery, Quanzhou First Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China
  • Pages: 566-574
    |
    Published online on: February 16, 2017
       https://doi.org/10.3892/mco.2017.1166
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Abstract

High Glasgow Prognostic Score (GPS) has been associated with poor prognosis in patients with lung, ovarian, colorectal and renal cancer, as well as hepatocellular carcinoma. The aim of this study was to investigate the prognostic value of GPS in patients with intrahepatic cholangiocarcinoma (ICC) undergoing partial hepatectomy. A total of 72 patients with pathologically confirmed ICC were classified according to their GPS scores assigned based on the preoperative levels of C-reactive protein (CRP) and albumin. Their clinicopathological data were retrospectively assessed using univariate and multivariate analysis to determine their association with overall survival and recurrence. High GPS scores in ICC patients were associated with preoperative levels of CRP (P<0.001) and albumin (P<0.001), frequency of ascites accumulation (P=0.035), lymph node metastasis (P=0.002) and tumour size (P=0.005). On univariate analysis, preoperative levels of CRP (P<0.001), albumin (P=0.016) and carbohydrate antigen 19-9 (P=0.038), hepatitis B virus (HBV) positivity (P=0.009), occurrence of lymph node metastasis (P=0.001), Child-Pugh class B (P=0.013) and high tumour-node-metastasis (TNM) stage (P=0.002) were found to be associated with the 1- and 3-year overall survival. Multivariate analysis suggested that GPS score (HR=2.037, 95% CI: 1.092‑3.799, P=0.025), TNM classification (HR=2.000, 95% CI: 1.188-3.367, P=0.009) and HBV positivity (HR=0.559 95% CI: 0.328‑0.953, P=0.032) were independently associated with patient survival. High GPS scores also predicted ICC recurrence. In conclusion, our results demonstrated that GPS may serve as an independent marker of prognosis in patients with ICC following partial hepatectomy.
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1 

Guest RV, Boulter L, Kendall TJ, Minnis-Lyons SE, Walker R, Wigmore SJ, Sansom OJ and Forbes SJ: Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. Cancer Res. 74:1005–1010. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Nakanuma Y, Sripa B, Batanasapt V, Leong ASY, Ponchon T and Ishak KG: Intrahepatic cholangiocarcinoma. Pathology and Genetics of Tumours of the Digestive SystemWorld Health Organization of Tumours. Hamilton SR and Aaltonen LA: IARC; Lyon: pp. 173–180. 2000

3 

Farges O, Fuks D, Le Treut YP, et al: AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma:by the AFC-IHCC-2009 study group. Cancer. 117:2170–2177. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Zou S, Li J, Zhou H, Frech C, Jiang X, Chu JS, Zhao X, Li Y, Li Q, Wang H, et al: Mutational landscape of intrahepatic cholangiocarcinoma. Nat Commun. 5:56962014. View Article : Google Scholar : PubMed/NCBI

5 

Wang JD and Quan ZW: The molecular mechanism of cholangiocarcinoma. J Pract Oncol Chin. 22:96–98. 2007.

6 

de Jong MC, Nathan H, Sotiropoulos GC, Paul A, Alexandrescu S, Marques H, Pulitano C, Barroso E, Clary BM, Aldrighetti L, et al: Intrahepatic cholangiocarcinoma: An international multi-institutional analysis of prognostic factors and lymph node assessment. J Clin Oncol. 29:3140–3145. 2011. View Article : Google Scholar : PubMed/NCBI

7 

de Groen PC, Gores GJ, LaRusso NF, Gunderson LL and Nagorney DM: Biliary tract cancers. N Engl J Med. 341:1368–1378. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Li T, Qin LX, Zhou J, Sun HC, Qiu SJ, Ye QH, Wang L, Tang ZY and Fan J: Staging, prognostic factors and adjuvant therapy of intrahepatic cholangiocarcinoma after curative resection. Liver Int. 34:953–960. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Li H, Wu JS, Wang XT, Lv P, Gong LS, Liu G, Tian BN, Li YY and Jiang B: Factors predicting surgical resection in patients with intrahepatic cholangiocarcinoma and cirrhosis. J Invest Surg. 27:219–225. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Wang Y, Li J, Xia Y, Gong R, Wang K, Yan Z, Wan X, Liu G, Wu D, Shi L, et al: Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol. 31:1188–1195. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Paik KY, Jung JC, Heo JS, Choi SH, Choi DW and Kim YI: What prognostic factors are important for resected intrahepatic cholangiocarcinoma? J Gastroenterol Hepatol. 23:766–770. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K, Fushiya N, Koike K, Nishino H, Matsushima M, et al: The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma. BMC Cancer. 13:522013. View Article : Google Scholar : PubMed/NCBI

