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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Case Report Open Access

Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report

  • Authors:
    • Iosune Baraibar
    • Almudena Quílez
    • Diego Salas
    • Marta Román
    • Christian Rolfo
    • José L. Pérez-Gracia
    • Ignacio Gil-Bazo
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain, Department of Radiology, Clínica Universidad de Navarra, Pamplona, Spain, Phase I - Early Clinical Trials Unit, Antwerp University Hospital, Edegem, Belgium
    Copyright: © Baraibar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 651-654
    |
    Published online on: April 6, 2017
       https://doi.org/10.3892/mco.2017.1210
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Abstract

The universal clinical use of multi-targeted tyrosine kinase inhibitors (TKIs) in patients diagnosed with advanced renal cell carcinoma (RCC) has significantly prolonged their estimated survival times and their quality of life. However, several adverse side-effects associated predominantly with the inhibition of the vascular endothelial growth factor receptor by these drugs may prove to be potentially life-threatening. One adverse event that is only rarely observed with the use of TKIs in this clinical setting is acute pancreatitis. In the present study, to the best of our knowledge, the first case of asymptomatic radiological acute pancreatitis associated with the use of pazopanib in monotherapy in a patient with RCC is presented. In addition, a comprehensive review of the literature on this topic is provided, and certain potential measures that may aid in early diagnosis and treatment are discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Baraibar I, Quílez A, Salas D, Román M, Rolfo C, Pérez-Gracia JL and Gil-Bazo I: Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report. Mol Clin Oncol 6: 651-654, 2017.
APA
Baraibar, I., Quílez, A., Salas, D., Román, M., Rolfo, C., Pérez-Gracia, J.L., & Gil-Bazo, I. (2017). Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report. Molecular and Clinical Oncology, 6, 651-654. https://doi.org/10.3892/mco.2017.1210
MLA
Baraibar, I., Quílez, A., Salas, D., Román, M., Rolfo, C., Pérez-Gracia, J. L., Gil-Bazo, I."Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report". Molecular and Clinical Oncology 6.5 (2017): 651-654.
Chicago
Baraibar, I., Quílez, A., Salas, D., Román, M., Rolfo, C., Pérez-Gracia, J. L., Gil-Bazo, I."Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report". Molecular and Clinical Oncology 6, no. 5 (2017): 651-654. https://doi.org/10.3892/mco.2017.1210
Copy and paste a formatted citation
x
Spandidos Publications style
Baraibar I, Quílez A, Salas D, Román M, Rolfo C, Pérez-Gracia JL and Gil-Bazo I: Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report. Mol Clin Oncol 6: 651-654, 2017.
APA
Baraibar, I., Quílez, A., Salas, D., Román, M., Rolfo, C., Pérez-Gracia, J.L., & Gil-Bazo, I. (2017). Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report. Molecular and Clinical Oncology, 6, 651-654. https://doi.org/10.3892/mco.2017.1210
MLA
Baraibar, I., Quílez, A., Salas, D., Román, M., Rolfo, C., Pérez-Gracia, J. L., Gil-Bazo, I."Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report". Molecular and Clinical Oncology 6.5 (2017): 651-654.
Chicago
Baraibar, I., Quílez, A., Salas, D., Román, M., Rolfo, C., Pérez-Gracia, J. L., Gil-Bazo, I."Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report". Molecular and Clinical Oncology 6, no. 5 (2017): 651-654. https://doi.org/10.3892/mco.2017.1210
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