Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
June-2017 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2017 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy

  • Authors:
    • Carsten Nieder
    • Bård Mannsåker
    • Astrid Dalhaug
    • Adam Pawinski
    • Ellinor Haukland
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Arctic University of Norway, N-9037 Tromsø, Norway, Department of Oncology and Palliative Medicine, Nordland Hospital, N-8092 Bodø, Norway
    Copyright: © Nieder et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 811-816
    |
    Published online on: April 26, 2017
       https://doi.org/10.3892/mco.2017.1228
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of the present retrospective study was to investigate whether a score reflecting systemic inflammatory processes [the Glasgow Prognostic Score (GPS)] provides relevant information for radiation oncologists. GPS is a three‑tiered score [0: normal C-reactive protein (CRP) and albumin; 1: one abnormal result; 2: increased CRP and low albumin]. Correlations between disease type and extent, resource utilization, survival and GPS were analyzed in 703 patients. In the subgroup with GPS 2, significantly higher rates of lung, adrenal gland and liver metastases were observed. An increasing GPS score was associated with a higher likelihood of anemia, leukocytosis and thrombocytosis. Comparable findings were made regarding utilization of palliative care resources, need for blood transfusion and intravenous administration of antibiotics. Compared with GPS 0 or 1, more patients with GPS 2 did not complete their prescribed course of radiotherapy. One-third of patients with GPS 2 received treatment during the final month of life. Multivariate analysis demonstrated that GPS was a significant prognostic factor for overall survival (median, 479, 136, and 61 days, for GPS 0, 1 and 2, respectively). In patients with GPS 2 and additional leukocytosis, the median survival was 38 days. In conclusion, GPS provides important prognostic information. This biomarker-based score may be considered for deciding fractionation, and should be validated further.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Tseng YD, Krishnan MS, Sullivan AJ, Jones JA, Chow E and Balboni TA: How radiation oncologists evaluate and incorporate life expectancy estimates into the treatment of palliative cancer patients: A survey-based study. Int J Radiat Oncol Biol Phys. 87:471–478. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Likhacheva A, Pinnix CC, Parikh NR, Allen PK, McAleer MF, Chiu MS, Sulman EP, Mahajan A, Guha-Thakurta N, Prabhu SS, et al: Predictors of survival in contemporary practice after initial radiosurgery for brain metastases. Int J Radiat Oncol Biol Phys. 85:656–661. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Forrest LM, McMillan DC, McArdle CS, Angerson WJ and Dunlop DJ: Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer. Br J Cancer. 90:1704–1706. 2004.PubMed/NCBI

4 

Proctor MJ, Morrison DS, Talwar D, Balmer SM, O'Reilly DS, Foulis AK, Horgan PG and McMillan DC: An inflammation-based prognostic score (mGPS) predicts cancer survival independent of tumour site: A Glasgow Inflammation Outcome Study. Br J Cancer. 104:726–734. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Proctor MJ, Morrison DS, Talwar D, Balmer SM, Fletcher CD, O'Reilly DS, Foulis AK, Horgan PG and McMillan DC: A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer. 47:2633–2641. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Linton A, Pond G, Clarke S, Vardy J, Galsky M and Sonpavde G: Glasgow prognostic score as a prognostic factor in metastatic castration-resistant prostate cancer treated with docetaxel-based chemotherapy. Clin Genitourin Cancer. 11:423–430. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Guadagnolo BA, Liao KP, Elting L, Giordano S, Buchholz TA and Shih YC: Use of radiation therapy in the last 30 days of life among a large population-based cohort of elderly patients in the United States. J Clin Oncol. 31:80–87. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Murphy JD, Nelson LM, Chang DT, Mell LK and Le QT: Patterns of care in palliative radiotherapy: A population-based study. J Oncol Pract. 9:e220–e227. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Kapadia NS, Mamet R, Zornosa C, Niland JC, D'Amico TA and Hayman JA: Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer. Cancer. 118:4339–4345. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Kelly CM and Shahrokni A: Moving beyond Karnofsky and ECOG performance status assessments with new technologies. J Oncol. 2016:61865432016. View Article : Google Scholar : PubMed/NCBI

