Clinical outcome of patients treated with re-irradiation for spine or pelvic bone metastasis: A multi-institutional analysis of 98 patients

Suzuki,Gen; Yamazaki,Hideya; Aibe,Norihiro; Masui,Koji; Kimoto,Takuya; Tatekawa,Kotoha; Nakashima,Akinori; Takenaka,Tadashi; Nishimura,Takeshi; Sasaki,Naomi; Oh,Ryoong-Jin; Konishi,Koji; Okabe,Haruumi; Nagasawa,Shinsuke; Yamada,Kei

doi:10.3892/mco.2017.1245

June-2017 Volume 6 Issue 6

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June-2017 Volume 6 Issue 6

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Article Open Access

Clinical outcome of patients treated with re-irradiation for spine or pelvic bone metastasis: A multi-institutional analysis of 98 patients

Authors:
- Gen Suzuki
- Hideya Yamazaki
- Norihiro Aibe
- Koji Masui
- Takuya Kimoto
- Kotoha Tatekawa
- Akinori Nakashima
- Tadashi Takenaka
- Takeshi Nishimura
- Naomi Sasaki
- Ryoong-Jin Oh
- Koji Konishi
- Haruumi Okabe
- Shinsuke Nagasawa
- Kei Yamada
View Affiliations / Copyright

Affiliations: Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602‑8566, Japan, Department of Radiology, Miyakojima iGRT Clinic, Osaka 534-0021, Japan, Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-0025, Japan, Department of Radiology, Uji Takeda Hospital, Uji 611-0021, Japan, Department of Radiology, Saiseikai Shigaken Hospital, Ritto 520-3240, Japan

Copyright: © Suzuki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 871-875
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Published online on: May 8, 2017

https://doi.org/10.3892/mco.2017.1245
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Abstract

The present study aimed to describe the clinical results of re-irradiation (Re-RT) for spine or pelvic bone metastasis at the same initial irradiated area. Between April 2010 and March 2014, cases involving 98 patients with spine or pelvic bone metastasis who had undergone Re-RT at five institutions were reviewed. The clinical outcomes following Re-RT were evaluated, including overall survival (OS) and severe adverse events. The median time interval from initial radiation therapy (RT) to Re-RT was 439 days (range, 23-4,993 days), and the median duration of patient follow-up was 256 days (range, 11-2,284 days). The median biological effective dose for the Re-RT was 150 Gy2 (range, 17-240 Gy2; α/β = 2). Severe late adverse events occurred in two patients who underwent three-dimensional conformal radiotherapy for lumbar spine or pelvic bone metastases, which may be associated with tumor progression. The median survival time following Re-RT was 255 days, and the actuarial OS rate at 1 year was 36%. The interval between initial RT and Re-RT, and their performance statuses (PS) were significant independent prognostic factors for OS rates in multivariate analysis. Re-RT for spine or pelvic bone metastases is a relatively acceptable option with low risk of anticipated severe adverse events, particularly for patients with good PS following a long disease-free interval.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical outcome of patients treated with re-irradiation for spine or pelvic bone metastasis: A multi-institutional analysis of 98 patients

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