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Case Report

Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report

  • Authors:
    • Katherina Bernadette Sreter
    • Blazenka Barisic
    • Marija Barisic Kutija
    • Suzana Kukulj
    • Miroslav Samarzija
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Immunology, Pulmonology and Rheumatology, University Hospital Centre ‘Sestre Milosrdnice’, 10000 Zagreb, Croatia, Department of Allergy and Chronic Obstructive Pulmonary Disease, Clinic for Respiratory Diseases ‘Jordanovac’, University Hospital Centre Zagreb, 10000 Zagreb, Croatia, Department of Ophthalmology, University Hospital Centre Zagreb, 10000 Zagreb, Croatia, Department of Mediastinal Tumours, Clinic for Respiratory Diseases ‘Jordanovac’, University Hospital Centre Zagreb, 10000 Zagreb, Croatia, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
  • Pages: 921-924
    |
    Published online on: May 8, 2017
       https://doi.org/10.3892/mco.2017.1248
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Abstract

Adie's syndrome (AS) and paraneoplastic sensorimotor neuropathy with cerebellar ataxia (PSN CA) are extremely rare, rapidly progressive, autoimmune diseases associated with the development of antibodies against neuronal‑specific Hu proteins that are abnormally expressed in small‑cell lung cancer (SCLC). We herein present the unique case of a 55‑year‑old obese woman, previous heavy smoker, who, during treatment with standard cisplatin‑etoposide chemotherapy for limited‑stage SCLC, developed simultaneous AS and worsening symptoms consistent with PSN CA that led to significant neurological disability and severe axonal electrophysiological pattern on nerve conduction studies. Serology confirmed the presence of low‑titre type 1 antineuronal nuclear antibodies (ANNA‑1), previously referred to as anti‑Hu antibodies. Following plasmapheresis, immunosuppressive therapy and physical rehabilitation, the neurological symptoms progressively improved. The tumour completely regressed, with no recurrence detected on subsequent radiological examinations. The aim of this case was to highlight the importance of a multidisciplinary team approach for early recognition and rapid treatment of paraneoplastic neurological syndromes (PNS) as key to achieving significant recovery and marked improvement of the neurological deficit. This report extends the literature by confirming earlier studies showing that the presence of serum ANNA‑1 in SCLC, an aggressive type of pulmonary carcinoma that is challenging to treat, may portend a more favourable prognosis and response to chemotherapy. Thus, patients with SCLC and new‑onset neurological symptoms should be tested for ANNA‑1. The role of a multimodality approach to treating PNS is also emphasized.
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Copy and paste a formatted citation
Spandidos Publications style
Sreter KB, Barisic B, Barisic Kutija M, Kukulj S and Samarzija M: Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report. Mol Clin Oncol 6: 921-924, 2017.
APA
Sreter, K.B., Barisic, B., Barisic Kutija, M., Kukulj, S., & Samarzija, M. (2017). Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report. Molecular and Clinical Oncology, 6, 921-924. https://doi.org/10.3892/mco.2017.1248
MLA
Sreter, K. B., Barisic, B., Barisic Kutija, M., Kukulj, S., Samarzija, M."Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report". Molecular and Clinical Oncology 6.6 (2017): 921-924.
Chicago
Sreter, K. B., Barisic, B., Barisic Kutija, M., Kukulj, S., Samarzija, M."Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report". Molecular and Clinical Oncology 6, no. 6 (2017): 921-924. https://doi.org/10.3892/mco.2017.1248
Copy and paste a formatted citation
x
Spandidos Publications style
Sreter KB, Barisic B, Barisic Kutija M, Kukulj S and Samarzija M: Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report. Mol Clin Oncol 6: 921-924, 2017.
APA
Sreter, K.B., Barisic, B., Barisic Kutija, M., Kukulj, S., & Samarzija, M. (2017). Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report. Molecular and Clinical Oncology, 6, 921-924. https://doi.org/10.3892/mco.2017.1248
MLA
Sreter, K. B., Barisic, B., Barisic Kutija, M., Kukulj, S., Samarzija, M."Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report". Molecular and Clinical Oncology 6.6 (2017): 921-924.
Chicago
Sreter, K. B., Barisic, B., Barisic Kutija, M., Kukulj, S., Samarzija, M."Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report". Molecular and Clinical Oncology 6, no. 6 (2017): 921-924. https://doi.org/10.3892/mco.2017.1248
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