Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
June-2017 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2017 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Double‑blind randomized study of oral glutamine on the management of radio/chemotherapy‑induced mucositis and dermatitis in head and neck cancer

  • Authors:
    • David Lopez‑Vaquero
    • Lucia Gutierrez‑Bayard
    • Juan‑Andres Rodriguez‑Ruiz
    • Monica Saldaña‑Valderas
    • Pedro Infante‑Cossio
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Donostia University Hospital, 20014 San Sebastian, Spain, Department of Radiation Oncology, Puerta del Mar University Hospital, 11009 Cadiz, Spain, Department of Oral and Maxillofacial Surgery, Puerta del Mar University Hospital, 11009 Cadiz, Spain, Department of Clinical Pharmacology, Puerta del Mar University Hospital, 11009 Cadiz, Spain, Department of Surgery, School of Medicine, University of Seville, 41009 Seville, Spain
  • Pages: 931-936
    |
    Published online on: May 5, 2017
       https://doi.org/10.3892/mco.2017.1238
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

This randomized clinical trial was designed to determine whether glutamine administration was effective in reducing the incidence and severity of mucositis and dermatitis induced by radiotherapy (RT) or chemoradiotherapy (CHRT) in patients with head and neck cancer (HNC). Fifty patients were randomized to receive orally either L‑Glutamine or placebo (25 patients in each arm). In the glutamine‑treated group, 10 g of oral glutamine was administered three times daily. The primary endpoint was to compare the appearance of clinical mucositis between groups at the 6th week, according to the Common Terminology Criteria for Adverse Events. Secondary endpoints were: Functional mucositis, mucositis onset, cervicofacial dermatitis, pain, weight loss and assessment of quality of life (according to the M.D. Anderson Symptom Inventory‑Head and Neck). In total, 76 and 87.5% developed clinical mucositis in the glutamine and placebo group, respectively. The incidence and severity grade of mucositis at the 6th week did not exhibit statistically significantly differences between the two groups, although it had a higher value in the placebo group. Significant reduction of dermatitis incidence (P=0.038) and severity (P=0.032) was found in the glutamine group. There were no differences in other outcomes such as pain, weight loss and mucositis onset, in treatment parameters including concomitant chemotherapy, radiation dose and previous surgery, or in quality of life. The present study revealed that glutamine provided slight clinical effects compared with placebo in terms of reducing oral mucositis induced by RT or CHRT in patients with HNC at the 6th week; however, the results were not statistically significant. Although the findings suggested a significant benefit in reducing the incidence and severity of dermatitis, further confirmatory studies are required.
View Figures

Figure 1

View References

1 

Moslemi D, Nokhandani AM, Otaghsaraei MT, Moghadamnia Y, Kazemi S and Moghadamnia AA: Management of chemo/radiation-induced oral mucositis in patients with head and neck cancer: A review of the current literature. Radiother Oncol. 120:13–20. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, Nalysnyk L and Zilberberg MD: Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review. Radiother Oncol. 66:253–262. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Harada K, Ferdous T, Horinaga D, Uchida K, Mano T, Mishima K, Park S, Hanazawa H, Takahashi S, Okita A, et al: Efficacy of elemental diet on prevention for chemoradiotherapy-induced oral mucositis in patients with oral squamous cell carcinoma. Support Care Cancer. 24:953–959. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, et al: Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 350:1937–1944. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Elliott EA, Wright JR, Swann RS, Nguyen-Tân F, Takita C, Bucci MK, Garden AS, Kim H, Hug EB, Ryu J, et al: Phase III trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: Results of radiation therapy oncology group trial 99–13. J Clin Oncol. 24:2092–2097. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Giro C, Berger B, Bölke E, Ciernik IF, Duprez F, Locati L, Maillard S, Ozsahin M, Pfeffer R, Robertson AG, et al: High rate of severe radiation dermatitis during radiation therapy with concurrent cetuximab in head and neck cancer: Results of a survey in EORTC institutes. Radiother Oncol. 90:166–171. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Mead GM: Management of oral mucositis associated with cancer chemotherapy. Lancet. 359:815–816. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Vélez I, Tamara LA and Mintz S: Management of oral mucositis induced by chemotherapy and radiotherapy: An update. Quintessence Int. 35:129–136. 2004.PubMed/NCBI

