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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Case Report

68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review

  • Authors:
    • Lars J. Petersen
    • Julie B. Nielsen
    • Katja Dettmann
    • Rune V. Fisker
    • Uwe Haberkorn
    • Louise Stenholt
    • Helle D. Zacho
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Clinical Cancer Research Center, Aalborg University Hospital, DK‑9000 Aalborg, Denmark, Department of Urology, Regional Hospital West Jutland, DK‑7500 Holstebro, Denmark, Department of Nuclear Medicine, University Hospital of Heidelberg, D‑69120 Heidelberg, Germany, The Medical Library, Aalborg University Hospital, DK‑9000 Aalborg, Denmark
  • Pages: 67-72
    |
    Published online on: May 31, 2017
       https://doi.org/10.3892/mco.2017.1280
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Abstract

Localization of prostate cancer recurrence, particularly in the bones, is a major challenge with standard of care imaging in patients with biochemical recurrence following curatively intended treatment. Gallium‑68‑labeled prostate specific membrane antigen positron emission tomography/computed tomography (68Ga‑PSMA PET/CT) is a novel and promising method for imaging in prostate cancer. The present study reports two cases of patients with prostate cancer with biochemical recurrence, with evidence of bone metastases on 68Ga‑PSMA PET/CT images and low prostate specific antigen PSA levels (<2 ng/ml) and PSA doubling time >6 months. The bone metastases were verified by supplementary imaging with 18F‑sodium fluoride PET/CT and magnetic resonance imaging as well as biochemical responses to androgen deprivation therapy. Therefore, 68Ga‑PSMA PET/CT is promising for the restaging of patients with prostate cancer with biochemical recurrence, including patients with low PSA levels and low PSA kinetics.
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1 

Vargas HA, Martin-Malburet AG, Takeda T, Corradi RB, Eastham J, Wibmer A, Sala E, Zelefsky MJ, Weber WA and Hricak H: Localizing sites of disease in patients with rising serum prostate-specific antigen up to 1 ng/ml following prostatectomy: How much information can conventional imaging provide? Urol Oncol. 34:482.e5–482.e10. 2016. View Article : Google Scholar

2 

Kane CJ, Amling CL, Johnstone PA, Pak N, Lance RS, Thrasher JB, Foley JP, Riffenburgh RH and Moul JW: Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy. Urology. 61:607–611. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Stephenson AJ, Scardino PT, Kattan MW, Pisansky TM, Slawin KM, Klein EA, Anscher MS, Michalski JM, Sandler HM, Lin DW, et al: Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy. J Clin Oncol. 25:2035–2041. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Stish BJ, Pisansky TM, Harmsen WS, Davis BJ, Tzou KS, Choo R and Buskirk SJ: Improved metastasis-free and survival outcomes with early salvage radiotherapy in men with detectable prostate-specific antigen after prostatectomy for prostate cancer. J Clin Oncol. pii:JCO6834252016.(Epub ahead of print).

