Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study

Maruyama,Takayuki; Tomofuji,Takaaki; Machida,Tatsuya; Kato,Hironari; Tsutsumi,Koichiro; Uchida,Daisuke; Takaki,Akinobu; Yoneda,Toshiki; Miyai,Hisataka; Mizuno,Hirofumi; Ekuni,Daisuke; Okada,Hiroyuki; Morita,Manabu

doi:10.3892/mco.2017.1220

May-2017 Volume 6 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2017 Volume 6 Issue 5

Full Size Image

Article Open Access

Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study

Authors:
- Takayuki Maruyama
- Takaaki Tomofuji
- Tatsuya Machida
- Hironari Kato
- Koichiro Tsutsumi
- Daisuke Uchida
- Akinobu Takaki
- Toshiki Yoneda
- Hisataka Miyai
- Hirofumi Mizuno
- Daisuke Ekuni
- Hiroyuki Okada
- Manabu Morita
View Affiliations / Copyright

Affiliations: Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama 700‑8558, Japan, Department of Community Oral Health, Asahi University School of Dentistry, Mizuho, Gifu 501‑0296, Japan, Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan

Copyright: © Maruyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 683-687
|
Published online on: April 10, 2017

https://doi.org/10.3892/mco.2017.1220
Expand metrics +

Abstract

Several studies have indicated that periodontitis is a risk factor for cancer. However, the association between periodontitis and the prognosis of pancreatobiliary tract cancer remains unclear. The aim of this pilot study was to investigate the association between periodontitis and prognosis of pancreatobiliary tract cancer. A total of 22 patients diagnosed with pancreatobiliary tract cancer were analyzed. Oral health status, including severity of periodontitis, general health status and biochemical serum markers were evaluated. The Kaplan‑Meier method and Cox proportional hazards model were used to assess factors affecting the prognosis of pancreatobiliary tract cancer. The Kaplan-Meier analysis demonstrated that low body mass index, high concentration of serum C‑reactive protein (CRP) and severe periodontitis were significant prognostic factors for survival rate. The Cox proportional hazards model revealed that serum carbohydrate antigen 19‑9 concentration [hazard ratio (HR)=1.002; 95% confidence interval (CI): 1.000‑1.004] and serum CRP concentration (HR=2.57; 95% CI: 1.15‑5.74) were significantly associated with the prognosis of pancreatobiliary tract cancer. In addition, cancer patients with severe periodontitis had higher serum CRP concentrations compared with those without severe periodontitis. Therefore, severe periodontitis indirectly affected the prognosis of pancreatobiliary tract cancer through promoting systemic inflammation.

View Figures

View References

1	Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
2	Hundal R and Shaffer EA: Gallbladder cancer: Epidemiology and outcome. Clin Epidemiol. 6:99–109. 2014.PubMed/NCBI
3	American Cancer SocietyCancer Facts & Figures 2013. Atlanta: American Cancer Society; 2013
4	Adami HO and Trichopoulos D: Pancreatic cancerEkbom A and Trichopoulos D: Textbook of Cancer Epidemiology. 2nd. Oxford University Press; New York: pp. 333–348. 2008
5	Fitzpatrick SG and Katz J: The association between periodontal disease and cancer: A review of literature. J Dent. 38:83–95. 2010. View Article : Google Scholar : PubMed/NCBI
6	Joshipura KJ, Wand HC, Merchant AT and Rimm EB: Periodontal disease and biomarkers related to cardiovascular disease. J Dent Res. 83:151–155. 2004. View Article : Google Scholar : PubMed/NCBI
7	Loos BG: Systemic markers of inflammation in periodontitis. J Periodontol. 76:(11 Suppl). S2106–S2115. 2005. View Article : Google Scholar
8	Amabile N, Susini G, Pettenati-Soubayroux I, Bonello L, Gil JM, Argues S, Bonfil JJ and Paganelli F: Severity of periodontal disease correlates to inflammatory systemic status and independently predicts the presence and angiographic extent of stable coronary artery disease. J Intern Med. 263:644–652. 2008. View Article : Google Scholar : PubMed/NCBI
9	Roshani R, McCarthy F and Hagemann T: Inflammatory cytokines in human pancreatic cancer. Cancer Lett. 345:157–163. 2014. View Article : Google Scholar : PubMed/NCBI
10	Michaud DS, Joshipura K, Giovannucci E and Fuchs CS: A prospective study of periodontal disease and pancreatic cancer in US male health professionals. J Natl Cancer Inst. 99:171–175. 2007. View Article : Google Scholar : PubMed/NCBI
11	Chang JS, Tsai CR, Chen LT and Shan YS: Investigating the association between periodontal disease and risk of pancreatic cancer. Pancreas. 45:134–141. 2016. View Article : Google Scholar : PubMed/NCBI
12	Eke PI, Page RC, Wei L, Thornton-Evans G and Genco RJ: Update of the case definitions for population-based surveillance of periodontitis. J Periodontol. 83:1449–1454. 2012. View Article : Google Scholar : PubMed/NCBI
13	Le N, Sund M and Vinci A: GEMS collaborating group of Pancreas 2000: Prognostic and predictive markers in pancreatic adenocarcinoma. Dig Liver Dis. 48:223–230. 2016. View Article : Google Scholar : PubMed/NCBI
14	Pepys MB and Hirschfield GM: C-reactive protein: A critical update. J Clin Invest. 111:1805–1812. 2003. View Article : Google Scholar : PubMed/NCBI
15	Kishi T, Nakamura A, Itasaka S, Shibuya K, Matsumoto S, Kanai M, Kodama Y, Takaori K, Mizowaki T and Hiraoka M: Pretreatment C-reactive protein level predicts outcome and patterns of failure after chemodadiotherapy for locally advanced pancreatic cancer. Pancreatology. 15:694–700. 2015. View Article : Google Scholar : PubMed/NCBI
16	Paraskevas S, Huizinga JD and Loos BG: A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol. 35:277–290. 2008. View Article : Google Scholar : PubMed/NCBI
17	Winning L, Patterson CC, Cullen KM, Stevenson KA, Lundy FT, Kee F and Linden GJ: The association between subgingival periodontal pathogens and systemic inflammation. J Clin Periodontol. 42:799–806. 2015. View Article : Google Scholar : PubMed/NCBI
18	Siddiqui A, Heinzerling J, Livingston EH and Huerta S: Predictors of early mortality in veteran patients with pancreatic cancer. Am J Surg. 194:362–366. 2007. View Article : Google Scholar : PubMed/NCBI
19	Michaud DS, Izard J, Wilhelm-Benartzi CS, You DH, Grote VA, Tjønneland A, Dahm CC, Overvad K, Jenab M, Fedirko V, et al: Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut. 62:1764–1770. 2013. View Article : Google Scholar : PubMed/NCBI
20	Lackey NR and Wingate AL: The pilot study: One key to research successBrink PJ and Wood MJ: Advanced Design in Nursing Research. 2nd. Sage Publications; CA: 1998, View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study

This article is mentioned in:

Abstract

Figure 1

Related Articles