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Article Open Access

ECOG is as independent predictor of the response to chemotherapy, overall survival and progression-free survival in carcinoma of unknown primary site

  • Authors:
    • Rocío Grajales‑Álvarez
    • Ana Martin‑Aguilar
    • Juan A. Silva
    • Jaime G. de la Garza‑Salazar
    • Erika Ruiz‑García
    • César López‑Camarillo
    • Laurence A. Marchat
    • Horacio Astudillo‑de la Vega
  • View Affiliations / Copyright

    Affiliations: Oncology Hospital, National Medical Center, ‘Century XXI’, IMSS, México City 06720, Mexico, Clinic of Thoracic Oncology, National Institute of Cancerology, México City 14080, Mexico, Translational Medicine Laboratory, National Institute of Cancerology, México City 14080, Mexico, Oncogenomics Laboratory, Autonomous University of México City, México City 03100, Mexico, Molecular Biomedicine Program and Biotechnology Program, National School of Medicine and Homeopathy, Instituto Politecnico Nacional, México City 07320, Mexico, Translational Research Laboratory, Oncology Hospital, National Medical Center, ‘Century XXI’, IMSS, México City 06720, México
    Copyright: © Grajales‑Álvarez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 643-650
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    Published online on: April 6, 2017
       https://doi.org/10.3892/mco.2017.1209
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Abstract

The aim of the present study was to determine whether age, gender, functional status, histology, tumor location, number of metastases, and levels of the tumor markers, lactate dehydrogenase (LDH) and albumin, are poor prognostic factors for the response to chemotherapy in patients with carcinoma of unknown primary site. A total of 149 patients diagnosed with carcinoma of unknown primary site that was histologically confirmed, and treated with chemotherapy in the Oncology Hospital, National Medical Center, ‘Century XXI’ IMSS, Mexico City, Mexico during the period between January 2002 to December 2009, were carefully selected for the present study. The analysis of 149 patients diagnosed with carcinoma of unknown primary site revealed that the liver was the organ with the highest frequency of metastases (33.5%). The objective response rates to chemotherapy were ~30.2%. Notably, ECOG was an important predictor of response to chemotherapy (P=0.008). The median progression‑free survival was 7.1 months. Upon multivariate analysis, the Eastern Cooperative Oncology Group (ECOG) Scale of Performance Status was observed as an independent predictor of progression (P<0.0001). The median overall survival was 14.2 months. The ECOG was also an independent predictor of mortality (P<0.0001). In conclusion, the data from the present study have demonstrated that ECOG is an independent predictor of a poor response to chemotherapy, lower overall survival and progression‑free survival in carcinoma of unknown primary site.
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Copy and paste a formatted citation
Spandidos Publications style
Grajales‑Álvarez R, Martin‑Aguilar A, Silva JA, de la Garza‑Salazar JG, Ruiz‑García E, López‑Camarillo C, Marchat LA and Astudillo‑de la Vega H: ECOG is as independent predictor of the response to chemotherapy, overall survival and progression-free survival in carcinoma of unknown primary site. Mol Clin Oncol 6: 643-650, 2017.
APA
Grajales‑Álvarez, R., Martin‑Aguilar, A., Silva, J.A., de la Garza‑Salazar, J.G., Ruiz‑García, E., López‑Camarillo, C. ... Astudillo‑de la Vega, H. (2017). ECOG is as independent predictor of the response to chemotherapy, overall survival and progression-free survival in carcinoma of unknown primary site. Molecular and Clinical Oncology, 6, 643-650. https://doi.org/10.3892/mco.2017.1209
MLA
Grajales‑Álvarez, R., Martin‑Aguilar, A., Silva, J. A., de la Garza‑Salazar, J. G., Ruiz‑García, E., López‑Camarillo, C., Marchat, L. A., Astudillo‑de la Vega, H."ECOG is as independent predictor of the response to chemotherapy, overall survival and progression-free survival in carcinoma of unknown primary site". Molecular and Clinical Oncology 6.5 (2017): 643-650.
Chicago
Grajales‑Álvarez, R., Martin‑Aguilar, A., Silva, J. A., de la Garza‑Salazar, J. G., Ruiz‑García, E., López‑Camarillo, C., Marchat, L. A., Astudillo‑de la Vega, H."ECOG is as independent predictor of the response to chemotherapy, overall survival and progression-free survival in carcinoma of unknown primary site". Molecular and Clinical Oncology 6, no. 5 (2017): 643-650. https://doi.org/10.3892/mco.2017.1209
Copy and paste a formatted citation
x
Spandidos Publications style
Grajales‑Álvarez R, Martin‑Aguilar A, Silva JA, de la Garza‑Salazar JG, Ruiz‑García E, López‑Camarillo C, Marchat LA and Astudillo‑de la Vega H: ECOG is as independent predictor of the response to chemotherapy, overall survival and progression-free survival in carcinoma of unknown primary site. Mol Clin Oncol 6: 643-650, 2017.
APA
Grajales‑Álvarez, R., Martin‑Aguilar, A., Silva, J.A., de la Garza‑Salazar, J.G., Ruiz‑García, E., López‑Camarillo, C. ... Astudillo‑de la Vega, H. (2017). ECOG is as independent predictor of the response to chemotherapy, overall survival and progression-free survival in carcinoma of unknown primary site. Molecular and Clinical Oncology, 6, 643-650. https://doi.org/10.3892/mco.2017.1209
MLA
Grajales‑Álvarez, R., Martin‑Aguilar, A., Silva, J. A., de la Garza‑Salazar, J. G., Ruiz‑García, E., López‑Camarillo, C., Marchat, L. A., Astudillo‑de la Vega, H."ECOG is as independent predictor of the response to chemotherapy, overall survival and progression-free survival in carcinoma of unknown primary site". Molecular and Clinical Oncology 6.5 (2017): 643-650.
Chicago
Grajales‑Álvarez, R., Martin‑Aguilar, A., Silva, J. A., de la Garza‑Salazar, J. G., Ruiz‑García, E., López‑Camarillo, C., Marchat, L. A., Astudillo‑de la Vega, H."ECOG is as independent predictor of the response to chemotherapy, overall survival and progression-free survival in carcinoma of unknown primary site". Molecular and Clinical Oncology 6, no. 5 (2017): 643-650. https://doi.org/10.3892/mco.2017.1209
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