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Article

Log odds of positive lymph nodes is superior to the number‑ and ratio‑based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection

  • Authors:
    • Hong Yan Fang
    • Hui Yang
    • Zhong Shi He
    • Hong Zhao
    • Zhen Ming Fu
    • Fu Xiang Zhou
    • Yun Feng Zhou
  • View Affiliations / Copyright

    Affiliations: Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, Hubei 430071, P.R. China
  • Pages: 782-788
    |
    Published online on: March 22, 2017
       https://doi.org/10.3892/mco.2017.1203
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Abstract

The metastatic lymph node status (N classification) is an important prognostic factor for patients with colorectal cancer (CRC). The aim of the present study was to evaluate and compare the prognostic assessment of three different lymph node staging methods, namely standard lymph node (pN) staging, metastatic lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) in CRC patients who undergo curative resection (R0). Data were retrospectively collected from 192 patients who had undergone R0 resection. Kaplan‑Meier survival curves, Cox proportional hazards model and accuracy of the three methods (pN, LNR and LODDS) were compared to evaluate the prognostic effect. Univariate analysis demonstrated that pN, LNR and LODDS were all significantly correlated with survival (P=0.001, P<0.001 and P<0.001, respectively). The final result of the 3‑step multivariate analysis demonstrated that LODDS was superior to the other two N categories. Patients in the same pN or LNR classifications may be classified into different LODDS stages with different prognoses. Thus, LODDS may be a meaningful prognostic indicator and superior to the pN and LNR classifications in CRC patients who undergo curative (R0) resection.
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Copy and paste a formatted citation
Spandidos Publications style
Fang HY, Yang H, He ZS, Zhao H, Fu ZM, Zhou FX and Zhou YF: Log odds of positive lymph nodes is superior to the number‑ and ratio‑based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection. Mol Clin Oncol 6: 782-788, 2017.
APA
Fang, H.Y., Yang, H., He, Z.S., Zhao, H., Fu, Z.M., Zhou, F.X., & Zhou, Y.F. (2017). Log odds of positive lymph nodes is superior to the number‑ and ratio‑based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection. Molecular and Clinical Oncology, 6, 782-788. https://doi.org/10.3892/mco.2017.1203
MLA
Fang, H. Y., Yang, H., He, Z. S., Zhao, H., Fu, Z. M., Zhou, F. X., Zhou, Y. F."Log odds of positive lymph nodes is superior to the number‑ and ratio‑based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection". Molecular and Clinical Oncology 6.5 (2017): 782-788.
Chicago
Fang, H. Y., Yang, H., He, Z. S., Zhao, H., Fu, Z. M., Zhou, F. X., Zhou, Y. F."Log odds of positive lymph nodes is superior to the number‑ and ratio‑based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection". Molecular and Clinical Oncology 6, no. 5 (2017): 782-788. https://doi.org/10.3892/mco.2017.1203
Copy and paste a formatted citation
x
Spandidos Publications style
Fang HY, Yang H, He ZS, Zhao H, Fu ZM, Zhou FX and Zhou YF: Log odds of positive lymph nodes is superior to the number‑ and ratio‑based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection. Mol Clin Oncol 6: 782-788, 2017.
APA
Fang, H.Y., Yang, H., He, Z.S., Zhao, H., Fu, Z.M., Zhou, F.X., & Zhou, Y.F. (2017). Log odds of positive lymph nodes is superior to the number‑ and ratio‑based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection. Molecular and Clinical Oncology, 6, 782-788. https://doi.org/10.3892/mco.2017.1203
MLA
Fang, H. Y., Yang, H., He, Z. S., Zhao, H., Fu, Z. M., Zhou, F. X., Zhou, Y. F."Log odds of positive lymph nodes is superior to the number‑ and ratio‑based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection". Molecular and Clinical Oncology 6.5 (2017): 782-788.
Chicago
Fang, H. Y., Yang, H., He, Z. S., Zhao, H., Fu, Z. M., Zhou, F. X., Zhou, Y. F."Log odds of positive lymph nodes is superior to the number‑ and ratio‑based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection". Molecular and Clinical Oncology 6, no. 5 (2017): 782-788. https://doi.org/10.3892/mco.2017.1203
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