9 

Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire DB, Migliorati C, Nicolatou-Galitis O, Peterson DE, et al: MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 120:1453–1461. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Stokman MA, Spijkervet FK, Boezen HM, Schouten JP, Roodenburg JL and de Vries EG: Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: Results of meta-analyses. J Dent Res. 85:690–700. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber-Durlacher JE, Migliorati CA, McGuire DB, Hutchins RD and Peterson DE: Mucositis Study Section of the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology: Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer. 109:820–831. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Henke M, Alfonsi M, Foa P, Giralt J, Bardet E, Cerezo L, Salzwimmer M, Lizambri R, Emmerson L, Chen MG and Berger D: Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: A randomized, placebo-controlled trial. J Clin Oncol. 29:2815–2820. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Xu JL, Xia R, Sun ZH, Sun L, Min X, Liu C, Zhang H and Zhu YM: Effects of honey use on the management of radio/chemotherapy-induced mucositis: A meta-analysis of randomized controlled trials. Int J Oral Maxillofac Surg. 45:1618–1625. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Wischmeyer PE: Clinical applications of L-glutamine: Past, present, and future. Nutr Clin Pract. 18:377–385. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Neu J, DeMarco V and Li N: Glutamine: Clinical applications and mechanisms of action. Curr Opin Clin Nutr Metab Care. 5:69–75. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Skubitz KM and Anderson PM: Oral glutamine to prevent chemotherapy induced stomatitis: A pilot study. J Lab Clin Med. 127:223–228. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Silverman S Jr: Diagnosis and management of oral mucositis. J Support Oncol. 5 2 Suppl 1:S13–S21. 2007.

18 

Savarese DM, Savy G, Vahdat L, Wischmeyer PE and Corey B: Prevention of chemotherapy and radiation toxicity with glutamine. Cancer Treat Rev. 29:501–513. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Choi K, Lee SS, Oh SJ, Lim SY, Lim SY, Jeon WK, Oh TY and Kim JW: The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test. Clin Nutr. 26:57–62. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Leung HW and Chan AL: Glutamine in alleviation of radiation-induced severe oral mucositis: A meta-analysis. Nutr Cancer. 68:734–742. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Huang EY, Leung SW, Wang CJ, Chen HC, Sun LM, Fang FM, Yeh SA, Hsu HC and Hsiung CY: Oral glutamine to alleviate radiation-induced oral mucositis: A pilot randomized trial. Int J Radiat Oncol Biol Phys. 46:535–539. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Cerchietti LC, Navigante AH, Lutteral MA, Castro MA, Kirchuk R, Bonomi M, Cabalar ME, Roth B, Negretti G, Sheinker B and Uchima P: Double-blinded, placebo-controlled trial on intravenous L-alanyl-L-glutamine in the incidence of oral mucositis following chemoradiotherapy in patients with head and-neck cancer. Int J Radiat Oncol Biol Phys. 65:1330–1337. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Chattopadhyay S, Saha A, Azam M, Mukherjee A and Sur PK: Role of oral glutamine in alleviation and prevention of radiation-induced oral mucositis: A prospective randomized study. South Asian J Cancer. 3:8–12. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Tsujimoto T, Yamamoto Y, Wasa M, Takenaka Y, Nakahara S, Takagi T, Tsugane M, Hayashi N, Maeda K, Inohara H, et al: L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial. Oncol Rep. 33:33–39. 2015.PubMed/NCBI

25 

Vidal-Casariego A, Calleja-Fernández A, Ballesteros-Pomar MD and Cano-Rodríguez I: Efficacy of glutamine in the prevention of oral mucositis and acute radiation induced esophagitis: A retrospective study. Nutr Cancer. 65:424–429. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Yarom N, Ariyawardana A, Hovan A, Barasch A, Jarvis V, Jensen SB, Zadik Y, Elad S, Bowen J and Lalla RV: Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO): Systematic review of natural agents for the management of oral mucositis in cancer patients. Support Care Cancer. 21:3209–3221. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Jebb SA, Osborne RJ, Maughan TS, Mohideen N, Mack P, Mort D, Shelley MD and Elia M: 5-fluorouracil and folinic acid induced mucositis: No effect of oral glutamine supplementation. Br J Cancer. 70:732–735. 1994. View Article : Google Scholar : PubMed/NCBI