13 

Roxburgh CS and McMillan DC: Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol. 6:149–163. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Argilés JM, Busquets S, Toledo M and López-Soriano FJ: The role of cytokines in cancer cachexia. Curr Opin Support Palliat Care. 3:263–268. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Kusumanto YH, Dam WA, Hospers GA, Meijer C and Mulder NH: Platelets and granulocytes in particular the neutrophils from important compartments for circulating vascular endothelial growth factor. Angiogenesis. 6:283–287. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Ulich TR, Del Castillo J and Guo KZ: In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs. Blood. 73:108–110. 1989.PubMed/NCBI

18 

Philip M, Rowley DA and Schreiber H: Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol. 14:433–439. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Heikkilä KK, Ebrahim S and Lawlor DA: A systematic review of the association between circulating concentrations of C reactive protein and cancer. Epidemiol Community Health. 61:824–833. 2007. View Article : Google Scholar

20 

Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, et al: A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Res. 72:66–75. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Coward J, Kulbe H, Chakravarty P, Leader D, Vassileva V, Leinster DA, Thompson R, Schioppa T, Nemeth J, Vermeulen J, et al: Interleukin-6 as a therapeutic target in human ovarian cancer. Clin Cancer Res. 17:6083–6096. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Tomita M, Ayabe T, Chosa E and Nakamura K: Prognostic significance of pre- and postoperative glasgow prognostic score for patients with non-small cell lung cancer. Anticancer Res. 34:3137–3140. 2014.PubMed/NCBI

23 

Jiang AG, Chen HL and Lu HY: Comparison of Glasgow prognostic score and prognostic index in patients with advanced non-small cell lung cancer. J Cancer Res Clin Oncol. 141:563–568. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Sharma R, Hook J, Kumar M and Gabra H: Evaluation of an inflammation-based prognostic score in patients with advanced ovarian cancer. Eur J Cancer. 44:251–256. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Ikeguchi M, Urushibara S, Shimoda R, Yamamoto M, Maeta Y and Ashida K: Inflammation-based prognostic scores and nutritional prognostic index in patients with locally-advanced unresectable colorectal cancer. World J Surg Oncol. 12:2102014. View Article : Google Scholar : PubMed/NCBI

26 

Ramsey S, Lamb GW, Aitchison M, Graham J and McMillan DC: Evaluation of an inflammation-based prognostic score in patients with metastatic renal cancer. Cancer. 109:205–212. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Pan QX, Zhang JH, Su ZJ, Wang CR and Ke SY: The Glasgow Prognostic Score is an independent prognostic predictor of hepatocellular carcinoma following radical resection. Oncol Res Treat. 37:192–197. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Ishizuka M, Kubota K, Kita J, Shimoda M, Kato M and Sawada T: Impact of an inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma: A retrospective study of 398 Japanese patients. Am J Surg. 203:101–106. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Kaneko M, Nozawa H, Sasaki K, Hongo K, Hiyoshi M, Tada N, Murono K, Nirei T, Kawai K, Sunami E, et al: Elevated neutrophil to lymphocyte ratio predicts poor prognosis in advanced colorectal cancer patients receiving oxaliplatin-based chemotherapy. Oncology. 82:261–268. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Oh BS, Jang JW, Kwon JH, You CR, Chung KW, Kay CS, Jung HS and Lee S: Prognostic value of C-reactive protein and neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma. BMC Cancer. 13:782013. View Article : Google Scholar : PubMed/NCBI

31 

Kwon HC, Kim SH, Oh SY, Lee S, Lee JH, Choi HJ, Park KJ, Roh MS, Kim SG, Kim HJ, et al: Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers. 17:216–222. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Smith RA, Bosonnet L, Raraty M, Sutton R, Neoptolemos JP, Campbell F and Ghaneh P: Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma. Am J Surg. 197:466–472. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R and Small D: The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer. Curr Oncol. 17:52–58. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Proctor MJ, Morrison DS, Talwar D, Balmer SM, Fletcher CD, O'Reilly DS, Foulis AK, Horgan PG and McMillan DC: A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer. 47:2633–2641. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Pinato DJ, North BV and Sharma R: A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: The prognostic nutritional index (PNI). Br J Cancer. 106:1439–1445. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Gomez D, Morris-Stiff G, Toogood GJ, Lodge JP and Prasad KR: Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol. 97:513–518. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Oshiro Y, Sasaki R, Fukunaga K, Kondo T, Oda T, Takahashi H and Ohkohchi N: Inflammation-based prognostic score is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Sci. 20:389–395. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Hiraoka A, Kawamura T, Aibiki T, Okudaira T, Toshimori A, Yamago H, Nakahara H, Suga Y, Azemoto N, Miyata H, et al: Prognosis and therapy for ruptured hepatocellular carcinoma: Problems with staging and treatment strategy. Eur J Radiol. 84:366–371. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Edmondson HA and Steiner PE: Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies. Cancer. 7:462–503. 1954. View Article : Google Scholar : PubMed/NCBI

