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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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April-2017 Volume 6 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

Breast implant‑associated anaplastic large‑cell lymphoma and the role of brentuximab vedotin (SGN‑35) therapy: A case report and review of the literature

  • Authors:
    • Kristin Richardson
    • Taha Alrifai
    • Kelly Grant‑Szymanski
    • George J. Kouris
    • Parameswaran Venugopal
    • Brett Mahon
    • Reem Karmali
  • View Affiliations / Copyright

    Affiliations: Rush University Medical Center, Chicago, IL 60612, USA, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL 60612, USA, Department of Plastic and Reconstructive Surgery, Rush University Medical Center, Chicago, IL 60612, USA, Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA
  • Pages: 539-542
    |
    Published online on: February 17, 2017
       https://doi.org/10.3892/mco.2017.1170
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Abstract

Breast implant-associated (BIA) anaplastic large-cell lymphoma (ALCL) is a rare disease, comprising a small percentage of all non‑Hodgkin lymphomas (NHLs), reportedly 2‑3%. There is currently no established standard approach to the treatment of BIA ALCL. The first case on the development of ALCL in the presence of a breast implant was reported in 1997 and the association was first identified by the Food and Drug Administration in 2011. We herein describe a case of BIA ALCL in a patient with a previous history of breast cancer and breast reconstruction who presented with hardening of her breast implant. The patient underwent capsulectomy and the findings of the pathological examination were consistent with ALCL. The patient completed three cycles of combination chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP regimen) followed by radiation consolidation therapy, and has maintained a complete remission ever since. The aim of the present study was to review the treatment options for BIA ALCL and suggest an investigation of the CD30‑directed antibody‑drug conjugate, brentuximab vedotin, as a potential treatment option for BIA ALCL.
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Copy and paste a formatted citation
Spandidos Publications style
Richardson K, Alrifai T, Grant‑Szymanski K, Kouris GJ, Venugopal P, Mahon B and Karmali R: Breast implant‑associated anaplastic large‑cell lymphoma and the role of brentuximab vedotin (SGN‑35) therapy: A case report and review of the literature. Mol Clin Oncol 6: 539-542, 2017.
APA
Richardson, K., Alrifai, T., Grant‑Szymanski, K., Kouris, G.J., Venugopal, P., Mahon, B., & Karmali, R. (2017). Breast implant‑associated anaplastic large‑cell lymphoma and the role of brentuximab vedotin (SGN‑35) therapy: A case report and review of the literature. Molecular and Clinical Oncology, 6, 539-542. https://doi.org/10.3892/mco.2017.1170
MLA
Richardson, K., Alrifai, T., Grant‑Szymanski, K., Kouris, G. J., Venugopal, P., Mahon, B., Karmali, R."Breast implant‑associated anaplastic large‑cell lymphoma and the role of brentuximab vedotin (SGN‑35) therapy: A case report and review of the literature". Molecular and Clinical Oncology 6.4 (2017): 539-542.
Chicago
Richardson, K., Alrifai, T., Grant‑Szymanski, K., Kouris, G. J., Venugopal, P., Mahon, B., Karmali, R."Breast implant‑associated anaplastic large‑cell lymphoma and the role of brentuximab vedotin (SGN‑35) therapy: A case report and review of the literature". Molecular and Clinical Oncology 6, no. 4 (2017): 539-542. https://doi.org/10.3892/mco.2017.1170
Copy and paste a formatted citation
x
Spandidos Publications style
Richardson K, Alrifai T, Grant‑Szymanski K, Kouris GJ, Venugopal P, Mahon B and Karmali R: Breast implant‑associated anaplastic large‑cell lymphoma and the role of brentuximab vedotin (SGN‑35) therapy: A case report and review of the literature. Mol Clin Oncol 6: 539-542, 2017.
APA
Richardson, K., Alrifai, T., Grant‑Szymanski, K., Kouris, G.J., Venugopal, P., Mahon, B., & Karmali, R. (2017). Breast implant‑associated anaplastic large‑cell lymphoma and the role of brentuximab vedotin (SGN‑35) therapy: A case report and review of the literature. Molecular and Clinical Oncology, 6, 539-542. https://doi.org/10.3892/mco.2017.1170
MLA
Richardson, K., Alrifai, T., Grant‑Szymanski, K., Kouris, G. J., Venugopal, P., Mahon, B., Karmali, R."Breast implant‑associated anaplastic large‑cell lymphoma and the role of brentuximab vedotin (SGN‑35) therapy: A case report and review of the literature". Molecular and Clinical Oncology 6.4 (2017): 539-542.
Chicago
Richardson, K., Alrifai, T., Grant‑Szymanski, K., Kouris, G. J., Venugopal, P., Mahon, B., Karmali, R."Breast implant‑associated anaplastic large‑cell lymphoma and the role of brentuximab vedotin (SGN‑35) therapy: A case report and review of the literature". Molecular and Clinical Oncology 6, no. 4 (2017): 539-542. https://doi.org/10.3892/mco.2017.1170
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