28 

Anderson PM, Schroeder G and Skubitz KM: Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer. 83:1433–1439. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Okuno SH, Woodhouse CO, Loprinzi CL, Sloan JA, LaVasseur BI, Clemens-Schutjer D, Swan D, Axvig C, Ebbert LP, Tirona MR, et al: Phase III controlled evaluation of glutamine for decreasing stomatitis in patients receiving fluorouracil (5-FU)-based chemotherapy. Am J Clin Oncol. 22:258–261. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Ward E, Smith M, Henderson M, Reid U, Lewis I, Kinsey S, Allgar V, Bowers D and Picton SV: The effect of high-dose enteral glutamine on the incidence and severity of mucositis in paediatric oncology patients. Eur J Clin Nutr. 63:134–140. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Rubio IT, Cao Y, Hutchins LF, Westbrook KC and Klimberg VS: Effect of glutamine on methotrexate efficacy and toxicity. Ann Surg. 227:772–778; 778–780. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Cockerham MB, Weinberger BB and Lerchie SB: Oral glutamine for the prevention of oral mucositis associated with high-dose paclitaxel and melphalan for autologous bone marrow transplantation. Ann Pharmacother. 34:300–303. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Peterson DE, Jones JB and Petit RG II: Randomized, placebo-controlled trial of Saforis for prevention and treatment of oral mucositis in breast cancer patients receiving anthracycline-based chemotherapy. Cancer. 109:322–331. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Imai T, Matsuura K, Asada Y, Sagai S, Katagiri K, Ishida E, Saito D, Sadayasu R, Wada H and Saijo S: Effect of HMB/Arg/Gln on the prevention of radiation dermatitis in head and neck cancer patients treated with concurrent chemoradiotherapy. Jpn J Clin Oncol. 44:422–427. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lopez‑Vaquero D, Gutierrez‑Bayard L, Rodriguez‑Ruiz JA, Saldaña‑Valderas M and Infante‑Cossio P: Double‑blind randomized study of oral glutamine on the management of radio/chemotherapy‑induced mucositis and dermatitis in head and neck cancer. Mol Clin Oncol 6: 931-936, 2017.
APA
Lopez‑Vaquero, D., Gutierrez‑Bayard, L., Rodriguez‑Ruiz, J., Saldaña‑Valderas, M., & Infante‑Cossio, P. (2017). Double‑blind randomized study of oral glutamine on the management of radio/chemotherapy‑induced mucositis and dermatitis in head and neck cancer. Molecular and Clinical Oncology, 6, 931-936. https://doi.org/10.3892/mco.2017.1238
MLA
Lopez‑Vaquero, D., Gutierrez‑Bayard, L., Rodriguez‑Ruiz, J., Saldaña‑Valderas, M., Infante‑Cossio, P."Double‑blind randomized study of oral glutamine on the management of radio/chemotherapy‑induced mucositis and dermatitis in head and neck cancer". Molecular and Clinical Oncology 6.6 (2017): 931-936.
Chicago
Lopez‑Vaquero, D., Gutierrez‑Bayard, L., Rodriguez‑Ruiz, J., Saldaña‑Valderas, M., Infante‑Cossio, P."Double‑blind randomized study of oral glutamine on the management of radio/chemotherapy‑induced mucositis and dermatitis in head and neck cancer". Molecular and Clinical Oncology 6, no. 6 (2017): 931-936. https://doi.org/10.3892/mco.2017.1238
Copy and paste a formatted citation
x
Spandidos Publications style
Lopez‑Vaquero D, Gutierrez‑Bayard L, Rodriguez‑Ruiz JA, Saldaña‑Valderas M and Infante‑Cossio P: Double‑blind randomized study of oral glutamine on the management of radio/chemotherapy‑induced mucositis and dermatitis in head and neck cancer. Mol Clin Oncol 6: 931-936, 2017.
APA
Lopez‑Vaquero, D., Gutierrez‑Bayard, L., Rodriguez‑Ruiz, J., Saldaña‑Valderas, M., & Infante‑Cossio, P. (2017). Double‑blind randomized study of oral glutamine on the management of radio/chemotherapy‑induced mucositis and dermatitis in head and neck cancer. Molecular and Clinical Oncology, 6, 931-936. https://doi.org/10.3892/mco.2017.1238
MLA
Lopez‑Vaquero, D., Gutierrez‑Bayard, L., Rodriguez‑Ruiz, J., Saldaña‑Valderas, M., Infante‑Cossio, P."Double‑blind randomized study of oral glutamine on the management of radio/chemotherapy‑induced mucositis and dermatitis in head and neck cancer". Molecular and Clinical Oncology 6.6 (2017): 931-936.
Chicago
Lopez‑Vaquero, D., Gutierrez‑Bayard, L., Rodriguez‑Ruiz, J., Saldaña‑Valderas, M., Infante‑Cossio, P."Double‑blind randomized study of oral glutamine on the management of radio/chemotherapy‑induced mucositis and dermatitis in head and neck cancer". Molecular and Clinical Oncology 6, no. 6 (2017): 931-936. https://doi.org/10.3892/mco.2017.1238
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team