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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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April-2017 Volume 6 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Case Report

Dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor T790M mutation: A case report

  • Authors:
    • Takehiro Uemura
    • Tetsuya Oguri
    • Minami Okayama
    • Hiromi Furuta
    • Yoshihiro Kanemitsu
    • Osamu Takakuwa
    • Hirotsugu Ohkubo
    • Masaya Takemura
    • Ken Maeno
    • Yutaka Ito
    • Akio Niimi
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan, Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan
  • Pages: 525-528
    |
    Published online on: March 3, 2017
       https://doi.org/10.3892/mco.2017.1181
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Abstract

We herein report a case of dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor (EGFR) T790M mutation encoded in exon 20. The patient was a 59-year-old woman with EGFR exon 19 deletion-positive lung adenocarcinoma, who relapsed with multiple brain metastases. Computed tomography‑guided biopsy of the left pleural tumor revealed adenocarcinoma harboring an EGFR exon 19 deletion and an EGFR T790M mutation encoded in exon 20. The patient was treated with osimertinib, a third-generation EGFR tyrosine kinase inhibitor. Two days after treatment initiation, the patient displayed profound disturbance of consciousness, possibly due to carcinomatous meningitis, and treatment had to be discontinued due to difficulty in taking osimertinib. However, the patient gradually started to recover consciousness and, after 3 days, she was again able to take osimertinib. One month after the initiation of osimertinib treatment, magnetic resonance imaging revealed an apparent reduction in brain metastases. The patient is currently under continued treatment with osimertinib. At the last follow‑up (February, 2017) she exhibited partial response to the treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Uemura T, Oguri T, Okayama M, Furuta H, Kanemitsu Y, Takakuwa O, Ohkubo H, Takemura M, Maeno K, Ito Y, Ito Y, et al: Dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor T790M mutation: A case report. Mol Clin Oncol 6: 525-528, 2017.
APA
Uemura, T., Oguri, T., Okayama, M., Furuta, H., Kanemitsu, Y., Takakuwa, O. ... Niimi, A. (2017). Dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor T790M mutation: A case report. Molecular and Clinical Oncology, 6, 525-528. https://doi.org/10.3892/mco.2017.1181
MLA
Uemura, T., Oguri, T., Okayama, M., Furuta, H., Kanemitsu, Y., Takakuwa, O., Ohkubo, H., Takemura, M., Maeno, K., Ito, Y., Niimi, A."Dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor T790M mutation: A case report". Molecular and Clinical Oncology 6.4 (2017): 525-528.
Chicago
Uemura, T., Oguri, T., Okayama, M., Furuta, H., Kanemitsu, Y., Takakuwa, O., Ohkubo, H., Takemura, M., Maeno, K., Ito, Y., Niimi, A."Dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor T790M mutation: A case report". Molecular and Clinical Oncology 6, no. 4 (2017): 525-528. https://doi.org/10.3892/mco.2017.1181
Copy and paste a formatted citation
x
Spandidos Publications style
Uemura T, Oguri T, Okayama M, Furuta H, Kanemitsu Y, Takakuwa O, Ohkubo H, Takemura M, Maeno K, Ito Y, Ito Y, et al: Dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor T790M mutation: A case report. Mol Clin Oncol 6: 525-528, 2017.
APA
Uemura, T., Oguri, T., Okayama, M., Furuta, H., Kanemitsu, Y., Takakuwa, O. ... Niimi, A. (2017). Dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor T790M mutation: A case report. Molecular and Clinical Oncology, 6, 525-528. https://doi.org/10.3892/mco.2017.1181
MLA
Uemura, T., Oguri, T., Okayama, M., Furuta, H., Kanemitsu, Y., Takakuwa, O., Ohkubo, H., Takemura, M., Maeno, K., Ito, Y., Niimi, A."Dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor T790M mutation: A case report". Molecular and Clinical Oncology 6.4 (2017): 525-528.
Chicago
Uemura, T., Oguri, T., Okayama, M., Furuta, H., Kanemitsu, Y., Takakuwa, O., Ohkubo, H., Takemura, M., Maeno, K., Ito, Y., Niimi, A."Dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor T790M mutation: A case report". Molecular and Clinical Oncology 6, no. 4 (2017): 525-528. https://doi.org/10.3892/mco.2017.1181
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