5 

Ceci F, Castellucci P, Graziani T, Schiavina R, Chondrogiannis S, Bonfiglioli R, Costa S, Virgolini IJ, Rubello D, Fanti S and Colletti PM: 11C-choline PET/CT identifies osteoblastic and osteolytic lesions in patients with metastatic prostate cancer. Clin Nucl Med. 40:e265–e270. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Fanti S, Minozzi S, Castellucci P, Balduzzi S, Herrmann K, Krause BJ, Oyen W and Chiti A: PET/CT with (11)C-choline for evaluation of prostate cancer patients with biochemical recurrence: Meta-analysis and critical review of available data. Eur J Nucl Med Mol Imaging. 43:55–69. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Sobol I, Zaid HB, Haloi R, Mynderse LA, Froemming AT, Lowe VJ, Davis BJ, Kwon ED and Karnes RJ: Contemporary mapping of post-prostatectomy prostate cancer relapse with c-11-choline positron emission tomography and multiparametric magnetic resonance imaging. J Urol. 197:129–134. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Kjölhede H, Ahlgren G, Almquist H, Liedberg F, Lyttkens K, Ohlsson T and Bratt O: (18)F-choline PET/CT for early detection of metastases in biochemical recurrence following radical prostatectomy. World J Urol. 33:1749–1752. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Castellucci P, Ceci F, Graziani T, Schiavina R, Brunocilla E, Mazzarotto R, Pettinato C, Celli M, Lodi F and Fanti S: Early biochemical relapse after radical prostatectomy: Which prostate cancer patients may benefit from a restaging 11C-Choline PET/CT scan before salvage radiation therapy? J Nucl Med. 55:1424–1429. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Giovacchini G, Picchio M, Briganti A, Cozzarini C, Scattoni V, Salonia A, Landoni C, Gianolli L, Di MN, Rigatti P, et al: [11C]choline positron emission tomography/computerized tomography to restage prostate cancer cases with biochemical failure after radical prostatectomy and no disease evidence on conventional imaging. J Urol. 184:938–943. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Giovacchini G, Picchio M, Garcia-Parra R, Mapelli P, Briganti A, Montorsi F, Gianolli L and Messa C: [11C]choline positron emission tomography/computerized tomography for early detection of prostate cancer recurrence in patients with low increasing prostate specific antigen. J Urol. 189:105–110. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Heidenreich A, Bastian PJ, Bellmunt J, Bolla M, Joniau S, van der Kwast T, Mason M, Matveev V, Wiegel T, Zattoni F, et al: EAU guidelines on prostate cancer Part 1 Screening, diagnosis, and local treatment with curative intent update 2013. Eur Urol. 65:124–137. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Afshar-Oromieh A, Avtzi E, Giesel FL, Holland-Letz T, Linhart HG, Eder M, Eisenhut M, Boxler S, Hadaschik BA, Kratochwil C, et al: The diagnostic value of PET/CT imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging. 42:197–209. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Eiber M, Maurer T, Souvatzoglou M, Beer AJ, Ruffani A, Haller B, Graner FP, Kübler H, Haberhorn U, Eisenhut M, et al: Evaluation of Hybrid 68Ga-PSMA Ligand PET/CT in 248 patients with biochemical recurrence after radical prostatectomy. J Nucl Med. 56:668–674. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Maurer T, Eiber M, Schwaiger M and Gschwend JE: Current use of PSMA-PET in prostate cancer management. Nat Rev Urol. 13:226–235. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Evangelista L, Briganti A, Fanti S, Joniau S, Reske S, Schiavina R, Stief C, Thalmann GN and Picchio M: New clinical indications for (18)F/(11)C-choline, new tracers for positron emission tomography and a promising hybrid device for prostate cancer staging: A systematic review of the literature. Eur Urol. 70:161–175. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Perera M, Papa N, Christidis D, Wetherell D, Hofman MS, Murphy DG, Bolton D and Lawrentschuk N: Sensitivity, specificity and predictors of positive 68Ga-prostate-specific membrane antigen positron emission tomography in advanced prostate cancer: A systematic review and meta-analysis. Eur Urol. 70:926–937. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Barentsz JO, Richenberg J, Clements R, Choyke P, Verma S, Villeirs G, Rouviere O, Logager V and Futterer JJ: European Society of Urogenital Radiology: ESUR prostate MR guidelines 2012. Eur Radiol. 22:746–757. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Passoni NM, Suardi N, Abdollah F, Picchio M, Giovacchini G, Messa C, Freschi M, Montorsi F and Briganti A: Utility of [11C]choline PET/CT in guiding lesion-targeted salvage therapies in patients with prostate cancer recurrence localized to a single lymph node at imaging: Results from a pathologically validated series. Urol Oncol. 32:38.e9–e16. 2014. View Article : Google Scholar

