Asbestos-related lung cancers: A retrospective clinical and pathological study

Uguen,Marie; Dewitte,Jean‑Dominique; Marcorelles,Pascale; Loddé,Brice; Pougnet,Richard; Saliou,Philippe; De Braekeleer,Marc; Uguen,Arnaud

doi:10.3892/mco.2017.1277

July-2017 Volume 7 Issue 1

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July-2017 Volume 7 Issue 1

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Article

Asbestos-related lung cancers: A retrospective clinical and pathological study

Authors:
- Marie Uguen
- Jean‑Dominique Dewitte
- Pascale Marcorelles
- Brice Loddé
- Richard Pougnet
- Philippe Saliou
- Marc De Braekeleer
- Arnaud Uguen
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Affiliations: Department of Occupational and Environmental Diseases, Brest University Hospital, University of Brest, F‑29220 Brest, France, Department of Pathology, Brest University Hospital, University of Brest, F‑29220 Brest, France, Department of Public Health, Brest University Hospital, University of Brest, F‑29220 Brest, France, Laboratory of Neurosciences of Brest (EA4685), Faculty of Medicine, The University of Western Brittany, F‑29220 Brest, France
Pages: 135-139
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Published online on: May 30, 2017

https://doi.org/10.3892/mco.2017.1277
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Abstract

Exposure to asbestos results in serious risks of developing mesothelioma and lung cancer. The link between asbestos exposure and lung carcinoma is well established. Nevertheless, precise histopathological data are poorly considered when investigating the asbestos‑cancer link in a compensatory approach. In the present study, we aim to describe the features of individuals with compensated lung cancer who were referred to an occupational disease center, regarding occupational exposure to asbestos, smoking history and pathological data. We led a retrospective study of compensated ARLC cases seen in our occupational disease center between 2003 and 2013. A total of 146 men were included (mean age at diagnosis, 63.2 years) of whom approximately 90% were heavy current or former smokers (mean value, 30.4 packs/year). The major industries associated with the lung cancer cases were shipbuilding (69.9%), and building construction (7.5%) in this harbor region. The results of the present study showed that lung upper lobe was most prevalent (61.6%) and an excess of adenocarcinoma was found (45.9%), followed by squamous cell carcinoma (38.4%) as well as thoracic sarcomas (2.1%). Neoplasm was not histologically proven in 6.8% of the cases. Subsequent pathology examinations also reclassified 2 tumors as metastases from esophageal and laryngeal origins. In conclusion, smoking prevention should be encouraged in asbestos‑exposed workers as reflected by the number of smokers with asbestos‑related lung cancer. Thus, histological data should be considered further to evaluate the potent relationship between asbestos exposure and lung malignancy, especially in a compensatory approach.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Asbestos-related lung cancers: A retrospective clinical and pathological study

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