40 

Leyva-Illades D, McMillin M, Quinn M and Demorrow S: Cholangiocarcinoma pathogenesis: Role of the tumor microenvironment. Transl Gastrointest Cancer. 1:71–80. 2012.PubMed/NCBI

41 

Dutta S, Crumley AB, Fullarton GM, Horgan PG and McMillan DC: Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative resection of gastric cancer. Am J Surg. 204:294–299. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Wang DS, Ren C, Qiu MZ, Luo HY, Wang ZQ, Zhang DS, Wang FH, Li YH and Xu RH: Comparison of the prognostic value of various preoperative inflammation-based factors in patients with stage III gastric cancer. Tumour Biol. 33:749–756. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Glen P, Jamieson NB, McMillan DC, Carter R, Imrie CW and McKay CJ: Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer. Pancreatology. 6:450–453. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Allin KH and Nordestgaard BG: Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer. Crit Rev Clin Lab Sci. 48:155–170. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Johnson C, Han Y, Hughart N, McCarra J, Alpini G and Meng F: Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer. Transl Gastrointest Cancer. 1:58–70. 2012.PubMed/NCBI

46 

Wehbe H, Henson R, Meng F, Mize-Berge J and Patel T: Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression. Cancer Res. 66:10517–10524. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Park J, Tadlock L, Gores GJ and Patel T: Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line. Hepatology. 30:1128–1133. 1999. View Article : Google Scholar : PubMed/NCBI

48 

Meng F, Yamagiwa Y, Ueno Y and Patel T: Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes. J Hepatol. 44:1055–1065. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Heimbach JK, Gores GJ, Haddock MG, Alberts SR, Nyberg SL, Ishitani MB and Rosen CB: Liver transplantation for unresectable perihilar cholangiocarcinoma. Semin Liver Dis. 24:201–207. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Jarnagin WR, Fong Y, DeMatteo RP, Gonen M, Burke EC, BS J Bodniewicz, BA M Youssef, Klimstra D and Blumgart LH: Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg. 234:507–517, discussion 517–519. 2001. View Article : Google Scholar : PubMed/NCBI

51 

Yamada D, Rizvi S, Razumilava N, Bronk SF, Davila JI, Champion MD, Borad MJ, Bezerra JA, Chen X and Gores GJ: IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism. Hepatology. 61:1627–1642. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Jaiswal M, LaRusso NF, Burgart LJ and Gores GJ: Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res. 60:184–190. 2000.PubMed/NCBI

53 

Maemura K, Natsugoe S and Takao S: Molecular mechanism of cholangiocarcinoma carcinogenesis. J Hepatobiliary Pancreat Sci. 21:754–760. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Gupta D and Lis CG: Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature. Nutr J. 9:692010. View Article : Google Scholar : PubMed/NCBI

55 

Lien YC, Hsieh CC, Wu YC, Hsu HS, Hsu WH, Wang LS, Huang MH and Huang BS: Preoperative serum albumin level is a prognostic indicator for adenocarcinoma of the gastric cardia. J Gastrointest Surg. 8:1041–1048. 2004. View Article : Google Scholar : PubMed/NCBI

56 

McMillan DC, Watson WSO, O'Gorman P, Preston T, Scott HR and McArdle CS: Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss. Nutr Cancer. 39:210–213. 2001. View Article : Google Scholar : PubMed/NCBI

57 

Ohki S, Shibata M, Gonda K, Machida T, Shimura T, Nakamura I, Ohtake T, Koyama Y, Suzuki S, Ohto H, et al: Circulating myeloid-derived suppressor cells are increased and correlate to immune suppression, inflammation and hypoproteinemia in patients with cancer. Oncol Rep. 28:453–458. 2012.PubMed/NCBI

58 

Nakeeb A, Pitt HA, Sohn TA, Coleman J, Abrams RA, Piantadosi S, Hruban RH, Lillemoe KD, Yeo CJ and Cameron JL: Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg. 224:463–473, discussion 473–475. 1996. View Article : Google Scholar : PubMed/NCBI

59 

Tanaka M, Tanaka H, Tsukuma H, Ioka A, Oshima A and Nakahara T: Risk factors for intrahepatic cholangiocarcinoma: A possible role of hepatitis B virus. J Viral Hepat. 17:742–748. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Donato F, Gelatti U, Tagger A, Favret M, Ribero ML, Callea F, Martelli C, Savio A, Trevisi P and Nardi G: Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: A case-control study in Italy. Cancer Causes Control. 12:959–964. 2001. View Article : Google Scholar : PubMed/NCBI

