Diffuse fluorodeoxyglucose‑positron uptake in the bone marrow of a patient with granulocyte colony‑stimulating factor‑producing pleomorphic carcinoma of the lung: A case report

Makino,Takashi; Hata,Yoshinobu; Otsuka,Hajime; Koezuka,Satoshi; Kikuchi,Nao; Isobe,Kazutoshi; Tochigi,Naobumi; Shibuya,Kazutoshi; Homma,Sakae; Iyoda,Akira

doi:10.3892/mco.2017.1271

July-2017 Volume 7 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

July-2017 Volume 7 Issue 1

Full Size Image

Case Report

Diffuse fluorodeoxyglucose‑positron uptake in the bone marrow of a patient with granulocyte colony‑stimulating factor‑producing pleomorphic carcinoma of the lung: A case report

Authors:
- Takashi Makino
- Yoshinobu Hata
- Hajime Otsuka
- Satoshi Koezuka
- Nao Kikuchi
- Kazutoshi Isobe
- Naobumi Tochigi
- Kazutoshi Shibuya
- Sakae Homma
- Akira Iyoda
View Affiliations / Copyright

Affiliations: Division of Chest Surgery, Toho University School of Medicine, Tokyo 143‑8541, Japan, Division of Respiratory Medicine, Toho University School of Medicine, Tokyo 143‑8541, Japan, Department of Surgical Pathology, Toho University School of Medicine, Tokyo 143‑8541, Japan
Pages: 103-106
|
Published online on: May 29, 2017

https://doi.org/10.3892/mco.2017.1271
Expand metrics +

Abstract

The current study presents the case of a 66‑year‑old male presenting with fever and chest pain. Chest enhanced computed tomography scanning revealed a mass shadow in the right upper lobe with chest wall invasion. 18‑Fluorodeoxyglucose‑positron emission tomography (FDG‑PET) identified the localized uptake of the mass lesion in the right upper lobe, in addition to diffuse uptake by the bone marrow. The laboratory data on admission revealed marked leukocytosis and an elevated C‑reactive protein level (CRP). Serum concentrations of granulocyte colony‑stimulating factor (G‑CSF) and interleukin 6 were increased. Based on a clinical diagnosis of non‑small cell lung cancer (c‑T3N0M0 stage IIB), the patient underwent right upper lobectomy with chest wall resection. The histological examination showed a pulmonary pleomorphic carcinoma. Immunohistochemical analysis of the resected tumor tissues revealed positive staining for G‑CSF. The patient's high‑grade fever, leukocytosis, and elevated CRP level rapidly subsided following the resection. This confirmed that the tumor was a G‑CSF‑producing pulmonary pleomorphic carcinoma. Five months after the resection, the diffuse FDG uptake in the bone marrow was absent, even with the presence of a small pulmonary metastasis and marginal serum G‑CSF elevation. Diffuse FDG uptake in bone marrow induced by G‑CSF producing pleomorphic carcinoma must be taken into consideration, in order for it not to be misinterpreted as diffuse bone marrow metastases or hematologic malignancy.

