Radiation-associated colon cancer: A case report

Sasaki,Kazuhito; Ishihara,Soichiro; Hata,Keisuke; Kiyomatsu,Tomomichi; Nozawa,Hiroaki; Kawai,Kazushige; Tanaka,Toshiaki; Nishikawa,Takeshi; Otani,Kensuke; Yasuda,Koji; Kaneko,Manabu; Murono,Koji; Abe,Hiroyuki; Morikawa,Teppei; Watanabe,Toshiaki

doi:10.3892/mco.2017.1252

June-2017 Volume 6 Issue 6

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June-2017 Volume 6 Issue 6

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Case Report Open Access

Radiation-associated colon cancer: A case report

Authors:
- Kazuhito Sasaki
- Soichiro Ishihara
- Keisuke Hata
- Tomomichi Kiyomatsu
- Hiroaki Nozawa
- Kazushige Kawai
- Toshiaki Tanaka
- Takeshi Nishikawa
- Kensuke Otani
- Koji Yasuda
- Manabu Kaneko
- Koji Murono
- Hiroyuki Abe
- Teppei Morikawa
- Toshiaki Watanabe
View Affiliations / Copyright

Affiliations: Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo 113‑8655, Japan, Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113‑8655, Japan

Copyright: © Sasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 817-820
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Published online on: May 8, 2017

https://doi.org/10.3892/mco.2017.1252
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Abstract

Radiation-associated colon cancer is a rare clinical entity. We herein describe the case of a patient with radiation-associated colon cancer who had undergone low anterior resection for rectal cancer following preoperative radiotherapy. Certain characteristics of radiation‑associated colon cancer are highlighted. The patient was a 48‑year‑old man who had undergone low anterior resection for rectal cancer following preoperative radiotherapy at a total dose of 50 Gy, at the age of 29 years. When the patient presented at the University of Tokyo Hospital, 19 years after the surgery, he complained of severe anal pain and frequent defecation. Colonoscopy revealed two flat tumors in the sigmoid colon, located 10 cm to the oral side of the anastomosis site, which were diagnosed as well‑differentiated adenocarcinomas. In addition, colonoscopy identified five flat polyps near the tumors, which were resected endoscopically. Computed tomography and magnetic resonance imaging revealed a mass in the sigmoid colon and no evidence of distant metastasis. Laparoscopic‑assisted intersphincteric resection of the rectum and sigmoid colon with diverting ileostomy was performed. There were no specific postoperative complications and the patient was discharged from the hospital on the 20th postoperative day. On pathological examination, the resected rectum and sigmoid colon contained two separate tumors and six flat polyps. The two tumors were diagnosed as well‑differentiated adenocarcinomas with invasion of the subserosa and submucosa, respectively. A total of 17 regional lymph nodes without metastasis were resected. The six flat polyps were diagnosed as tubular adenomas. We herein present a case of a radiation‑associated colon cancer in a patient who had undergone low anterior resection for rectal cancer following preoperative radiotherapy 19 years prior. Colonoscopic surveillance of radiation‑associated colon cancer may be indicated for rectal cancer patients treated with preoperative radiotherapy, particularly for those with long‑standing radiation‑induced colitis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Radiation-associated colon cancer: A case report

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