61 

Wu Y, Wang T, Ye S, Zhao R, Bai X, Wu Y, Abe K and Jin X: Detection of hepatitis B virus DNA in paraffin-embedded intrahepatic and extrahepatic cholangiocarcinoma tissue in the northern Chinese population. Hum Pathol. 43:56–61. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Perumal V, Wang J, Thuluvath P, Choti M and Torbenson M: Hepatitis C and hepatitis B nucleic acids are present in intrahepatic cholangiocarcinomas from the United States. Hum Pathol. 37:1211–1216. 2006. View Article : Google Scholar : PubMed/NCBI

63 

Zhou Y, Zhao Y, Li B, Huang J, Wu L, Xu D, Yang J and He J: Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: Evidence from a meta-analysis. BMC Cancer. 12:2892012. View Article : Google Scholar : PubMed/NCBI

64 

Zhou HB, Wang H, Li YQ, Li SX, Wang H, Zhou DX, Tu QQ, Wang Q, Zou SS, Wu MC, et al: Hepatitis B virus infection: A favorable prognostic factor for intrahepatic cholangiocarcinoma after resection. World J Gastroenterol. 17:1292–1303. 2011. View Article : Google Scholar : PubMed/NCBI

65 

Zhang L, Cai JQ, Zhao JJ, Bi XY, Tan XG, Yan T, Li C and Zhao P: Impact of hepatitis B virus infection on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol. 101:233–238. 2010. View Article : Google Scholar : PubMed/NCBI

66 

Peng NF, Li LQ, Qin X, Guo Y, Peng T, Xiao KY, Chen XG, Yang YF, Su ZX, Chen B, et al: Evaluation of risk factors and clinicopathologic features for intrahepatic cholangiocarcinoma in Southern China: A possible role of hepatitis B virus. Ann Surg Oncol. 18:1258–1266. 2011. View Article : Google Scholar : PubMed/NCBI

67 

Zhou H, Wang H, Zhou D, Wang H, Wang Q, Zou S, Tu Q, Wu M and Hu H: Hepatitis B virus-associated intrahepatic cholangiocarcinoma and hepatocellular carcinoma may hold common disease process for carcinogenesis. Eur J Cancer. 46:1056–1061. 2010. View Article : Google Scholar : PubMed/NCBI

68 

Llovet JM, Brú C and Bruix J: Prognosis of hepatocellular carcinoma: The BCLC staging classification. Semin Liver Dis. 19:329–338. 1999. View Article : Google Scholar : PubMed/NCBI

69 

Ding FX, Wang F, Lu YM, Li K, Wang KH, He XW and Sun SH: Multiepitope peptide-loaded virus-like particles as a vaccine against hepatitis B virus-related hepatocellular carcinoma. Hepatology. 49:1492–1502. 2009. View Article : Google Scholar : PubMed/NCBI

70 

Ward SM, Phalora P, Bradshaw D, Leyendeckers H and Klenerman P: Direct ex vivo evaluation of long-lived protective antiviral memory B cell responses against hepatitis B virus. J Infect Dis. 198:813–817. 2008. View Article : Google Scholar : PubMed/NCBI

71 

No authors listed: A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators. Hepatology. 28:751–755. 1998. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pan Q, Su Z, Zhang J, Wang C and Ke S: Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma. Mol Clin Oncol 6: 566-574, 2017.
APA
Pan, Q., Su, Z., Zhang, J., Wang, C., & Ke, S. (2017). Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma. Molecular and Clinical Oncology, 6, 566-574. https://doi.org/10.3892/mco.2017.1166
MLA
Pan, Q., Su, Z., Zhang, J., Wang, C., Ke, S."Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma". Molecular and Clinical Oncology 6.4 (2017): 566-574.
Chicago
Pan, Q., Su, Z., Zhang, J., Wang, C., Ke, S."Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma". Molecular and Clinical Oncology 6, no. 4 (2017): 566-574. https://doi.org/10.3892/mco.2017.1166
Copy and paste a formatted citation
x
Spandidos Publications style
Pan Q, Su Z, Zhang J, Wang C and Ke S: Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma. Mol Clin Oncol 6: 566-574, 2017.
APA
Pan, Q., Su, Z., Zhang, J., Wang, C., & Ke, S. (2017). Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma. Molecular and Clinical Oncology, 6, 566-574. https://doi.org/10.3892/mco.2017.1166
MLA
Pan, Q., Su, Z., Zhang, J., Wang, C., Ke, S."Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma". Molecular and Clinical Oncology 6.4 (2017): 566-574.
Chicago
Pan, Q., Su, Z., Zhang, J., Wang, C., Ke, S."Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma". Molecular and Clinical Oncology 6, no. 4 (2017): 566-574. https://doi.org/10.3892/mco.2017.1166
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