11 

Hahn C, Kavanagh B, Bhatnagar A, Jacobson G, Lutz S, Patton C, Potters L and Steinberg M: Choosing wisely: The American Society for Radiation Oncology's top 5 list. Pract Radiat Oncol. 4:349–355. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Olson RA, Tiwana MS, Barnes M, Kiraly A, Beecham K, Miller S, Hoegler D and Olivotto I: Use of single- versus multiple-fraction palliative radiation therapy for bone metastases: Population-based analysis of 16,898 courses in a Canadian province. Int J Radiat Oncol Biol Phys. 89:1092–1099. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Sperduto PW, Chao ST, Sneed PK, Luo X, Suh J, Roberge D, Bhatt A, Jensen AW, Brown PD, Shih H, et al: Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: A multi-institutional analysis of 4,259 patients. Int J Radiat Oncol Biol Phys. 77:655–661. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Gaspar L, Scott C, Rotman M, Asbell S, Phillips T, Wasserman T, McKenna WG and Byhardt R: Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys. 37:745–751. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Partl R, Richtig E, Avian A, Berghold A and Kapp KS: Karnofsky performance status and lactate dehydrogenase predict the benefit of palliative whole-brain irradiation in patients with advanced intra- and extracranial metastases from malignant melanoma. Int J Radiat Oncol Biol Phys. 85:662–666. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Tan CS, Read JA, Phan VH, Beale PJ, Peat JK and Clarke SJ: The relationship between nutritional status, inflammatory markers and survival in patients with advanced cancer: A prospective cohort study. Support Care Cancer. 23:385–391. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Anshushaug M, Gynnild MA, Kaasa S, et al: Characterization of patients receiving palliative chemo- and radiotherapy during end of life at a regional cancer center in Norway. Acta Oncol. 27:1–8. 2014.

18 

Leung EY, Scott HR and McMillan DC: Clinical utility of the pretreatment glasgow prognostic score in patients with advanced inoperable non-small cell lung cancer. J Thorac Oncol. 7:655–662. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Laird BJ, Kaasa S, McMillan DC, Fallon MT, Hjermstad MJ, Fayers P and Klepstad P: Prognostic factors in patients with advanced cancer: A comparison of clinicopathological factors and the development of an inflammation-based prognostic system. Clin Cancer Res. 19:5456–5464. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Furukawa K, Shiba H, Haruki K, Fujiwara Y, Iida T, Mitsuyama Y, Ogawa M, Ishida Y, Misawa T and Yanaga K: The Glasgow prognostic score is valuable for colorectal cancer with both synchronous and metachronous unresectable liver metastases. Oncol Lett. 4:324–328. 2012.PubMed/NCBI

21 

Gioulbasanis I, Pallis A, Vlachostergios PJ, Xyrafas A, Giannousi Z, Perdikouri IE, Makridou M, Kakalou D and Georgoulias V: The Glasgow Prognostic Score (GPS) predicts toxicity and efficacy in platinum-based treated patients with metastatic lung cancer. Lung Cancer. 77:383–388. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Angelo K, Norum J, Dalhaug A, Pawinski A, Aandahl G, Haukland E, Engljähringer K and Nieder C: Development and validation of a model predicting short survival (death within 30 days) after palliative radiotherapy. Anticancer Res. 34:877–885. 2014.PubMed/NCBI

23 

Gripp S, Mjartan S, Boelke E and Willers R: Palliative radiotherapy tailored to life expectancy in end-stage cancer patients: Reality or myth? Cancer. 116:3251–3256. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Nieder C, Angelo K, Dalhaug A, Pawinski A, Haukland E and Norum J: Palliative radiotherapy during the last month of life: Predictability for referring physicians and radiation oncologists. Oncol Lett. 10:3043–3049. 2015.PubMed/NCBI

25 

Proctor MJ, Horgan PG, Talwar D, Fletcher CD, Morrison DS and McMillan DC: Optimization of the systemic inflammation-based Glasgow prognostic score: A Glasgow Inflammation Outcome Study. Cancer. 119:2325–2332. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nieder C, Mannsåker B, Dalhaug A, Pawinski A and Haukland E: The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy. Mol Clin Oncol 6: 811-816, 2017.
APA
Nieder, C., Mannsåker, B., Dalhaug, A., Pawinski, A., & Haukland, E. (2017). The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy. Molecular and Clinical Oncology, 6, 811-816. https://doi.org/10.3892/mco.2017.1228
MLA
Nieder, C., Mannsåker, B., Dalhaug, A., Pawinski, A., Haukland, E."The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy". Molecular and Clinical Oncology 6.6 (2017): 811-816.
Chicago
Nieder, C., Mannsåker, B., Dalhaug, A., Pawinski, A., Haukland, E."The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy". Molecular and Clinical Oncology 6, no. 6 (2017): 811-816. https://doi.org/10.3892/mco.2017.1228
Copy and paste a formatted citation
x
Spandidos Publications style
Nieder C, Mannsåker B, Dalhaug A, Pawinski A and Haukland E: The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy. Mol Clin Oncol 6: 811-816, 2017.
APA
Nieder, C., Mannsåker, B., Dalhaug, A., Pawinski, A., & Haukland, E. (2017). The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy. Molecular and Clinical Oncology, 6, 811-816. https://doi.org/10.3892/mco.2017.1228
MLA
Nieder, C., Mannsåker, B., Dalhaug, A., Pawinski, A., Haukland, E."The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy". Molecular and Clinical Oncology 6.6 (2017): 811-816.
Chicago
Nieder, C., Mannsåker, B., Dalhaug, A., Pawinski, A., Haukland, E."The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy". Molecular and Clinical Oncology 6, no. 6 (2017): 811-816. https://doi.org/10.3892/mco.2017.1228
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team