20 

Afshar-Oromieh A, Zechmann CM, Malcher A, Eder M, Eisenhut M, Linhart HG, Holland-Letz T, Hadaschik BA, Giesel FL, Debus J and Haberkorn U: Comparison of PET imaging with a (68)Ga-labelled PSMA ligand and (18)F-choline-based PET/CT for the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging. 41:11–20. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Bluemel C, Krebs M, Polat B, Linke F, Eiber M, Samnick S, Lapa C, Lassmann M, Riedmiller H, Czernin J, et al: 68Ga-PSMA-PET/CT in patients with biochemical prostate cancer recurrence and negative 18F-Choline-PET/CT. Clin Nucl Med. 41:515–521. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Schwenck J, Rempp H, Reischl G, Kruck S, Stenzl A, Nikolaou K, Pfannenberg C and la Fougère C: Comparison of 68Ga-labelled PSMA-11 and 11C-choline in the detection of prostate cancer metastases by PET/CT. Eur J Nucl Med Mol Imaging. 44:92–101e. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG, Moher D, Rennie D and de Vet HC; STARD Group, : Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD initiative. Fam Pract. 21:4–10. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Freitag MT, Radtke JP, Hadaschik BA, Kopp-Schneider A, Eder M, Kopka K, Haberkorn U, Roethke M, Schlemmer HP and Afshar-Oromieh A: Comparison of hybrid (68)Ga-PSMA PET/MRI and (68)Ga-PSMA PET/CT in the evaluation of lymph node and bone metastases of prostate cancer. Eur J Nucl Med Mol Imaging. 43:70–83. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Demirkol MO, Acar O, Ucar B, Ramazanoglu SR, Saglican Y and Esen T: Prostate-specific membrane antigen-based imaging in prostate cancer: impact on clinical decision making process. Prostate. 75:748–757. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Petersen LJ, Nielsen JB, Dettmann K, Fisker RV, Haberkorn U, Stenholt L and Zacho HD: 68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review. Mol Clin Oncol 7: 67-72, 2017.
APA
Petersen, L.J., Nielsen, J.B., Dettmann, K., Fisker, R.V., Haberkorn, U., Stenholt, L., & Zacho, H.D. (2017). 68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review. Molecular and Clinical Oncology, 7, 67-72. https://doi.org/10.3892/mco.2017.1280
MLA
Petersen, L. J., Nielsen, J. B., Dettmann, K., Fisker, R. V., Haberkorn, U., Stenholt, L., Zacho, H. D."68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review". Molecular and Clinical Oncology 7.1 (2017): 67-72.
Chicago
Petersen, L. J., Nielsen, J. B., Dettmann, K., Fisker, R. V., Haberkorn, U., Stenholt, L., Zacho, H. D."68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review". Molecular and Clinical Oncology 7, no. 1 (2017): 67-72. https://doi.org/10.3892/mco.2017.1280
Copy and paste a formatted citation
x
Spandidos Publications style
Petersen LJ, Nielsen JB, Dettmann K, Fisker RV, Haberkorn U, Stenholt L and Zacho HD: 68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review. Mol Clin Oncol 7: 67-72, 2017.
APA
Petersen, L.J., Nielsen, J.B., Dettmann, K., Fisker, R.V., Haberkorn, U., Stenholt, L., & Zacho, H.D. (2017). 68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review. Molecular and Clinical Oncology, 7, 67-72. https://doi.org/10.3892/mco.2017.1280
MLA
Petersen, L. J., Nielsen, J. B., Dettmann, K., Fisker, R. V., Haberkorn, U., Stenholt, L., Zacho, H. D."68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review". Molecular and Clinical Oncology 7.1 (2017): 67-72.
Chicago
Petersen, L. J., Nielsen, J. B., Dettmann, K., Fisker, R. V., Haberkorn, U., Stenholt, L., Zacho, H. D."68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review". Molecular and Clinical Oncology 7, no. 1 (2017): 67-72. https://doi.org/10.3892/mco.2017.1280
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