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Molecular and Clinical Oncology
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Case Report

Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature

  • Authors:
    • Aya Kobayashi
    • Tamaki Yahata
    • Sakiko Nanjo
    • Mika Mizoguchi
    • Madoka Yamamoto
    • Yasushi Mabuchi
    • Shigetaka Yagi
    • Sawako Minami
    • Kazuhiko Ino
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama 641‑8509, Japan
  • Pages: 881-885
    |
    Published online on: April 27, 2017
       https://doi.org/10.3892/mco.2017.1229
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Abstract

Large-cell neuroendocrine carcinoma (LCNEC) is a high‑grade neuroendocrine tumor. LCNECs arising from the genital organs are highly malignant and rare, with <20 cases of LCNEC developing from the uterine endometrium reported to date. We herein present the case of a patient with LCNEC of the endometrium. The patient was a 52‑year‑old woman, who exhibited lower abdominal pain and rapid uterine enlargement during outpatient treatment for uterine myoma. The endometrial biopsy suggested a diagnosis of poorly differentiated carcinoma or carcinosarcoma. Based on magnetic resonance imaging and positron emission tomography/computed tomography, endometrial stromal sarcoma was suspected. The serum lactate dehydrogenase level was abnormally high. Due to the suspicion of stage IIIC malignant tumor of the uterine corpus, surgery was performed. The pathological diagnosis was stage IIIC2 LCNEC of the endometrium. Recurrence occurred in the vaginal stump, and concurrent chemoradiotherapy (CCRT) was initiated 1 month after the surgery. The residual lesions markedly shrank, but metastasis to the upper abdominal region and cervix subsequently developed. CCRT was attempted, but the associated adverse effects were severe and was switched to palliative treatment. The patient eventually succumbed to the disease 309 days after surgery.
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1 

Bosman FT, Carneiro F, Hruban RH and Theise ND: Nomenclature and classification of neuroendocrine neoplasma of the digestive systemWHO Classification of Tumours of the Digestive System. 4th. Lyon: IARC; pp. 13–14. 2010;

2 

Kurman RJ, Carcangiu ML, Herrington CS and Young RH: WHO Classification of Tumours of Female Reproductive Organs. 4th. Lyon: IARC; pp. 1222014

3 

Mulvany NJ and Allen DG: Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium. Int J Gynecol Pathol. 27:49–57. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Albores-Saavedra J, Martinez-Benitez B and Luevano E: Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: Polypoid tumors and those arising in polyps may have a favorable prognosis. Int J Gynecol Pathol. 27:333–339. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Terada T: Large cell neuroendocrine carcinoma with sarcomatous changes of the endometrium: A case report with immunohistochemical studies and molecular genetic study of KIT and PDGFRA. Pathol Res Pract. 206:420–425. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Matsumoto H, Nasu K, Kai K, Nishida M, Narahara H and Nishida H: Combined large-cell neuroendocrine carcinoma and endometrioid adenocarcinoma of the endometrium: A case report and survey of related literature. J Obstet Gynaecol Res. 42:206–210. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Erhan Y, Dikmen Y, Yucebilgin MS, Zekioglu O, Mgoyi L and Terek MC: Large cell neuroendocrine carcinoma of the uterine corpus metastatic to brain and lung: Case report and review of the literature. Eur J Gynaecol Oncol. 25:109–112. 2004.PubMed/NCBI

8 

Nguyen ML, Han L, Minors AM, Bentley-Hibbert S, Pradhan TS, Pua TL and Tedjarati SS: Rare large cell neuroendocrine tumor of the endometrium: A case report and review of the literature. Int J Surg Case Rep. 4:651–655. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Makihara N, Maeda T, Nishimura M, Deguchi M, Sonoyama A, Nakabayashi K, Kawakami F, Itoh T and Yamada H: Large cell neuroendocrine carcinoma originating from the uterine endometrium: A report on magnetic resonance features of 2 cases with very rare and aggressive tumor. Rare Tumors. 4:e372012. View Article : Google Scholar : PubMed/NCBI

10 

Shahabi S, Pellicciotta I, Hou J, Graceffa S, Huang GS, Samuelson RN and Goldberg GL: Clinical utility of chromogranin A and octreotide in large cell neuro endocrine carcinoma of the uterine corpus. Rare Tumors. 3:e412011. View Article : Google Scholar : PubMed/NCBI

11 

Posligua L, Malpica A, Liu J, Brown J and Deavers MT: Combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium with pagetoid spread. Arch Pathol Lab Med. 132:1821–1824. 2008.PubMed/NCBI

12 

Deodhar KK, Kerkar RA, Suryawanshi P, Menon H and Menon S: Large cell neuroendocrine carcinoma of the endometrium: An extremely uncommon diagnosis, but worth the efforts. J Cancer Res Ther. 7:211–213. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Travis WD, Brambilla E, Burke AP, Marx A and Nicholson AG: Large cell neuroendocrine carcinomaWHO Classification of Tumours of Lung, Pleura, Thymus and Heart. 4th. Lyon: IARC; pp. 69–72. 2015

14 

Tsukamoto N: The general rules for clinical and pathological management of uterine corpus cancer. Nihon Rinsho. 10:285–289. 2004.(In Japanese).