View Figures

View References

1	Sekido Y, Sato M, Usami N, Shigemitsu K, Mori S, Maeda O, Yokoi T, Hasegawa Y, Yoshioka H and Shimokata K: Establishment of a large cell lung cancer cell line (Y-ML-1B) producing granulocyte colony-stimulating factor. Cancer Genet Cytogenet. 137:33–42. 2002. View Article : Google Scholar : PubMed/NCBI
2	Inoue M, Minami M, Fujii Y, Matsuda H, Shirakura R and Kido T: Granulocyte colony-stimulating factor and interleukin-6-producing lung cancer cell line, LCAM. J Surg Oncol. 64:347–350. 1997. View Article : Google Scholar : PubMed/NCBI
3	Katsumata N, Eguchi K, Fukuda M, Yamamoto N, Ohe Y, Oshita F, Tamura T, Shinkai T and Saijo N: Serum levels of cytokines in patients with untreated primary lung cancer. Clin Cancer Res. 2:553–559. 1996.PubMed/NCBI
4	Tsuyuoka R, Takahashi T, Sasaki Y, Taniguchi Y, Fukumoto M, Suzuki A, Nakamura K, Kobayashi S, Kudo T and Nakao K: Colony-stimulating factor-producing tumours: Production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production. Eur J Cancer. 30A:2130–2136. 1994. View Article : Google Scholar : PubMed/NCBI
5	Kimura H, Yamaguchi Y, Sun L, Iwagami S and Sugita K: Establishment of large cell lung cancer cell lines secreting hematopoietic factors inducing leukocytosis and thrombocytosis. Jpn J Clin Oncol. 22:313–319. 1992.PubMed/NCBI
6	Matsuguchi T, Okamura S, Kawasaki C, Shimoda K, Omori F, Hayashi S, Kimura N and Niho Y: Constitutive production of granulocyte colony-stimulating factor and interleukin-6 by a human lung cancer cell line, KSNY: Gene amplification and increased mRNA stability. Eur J Haematol. 47:128–133. 1991. View Article : Google Scholar : PubMed/NCBI
7	Suzuki A, Takahashi T, Okuno Y, Nakamura K, Tashiro H, Fukumoto M, Konaka Y and Imura H: Analysis of abnormal expression of g-csf gene in a novel tumor cell line (KHC 287) elaborating G-CSF, IL-1 and IL-6 with co-amplification of c-myc and c-ki-ras. Int J Cancer. 48:428–433. 1991. View Article : Google Scholar : PubMed/NCBI
8	Yendamuri S, Caty L, Pine M, Adem S, Bogner P, Miller A, Demmy TL, Groman A and Reid M: Outcomes of sarcomatoid carcinoma of the lung: A Surveillance, Epidemiology, and End Results Database analysis. Surgery. 152:397–402. 2012. View Article : Google Scholar : PubMed/NCBI
9	Sugawara Y, Fisher SJ, Zasadny KR, Kison PV, Baker LH and Wahl RL: Preclinical and clinical studies of bone marrow uptake of fluorine-1-fluorodeoxyglucose with or without granulocyte colony-stimulating factor during chemotherapy. J Clin Oncol. 16:173–180. 1998. View Article : Google Scholar : PubMed/NCBI
10	Kazama T, Swanston N, Podoloff DA and Macapinlac HA: Effect of colony-stimulating factor and conventional- or high-dose chemotherapy on FDG uptake in bone marrow. Eur J Nucl Med Mol Imaging. 32:1406–1411. 2005. View Article : Google Scholar : PubMed/NCBI
11	Brambilla E, Travis WD, Colby TV, Corrin B and Shimosato Y: The new World Health Organization classification of lung tumours. Eur Respir J. 18:1059–1068. 2001. View Article : Google Scholar : PubMed/NCBI
12	Ito K, Oizumi S, Fukumoto S, Harada M, Ishida T, Fujita Y, Harada T, Kojima T, Yokouchi H and Nishimura M; Hokkaido Lung Cancer Clinical Study Group, : Clinical characteristics of pleomorphic carcinoma of the lung. Lung Cancer. 68:204–210. 2010. View Article : Google Scholar : PubMed/NCBI
13	Fukuyama T, Ichiki Y, Yamada S, Shigematsu Y, Baba T, Nagata Y, Mizukami M, Sugaya M, Takenoyama M, Hanagiri T, et al: Cytokine production of lung cancer cell lines: Correlation between their production and the inflammatory/immunological responses both in vivo and in vitro. Cancer Sci. 98:1048–1054. 2007. View Article : Google Scholar : PubMed/NCBI
14	Guo Y, Xu F, Lu T, Duan Z and Zhang Z: Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev. 38:904–910. 2012. View Article : Google Scholar : PubMed/NCBI
15	Mabuchi S, Morimoto A, Fujita M, Isohashi K and Kimura T: G-CSF induces focal intense bone marrow FDG uptake mimicking multiple bone metastases from uterine cervical cancer: A case report and review of the literature. Eur J Gynaecol Oncol. 33:316–317. 2012.PubMed/NCBI
16	Asano S, Urabe A, Okabe T, Sato N and Kondo Y: Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood. 49:845–852. 1977.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Diffuse fluorodeoxyglucose‑positron uptake in the bone marrow of a patient with granulocyte colony‑stimulating factor‑producing pleomorphic carcinoma of the lung: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles