Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report

Salerno,Sergio; Terranova,Maria Chiara; Rossello,Mario; Piccione,Maria; Ziino,Ottavio; Re,Giuseppe Lo

doi:10.3892/mco.2017.1171

April-2017 Volume 6 Issue 4

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April-2017 Volume 6 Issue 4

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Case Report

Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report

Authors:
- Sergio Salerno
- Maria Chiara Terranova
- Mario Rossello
- Maria Piccione
- Ottavio Ziino
- Giuseppe Lo Re
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Affiliations: Department of Radiology, University Hospital Paolo Giaccone, I-90127 Palermo, Italy, Department of Radiology, ‘Civico‑Di Cristina-Benfratelli’Municipal Hospital, I-90127 Palermo, Italy, Department of Pediatrics, Villa Sofia-Cervello Hospital, I-90146 Palermo, Italy, Department of Pediatric Oncology, ‘Civico‑Di Cristina-Benfratelli’ Municipal Hospital, I-90127 Palermo, Italy
Pages: 579-582
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Published online on: February 17, 2017

https://doi.org/10.3892/mco.2017.1171
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Abstract

Myofibromatosis is an uncommon disorder of infancy, characterized by proliferation of myofibroblasts in solitary or multiple nodules. The clinical characteristics depend on the involved sites: Myofibromatosis may develop as a musculoskeletal form, with non-painful swellings and eventual mass effect symptoms, or as a generalized form with visceral involvement and organ failure. Prognosis and therapy vary between the abovementioned patterns. When there is no visceral involvement, the tumors may regress spontaneously; however, the visceral form may represent a lifethreatening condition with poor outcome and it requires aggressive management. Imaging assessment of disease spread is mandatory to determine diagnosis, prognosis and therapy. Due to the young age of the patients, a radiation-free evaluation is recommended. We herein describe a case of musculoskeletal myofibromatosis diagnosed in a 3-month-old male infant, investigated by serial wholebody magnetic resonance imaging (MRI) examination. The histological analysis and MRI characteristics enabled a correct diagnosis and organ involvement assessment with no radiation exposure. Moreover, whole-body MRI sequences provided a detailed evaluation of the disease within a short time frame, reducing the time of sedation, which is required to perform MRI in very young patients. Therefore, whole-body MRI was found to be accurate and safe in the diagnosis and follow-up of multicentric infantile myofibromatosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report

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