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Case Report

Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report

  • Authors:
    • Kenta Kawahara
    • Akimitsu Hiraki
    • Ryoji Yoshida
    • Hidetaka Arita
    • Yuichiro Matsuoka
    • Toshio Yamashita
    • Kan‑Ichi Koga
    • Masashi Nagata
    • Akiyuki Hirosue
    • Daiki Fukuma
    • Hideki Nakayama
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Sensory and Motor Organ Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 860‑8556, Japan, Division of Oral Oncology, Department of Oral and Maxillofacial Surgery, Fukuoka Dental College, Fukuoka 814‑0193, Japan, Department of Oral and Maxillofacial Surgery, Amakusa Central General Hospital, Amakusa, Kumamoto 863‑0033, Japan
  • Pages: 886-892
    |
    Published online on: April 21, 2017
       https://doi.org/10.3892/mco.2017.1226
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Abstract

Salivary duct carcinoma is a highly aggressive disease with a poor prognosis. Surgical resection is currently the only curative treatment, as there is no effective systemic therapy for this malignancy. Recently, trastuzumab has been shown to exhibit therapeutic efficacy in the treatment of salivary duct carcinoma; similarly, molecularly targeted agents, such as cetuximab, are expected to be useful for salivary duct carcinoma treatment. We herein describe the case of a 56-year-old man diagnosed with salivary duct carcinoma in the left submandibular region, with ipsilateral multiple metastases to the neck lymph nodes. Radical resection of the tumor and submandibular gland with neck dissection were performed. One month after radical surgery, computed tomography (CT) scans indicated metastasis in the lower lobe of the left lung. CT‑guided transthoracic fine‑needle aspiration biopsy revealed a single metastasis and lung metastasectomy was immediately performed. The tumor cells of the primary lesion and those of the lung metastasis were immunohistochemically positive for epidermal growth factor receptor. One month later, multiple right lung metastases appeared, and the patient was treated with cisplatin/5‑fluorouracil (5‑FU) chemotherapy plus cetuximab, achieving a complete radiographic response. However, multiple lung metastases developed during adjuvant weekly cetuximab monotherapy. Subsequently, treatment with S‑1 and weekly cetuximab was initiated, and the multiple lung metastases have been maintained as stable disease for 5 months. To the best of our knowledge, this is the first report of cetuximab use for the treatment of salivary duct carcinoma. Although cisplatin/5‑FU chemotherapy plus cetuximab was efficacious in treating the lung metastasis, cetuximab monotherapy was insufficient for controlling tumor growth.
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Copy and paste a formatted citation
Spandidos Publications style
Kawahara K, Hiraki A, Yoshida R, Arita H, Matsuoka Y, Yamashita T, Koga KI, Nagata M, Hirosue A, Fukuma D, Fukuma D, et al: Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report. Mol Clin Oncol 6: 886-892, 2017.
APA
Kawahara, K., Hiraki, A., Yoshida, R., Arita, H., Matsuoka, Y., Yamashita, T. ... Nakayama, H. (2017). Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report. Molecular and Clinical Oncology, 6, 886-892. https://doi.org/10.3892/mco.2017.1226
MLA
Kawahara, K., Hiraki, A., Yoshida, R., Arita, H., Matsuoka, Y., Yamashita, T., Koga, K., Nagata, M., Hirosue, A., Fukuma, D., Nakayama, H."Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report". Molecular and Clinical Oncology 6.6 (2017): 886-892.
Chicago
Kawahara, K., Hiraki, A., Yoshida, R., Arita, H., Matsuoka, Y., Yamashita, T., Koga, K., Nagata, M., Hirosue, A., Fukuma, D., Nakayama, H."Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report". Molecular and Clinical Oncology 6, no. 6 (2017): 886-892. https://doi.org/10.3892/mco.2017.1226
Copy and paste a formatted citation
x
Spandidos Publications style
Kawahara K, Hiraki A, Yoshida R, Arita H, Matsuoka Y, Yamashita T, Koga KI, Nagata M, Hirosue A, Fukuma D, Fukuma D, et al: Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report. Mol Clin Oncol 6: 886-892, 2017.
APA
Kawahara, K., Hiraki, A., Yoshida, R., Arita, H., Matsuoka, Y., Yamashita, T. ... Nakayama, H. (2017). Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report. Molecular and Clinical Oncology, 6, 886-892. https://doi.org/10.3892/mco.2017.1226
MLA
Kawahara, K., Hiraki, A., Yoshida, R., Arita, H., Matsuoka, Y., Yamashita, T., Koga, K., Nagata, M., Hirosue, A., Fukuma, D., Nakayama, H."Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report". Molecular and Clinical Oncology 6.6 (2017): 886-892.
Chicago
Kawahara, K., Hiraki, A., Yoshida, R., Arita, H., Matsuoka, Y., Yamashita, T., Koga, K., Nagata, M., Hirosue, A., Fukuma, D., Nakayama, H."Salivary duct carcinoma treated with cetuximab-based targeted therapy: A case report". Molecular and Clinical Oncology 6, no. 6 (2017): 886-892. https://doi.org/10.3892/mco.2017.1226
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