15 

Gilks CB, Young RH, Gersell DJ and Clement PB: Large cell neuroendocrine [corrected] carcinoma of the uterine cervix: A clinicopathologic study of 12 cases. Am J Surg Pathol. 21:905–914. 1997. View Article : Google Scholar : PubMed/NCBI

16 

McCluggage WG, Kennedy K and Busam KJ: An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63. Am J Surg Pathol. 34:525–532. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Krivak TC, McBroom JW, Sundborg MJ, Crothers B and Parker MF: Large cell neuroendocrine cervical carcinoma: A report of two cases and review of the literature. Gynecol Oncol. 82:187–191. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Sato Y, Shimamoto T, Amada S, Asada Y and Hayashi T: Large cell neuroendocrine carcinoma of the uterine cervix: A clinicopathological study of six cases. Int J Gynecol Pathol. 22:226–230. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Tanimoto H, Hamasaki A, Akimoto Y, Honda H, Takao Y, Okamoto K, Teramoto M, Teramoto H, Kaneko M and Oshita T: A case of large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix successfully treated by postoperative CPT-11+CDDP chemotherapy after non-curative surgery. Gan To Kagaku Ryoho. 39:1439–1441. 2012.(In Japanese). PubMed/NCBI

20 

Noda K, Nishiwaki Y, Kawahara M, Negoro S, Sugiura T, Yokoyama A, Fukuoka M, Mori K, Watanabe K and Tamura T: Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med. 346:85–91. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Scully RE, Aguirre P and DeLellis RA: Argyrophilia, serotonin, and peptide hormones in the female genital tract and its tumors. Int J Gynecol Pathol. 3:51–70. 1984. View Article : Google Scholar : PubMed/NCBI

22 

Verschraegen CF, Matei C, Loyer E, Malpica A, Tornos C, Kudelka AP and Kavanagh JJ: Octreotide induced remission of a refractory small cell carcinoma of the endometrium. Int J Gynecol Cancer. 9:80–85. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kobayashi A, Yahata T, Nanjo S, Mizoguchi M, Yamamoto M, Mabuchi Y, Yagi S, Minami S and Ino K: Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature. Mol Clin Oncol 6: 881-885, 2017.
APA
Kobayashi, A., Yahata, T., Nanjo, S., Mizoguchi, M., Yamamoto, M., Mabuchi, Y. ... Ino, K. (2017). Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature. Molecular and Clinical Oncology, 6, 881-885. https://doi.org/10.3892/mco.2017.1229
MLA
Kobayashi, A., Yahata, T., Nanjo, S., Mizoguchi, M., Yamamoto, M., Mabuchi, Y., Yagi, S., Minami, S., Ino, K."Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature". Molecular and Clinical Oncology 6.6 (2017): 881-885.
Chicago
Kobayashi, A., Yahata, T., Nanjo, S., Mizoguchi, M., Yamamoto, M., Mabuchi, Y., Yagi, S., Minami, S., Ino, K."Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature". Molecular and Clinical Oncology 6, no. 6 (2017): 881-885. https://doi.org/10.3892/mco.2017.1229
Copy and paste a formatted citation
x
Spandidos Publications style
Kobayashi A, Yahata T, Nanjo S, Mizoguchi M, Yamamoto M, Mabuchi Y, Yagi S, Minami S and Ino K: Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature. Mol Clin Oncol 6: 881-885, 2017.
APA
Kobayashi, A., Yahata, T., Nanjo, S., Mizoguchi, M., Yamamoto, M., Mabuchi, Y. ... Ino, K. (2017). Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature. Molecular and Clinical Oncology, 6, 881-885. https://doi.org/10.3892/mco.2017.1229
MLA
Kobayashi, A., Yahata, T., Nanjo, S., Mizoguchi, M., Yamamoto, M., Mabuchi, Y., Yagi, S., Minami, S., Ino, K."Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature". Molecular and Clinical Oncology 6.6 (2017): 881-885.
Chicago
Kobayashi, A., Yahata, T., Nanjo, S., Mizoguchi, M., Yamamoto, M., Mabuchi, Y., Yagi, S., Minami, S., Ino, K."Rapidly progressing large-cell neuroendocrine carcinoma arising from the uterine corpus: A case report and review of the literature". Molecular and Clinical Oncology 6, no. 6 (2017): 881-885. https://doi.org/10.3892/mco.2017.1229
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